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The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women

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A Correction to this article was published on 19 November 2019

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Abstract

To evaluate whether or not the urinary pentosidine level has clinical value in the assessment of the osteoporotic fracture risk, a novel ELISA for pentosidine was used in clinical samples. This study employed a cross-sectional design to analyze a subset of postmenopausal women in the Nagano Cohort Study. A total of 517 urine samples were analyzed using an ELISA system, which can measure urinary pentosidine without hydrolysis. Patients were asked about their history of non-vertebral osteoporotic fracture and the prevalence of vertebral fracture was semi-quantitatively assessed on X-ray films. A 10-year increase in age was related to a 1.09-fold increase in the urinary pentosidine level (95% CI 1.05–1.13, P < 0.001), prevalent fracture (+) was related to a 1.10-fold increase in the urinary pentosidine level (95% CI 1.03–1.18, P = 0.006). Patients with prevalent fracture who had a normal bone mineral density (BMD) showed higher pentosidine levels (median 34.3 pM/mg Cr) than patients with a low BMD without fracture (median 31.4 pM/mg Cr). A multivariable logistic regression analysis revealed that urinary pentosidine was significantly associated with the prevalence of fracture after adjustment for known risk factors for fracture (odds ratio 1.92, 95% CI 1.09–3.37, P = 0.023). The present results indicated a significant association between urinary pentosidine and fracture after adjustment for age and BMD, suggesting that urinary pentosidine may be useful for assessing the fracture risk in postmenopausal women.

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Change history

  • 19 November 2019

    In the original publication of the article, the following sentence under the abstract section was published incorrectly as “A multivariable logistic regression analysis revealed that urinary pentosidine was significantly associated with the prevalence of fracture after adjustment for known risk factors for fracture (odds ratio 1.92, 95% CI 1.09–3.37, <Emphasis Type="Italic">P </Emphasis>= 0.023).”

  • 19 November 2019

    In the original publication of the article, the following sentence under the abstract section was published incorrectly as ���A multivariable logistic regression analysis revealed that urinary pentosidine was significantly associated with the prevalence of fracture after adjustment for known risk factors for fracture (odds ratio 1.92, 95% CI 1.09���3.37, P���=���0.023).���

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Acknowledgements

The authors would like to thank the patients who agreed to participate in the present project. The authors would also like to thank Dr. Brian Quinn for editing the English of this paper.

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Authors and Affiliations

  1. Research Institute and Practice for Involutional Diseases, 1610-1, Meisei, Misato, Azumino, Nagano Prefecture, 399-8101, Japan

    Masataka Shiraki

  2. Research and Development, SB Bioscience Co., Ltd., Osaka, Japan

    Shoji Kashiwabara

  3. Department of Clinical Biostatistics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Takumi Imai & Shiro Tanaka

  4. Department of Orthopedic Surger, Jikei University School of Medicine, Tokyo, Japan

    Mitsuru Saito

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  1. Masataka Shiraki
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  2. Shoji Kashiwabara
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  3. Takumi Imai
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  4. Shiro Tanaka
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  5. Mitsuru Saito
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Correspondence to Masataka Shiraki.

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Conflict of interest

MS received consultant fee from Teijin pharma and Asahi Kasei Pharma, a manufacturer of drugs to treat osteoporosis. SK is an employee of SB Bioscience Co., Ltd. TI, ST, and MiS declare no conflicts of interest in association with the present study.

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Shiraki, M., Kashiwabara, S., Imai, T. et al. The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women. J Bone Miner Metab 37, 1067–1074 (2019). https://doi.org/10.1007/s00774-019-01017-9

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  • DOI: https://doi.org/10.1007/s00774-019-01017-9

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