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Bakterielle Besiedlung der atheromatösen Plaques

Parodontitis und Arteriosklerose

Bacterial colonization of atheromatous plaques

Periodontitis and arteriosclerosis

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Zusammenfassung

In der vorliegenden Studie wurden von 62 Patienten (18 Frauen und 44 Männer) 93 Proben aus verschiedensten Gefäßen und Gefäßabschnitten während der Gefäßoperation entnommen und auf bakterielle 16S rDNS sowie—mittels spezifischen Oligonukleotidprimern—auf die mit Parodontitis assoziierten Keime P. gingivalis, P. intermedia, A. actinomycetemcomitans, C. rectus und B. forsythus untersucht. In 76,34% der 93 untersuchten Gefäßwandpräparate waren Bakterien nachzuweisen, in 40,86% einer oder mehrere der parodontalpathogenen Erreger. Diese kamen so gut wie immer (mit einer Ausnahme) zusammen mit anderen Bakterien vor.

C. pneumoniae fanden sich in 22,58% der Proben. Ihr Auftreten stand signifikant mit dem Vorkommen von parodontalpathogenen Keimen in Zusammenhang. Herpes-simplex- und Zytomegalieviren kamen in 24,73% bzw. 30,11% der Proben vor, ohne dass ein Zusammenhang mit Parodontalkeimen bestand.

Diese Ergebnisse stehen im Einklang mit der Hypothese, dass Mikroorganismen, die mit Parodontitis assoziiert sind, bei der Ätiologie und Pathogenese der Arteriosklerose eine wichtige Rolle spielen.

Abstract

The present study examined 93 atheromas from 62 German subjects including 18 women and 44 men between the ages of 43 and 89 years. Atheromas obtained during surgery were examined for bacterial 16S rDNA and—using specific oligonucleotide primers for bacterial 16S ribosomal RNA—for the periodontal pathogens A. actinomycetemcomitans, B. forsythus, P. gingivalis, P. intermedia, and C. rectus, respectively. Of the 93 endarterectomy specimens, 76.34% were positive for bacterial 16S rDNA, and 40.86% were positive for at least one of the target periodontal pathogens. Periodontal pathogens occurred in specimens together with other bacteria with only one exception.

C. pneumoniae were detected in 22.58% of the specimens; there was a significant correlation with the occurrence of periodontal pathogens. Herpes simplex and cytomegaloviruses were present in 24.73% or 30.11% of the specimens, respectively, without a link to periodontal pathogens.

This study is consistent with the hypothesis that oral infection plays a role in atherogenesis.

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Danksagung:

Die Autoren bedanken sich bei der Firma Schwarz Pharma für die finanzielle Unterstützung dieser Studie.

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

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Authors and Affiliations

  1. Chirurgische Klinik, Städtisches Krankenhaus Heinsberg

    N. Mastragelopulos

  2. Poliklinik für Zahnerhaltungskunde und Parodontologie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin

    S. Rogge, A. M. Kielbassa & G.-G. K. Zafiropoulos

  3. Departments of Periodontology, Restorative Dentistry and Oral Biology/Research Center, State University of New York at Buffalo, Buffalo, New York, USA

    V. I. Haraszthy, J. J. Zambon & G.-G. K. Zafiropoulos

  4. IPPZ-Institut für Parodontologie und Präventive Zahnmedizin, Düsseldorf

    C. Beaumont & G.-G. K. Zafiropoulos

  5. Zentrum für Gefäßchirurgie, Universität zu Köln

    N. Mastragelopulos & J. Brunkwall

  6. Chirurgische Klinik, Städtisches Krankenhaus Heinsberg, Auf dem Brand 1, 52525, Heinsberg

    N. Mastragelopulos

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  1. N. Mastragelopulos
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Mastragelopulos, N., Rogge, S., Kielbassa, A.M. et al. Bakterielle Besiedlung der atheromatösen Plaques. Gefässchirurgie 9, 332–338 (2004). https://doi.org/10.1007/s00772-004-0365-0

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