Abstract
Aβ-2M-amyloidosis is a type of systemic amyloidosis that is specifically seen in patients with chronic kidney diseases. The precursor protein of Aβ-2M-amyloid fibril is β2-microglobulin, and its elevated serum level is the main cause of Aβ-2M-amyloidosis in patients with kidney failure. However, the precise mechanism of Aβ-2M-amyloidogenesis remains unclear. In vitro analyses of Aβ-2M amyloidogenesis are still being actively conducted. Osteolytic lesions are often found around synovial membrane with Aβ-2M-amyloid deposition. Both evident osteoclastogenesis and active osteoclastic bone resorption are found, while osteoblastic bone formation is absent in the lesion most likely associated with the inflammation caused by infiltrating macrophages/monocytes into Aβ-2M-amyloid deposition. The precise cell biological mechanism of this inflammatory change is unknown. Further studies are needed to establish specific treatments against this as yet unsolved problem with long-term dialysis therapy.
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References
F Gejyo I Narita (2003) ArticleTitleCurrent clinical and pathogenetic understanding of beta-2-m-amyloidosis in long-term haemodialysis patients Nephrology 8 IssueIDSuppl S45–49 Occurrence Handle15012691
F Gejyo T Yamada S Odani Y Nakagawa M Arakawa T Kunitomo H Kataoka M Suzuki Y Hirasawa T Shirahama (1985) ArticleTitleA new form of amyloid protein associated with chronic hemodialysis was identified as beta-2-microglobulin Biochem Biophys Res Commun 129 701–706 Occurrence Handle10.1016/0006-291X(85)91948-5 Occurrence Handle1:CAS:528:DyaL2MXksFahsb0%3D Occurrence Handle3893430
JJ Kazama H Maruyama F Gejyo (2001) ArticleTitleReduction of circulating beta-2-microglobulin level for the treatment of dialysis-related amyloidosis Nephrol Dial Transplant 16 IssueIDSuppl 4 31–35 Occurrence Handle1:CAS:528:DC%2BD3MXlslWhu7s%3D Occurrence Handle11402095
D Sethi PE Gower (1986) ArticleTitleSynovial-fluid beta-2-microglobulin levels in dialysis arthropathy N Engl J Med 315 1419–1420 Occurrence Handle1:STN:280:BiiD3sbislI%3D Occurrence Handle3095642
S Yamamoto I Yamaguchi K Hasegawa S Tsutsumi Y Goto F Gejyo H Naiki (2004) ArticleTitleGlycosaminoglycans enhance the trifluoroethanol-induced extension of beta-2-microglobulin-related amyloid fibrils at a neutral pH J Am Soc Nephrol 15 126–133 Occurrence Handle10.1097/01.ASN.0000103228.81623.C7 Occurrence Handle1:CAS:528:DC%2BD2cXhs1ahsw%3D%3D Occurrence Handle14694164
I Yamaguchi H Suda N Tsuzuike K Seto M Seki Y Yamaguchi K Hasegawa N Takahashi S Yamamoto F Gejyo H Naiki (2003) ArticleTitleGlycosaminoglycan and proteoglycan inhibit the depolymerization of beta-2-microglobulin amyloid fibrils in vitro Kidney Int 64 1080–1088 Occurrence Handle10.1046/j.1523-1755.2003.00167.x Occurrence Handle1:CAS:528:DC%2BD3sXntl2mu78%3D Occurrence Handle12911560
M Kihara E Chatani M Sakai K Hasegawa H Naiki Y Goto (2005) ArticleTitleSeeding-dependent maturation of beta-2-microglobulin amyloid fibrils at neutral pH J Biol Chem 280 12012–12018 Occurrence Handle10.1074/jbc.M411949200 Occurrence Handle1:CAS:528:DC%2BD2MXisVyju7c%3D Occurrence Handle15659393
JJ Kazama M Arakawa F Gejyo (1998) ArticleTitleSynovial inflammatory cells captured 131I-beta 2-microglobulin in patients with dialysis-related amyloidosis Amyloid 5 24–29 Occurrence Handle1:STN:280:DyaK1c7otFKitw%3D%3D Occurrence Handle9547002
JJ Kazama H Maruyama F Gejyo (2001) ArticleTitleOsteoclastogenesis and osteoclast activation in dialysis-related amyloid osteopathy Am J Kidney Dis 38 4 IssueIDSuppl 1 S156–S160
F Gejyo H Maruyama T Teramura J Kazama I Ei M Arakawa (1995) ArticleTitleRole of macrophages in beta-2-microglobulin-related dialysis amyloidosis Contrib Nephrol 112 97–104 Occurrence Handle1:CAS:528:DyaK2MXosVCntbo%3D Occurrence Handle7554998
I Blasko M Stampfer-Kountchev P Robatscher R Veerhuis P Eikelenboom B Grubeck-Loebenstein (2004) ArticleTitleHow chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes Aging Cell 3 169–176 Occurrence Handle10.1111/j.1474-9728.2004.00101.x Occurrence Handle1:CAS:528:DC%2BD2cXms1eitL8%3D Occurrence Handle15268750
T Miyata R Inagi Y Iida M Sato N Yamada O Oda K Maeda H Seo (1994) ArticleTitleInvolvement of beta-2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1 J Clin Invest 93 521–528 Occurrence Handle1:CAS:528:DyaK2cXis1yjtbs%3D Occurrence Handle8113390
T Miyata K Notoya K Yoshida K Horie K Maeda K Kurokawa S Taketomi (1997) ArticleTitleAdvanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles J Am Soc Nephrol 8 260–270 Occurrence Handle1:CAS:528:DyaK2sXhvV2hu7w%3D Occurrence Handle9048345
T Niwa S Miyazaki T Katsuzaki N Tatemichi Y Takei T Miyazaki T Morita Y Hirasawa (1995) ArticleTitleImmunohistochemical detection of advanced glycation end products in dialysis-related amyloidosis Kidney Int 48 771–778 Occurrence Handle1:CAS:528:DyaK2MXosF2nt74%3D Occurrence Handle7474663
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Kazama, J., Yamamoto, S., Takahashi, N. et al. Aβ-2M-amyloidosis and related bone diseases. J Bone Miner Metab 24, 182–184 (2006). https://doi.org/10.1007/s00774-005-0669-5
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DOI: https://doi.org/10.1007/s00774-005-0669-5