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Hydrogen peroxide release kinetics into saliva from different whitening products: a double-blind, randomized clinical trial

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Abstract

The objective of this study is to compare salivary hydrogen peroxide (HP) release kinetics and potential toxicity of systemic exposure of four different whitening products. A double-blind, randomized controlled trial was conducted in a Portuguese dental faculty clinic. Two hundred forty volunteers were randomized to eight intervention groups. Participants were randomly assigned to receive active or placebo applications of one of four different products: Opalescence 10% PF™ (OPL), Vivastyle® 10%™ (VS10%), Vivadent Paint On Plus™ (PO+), and Trés White Supreme™ (TWS). Saliva collection was obtained by established methods at different times. The HP salivary content was determined by a photometric method. Salivary HP variations, total amount of salivary HP, and counts of subjects above the safe daily HP dose were the main outcome measures. All whitening systems significantly released HP to the saliva when compared to placebo, and all showed different release kinetics. The adaptable tray system (TWS) presented a risk increase of 37% [20–54%, 95% confidence interval] when compared to the other systems. The use of an adaptable tray whitening system with higher concentration of HP increases the toxicity potential.

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Conflicts of interest

The authors declare that they have no conflict of interest and that the whitening systems were provided by Ultradent®, USA and Ivoclar-Vivadent®, Liechenstein.

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Authors and Affiliations

  1. Oral Biology and Biochemistry Group, Biomedical and Oral Sciences Research Unit (FCT Unit 4062), University of Lisbon School of Dental Medicine, Campus Universitário, 1649-003, Lisbon, Portugal

    Duarte Nuno da Silva Marques, António Duarte Sola Pereira da Mata, João Miguel Lourenço Silveira, Joana Rita Oliveira Faria Marques, João Pedro de Almeida Rato Amaral & Nuno Filipe Rito Parada Marques Guilherme

  2. Faculdade de Medicina Dentária da Universidade de Lisboa, Campus Universitário, 1649-003, Lisbon, Portugal

    Duarte Nuno da Silva Marques

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  1. Duarte Nuno da Silva Marques
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  2. António Duarte Sola Pereira da Mata
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  3. João Miguel Lourenço Silveira
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  4. Joana Rita Oliveira Faria Marques
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  5. João Pedro de Almeida Rato Amaral
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  6. Nuno Filipe Rito Parada Marques Guilherme
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Correspondence to Duarte Nuno da Silva Marques.

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da Silva Marques, D.N., da Mata, A.D.S.P., Silveira, J.M.L. et al. Hydrogen peroxide release kinetics into saliva from different whitening products: a double-blind, randomized clinical trial. Clin Oral Invest 16, 155–163 (2012). https://doi.org/10.1007/s00784-010-0491-x

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  • DOI: https://doi.org/10.1007/s00784-010-0491-x

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