Abstract
The thermodynamic parameters enthalpy and entropy of the interaction between calcium(II) or copper(II) with 5′-UMP, 5′-CMP, 5′-AMP, 5′-GMP or 5′-IMP in aqueous solution were determined calorimetrically (ionic strength adjusted to 0.1 with tetramethylammonium bromide) at 25 °C and pH 7 for Ca(II) or pH 3–5 for Cu(II). The experimental conditions were carefully selected to avoid polynuclear complex formation and nucleotide self-stacking. The calorimetric data confirm the tendency toward macrochelation which was indicated by Sigel after very precise potentiometric studies, and which follows the order Cu(II)>Ca(II) for the metal ions and GMP>IMP>AMP>CMP=UMP for the nucleotides. Macrochelate formation for these metal-nucleoside monophosphate complexes is energetically favorable and entropically unfavorable.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 13 August 1999 / Accepted: 1 February 2000
Rights and permissions
About this article
Cite this article
Herrero, L., Terrón, A. Interactions in solution of calcium(II) and copper(II) with nucleoside monophosphates: a calorimetric study. JBIC 5, 269–275 (2000). https://doi.org/10.1007/s007750050371
Issue Date:
DOI: https://doi.org/10.1007/s007750050371