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Die Silikon-beschichtete Polyester-Prothese

Weiterführende Modifikationen und Vorstellung des „drug releasing graft“

The silicone coated polyester prosthesis

Further modifications and introduction of the “drug releasing graft”

  • Intimahyperplasie
  • Published:
Gefässchirurgie Aims and scope Submit manuscript

Zusammenfassung

Hintergrund

Wir berichten über die Entwicklung einer multifunktionellen, silikonbeschichteten Polyesterprothese.

Material und Methoden

Herkömmliche Polyesterprothesen wurden mit Silikon beschichtet. Es folgte eine Oberflächenmodifizierung mit unterschiedlichen Molekülen. Anschließend wurden Substanzen in die Matrix des Silikons eingebracht, die wieder abgegeben werden können. Die Prothesen wurden hinsichtlich ihrer physikalischen und biologischen Eigenschaften analysiert.

Ergebnisse

In ihren physikalischen Charakteristika, wie z. B. Dichtigkeit, Compliance und Steifigkeit, ist eine mit 16–20 mg/cm2 Silikon-beschichtete Prothese mit herkömmlichen Materialien vergleichbar. Bei der Thrombogenität zeigten die Polyvinylalkohol- und phosphocholinmodifizierten Prothesen Vorteile. Die eluierten Substanzen wurden je nach Eigenschaften entweder bevorzugt ins Medium (ASS) oder in angrenzendes Gewebe abgegeben (Sudanrot, Sirolimus, weiteres Immunsuppressivum). Im Tierversuch konnte durch die Abgabe der Substanzen ein Effekt auf die Intimahyperplasie demonstriert werden.

Schlussfolgerung

Die hier vorgestellte Prothese ist hinsichtlich ihrer Eigenschaften beliebig modifizierbar. Neben der Verbesserung der Hämokompatibilität steht mit der Elution von Molekülen ein geeignetes Instrument zur lokalen Medikamentenfreisetzung zur Verfügung.

Abstract

Background

Herein we report on the development of a multifunctional, silicone-coated polyester graft.

Methods

Normal polyester prostheses were coated with silicone. Afterwards, the surface was modified with different functional groups. In addition, substances with the aim of elution were incorporated into the bulk of the silicone. We analyzed these grafts regarding their physical and biological properties.

Results

Physical and biological characteristics (such as density, compliance, and stiffness) of a polyester graft coated with 16–20 mg silicone/cm2 are comparable to a normal prosthesis. In surface modification, polyvinylalcohol and phosphocholine-modified materials showed advantages regarding thrombogenicity. The eluted molecules could be found preferentially in the medium used (ASS) or in the tissue adjacent to the bypass (Sudan red, sirolimus, and another immunosuppressive drug). In the animal study, the elution of the substances was demonstrated by the effect on the intimal hyperplasia.

Conclusions

The prosthesis presented in this paper may be modified in many ways. Besides optimizing the hemocompatibility, the elution of molecules offers a tremendous tool for local drug release.

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Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

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Authors and Affiliations

  1. Abteilung für Gefäßchirurgie, Endovaskuläre Chirurgie, Chirurgische Klinik und Poliklinik, Universitätsklinik Würzburg

    A. Larena-Avellaneda, C. Körner, U. A. Dietz, S. Franke & A. Thiede

  2. Abteilung für Allgemein- Gefäß- und Viszeralchirurgie, Allgemeines Krankenhaus Harburg

    E. S. Debus

  3. bionic surfaces

    R. Siegel

  4. Abteilung für Gefäßchirurgie, Endovaskuläre Chirurgie, Chirurgische Klinik und Poliklinik, Universitätsklinik Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg

    A. Larena-Avellaneda

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  1. A. Larena-Avellaneda
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  2. E. S. Debus
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  3. R. Siegel
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  4. C. Körner
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  5. U. A. Dietz
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  6. S. Franke
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  7. A. Thiede
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Correspondence to A. Larena-Avellaneda.

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Larena-Avellaneda, A., Debus, E.S., Siegel, R. et al. Die Silikon-beschichtete Polyester-Prothese. Gefässchirurgie 9, 105–110 (2004). https://doi.org/10.1007/s00772-004-0340-9

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  • DOI: https://doi.org/10.1007/s00772-004-0340-9

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