Abstract
The choice of the reference, either as internal or external is not straightforward in quantitative NMR. In this context ERETIC™ methodology appears as an universal referencing technique. An electronic signal, generated by the NMR spectrometer during the acquisition time, operates as a virtual working standard. The processes for ensuring a traceability to primary standards is illustrated on the official method devoted to (D/H)i ratios measurement on ethanol, using quantitative 2H-NMR. The ERETIC approach is shown to be equivalent to its official homologue, in terms of accuracy and precision. Finally, its performance could be beneficial to other analytes, matrices and nuclei.
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We are grateful to Dr R. Robins for reviewing the manuscript and for fruitful discussions.
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Remaud, G.S., Silvestre, V. & Akoka, S. Traceability in quantitative NMR using an electronic signal as working standard. Accred Qual Assur 10, 415–420 (2005). https://doi.org/10.1007/s00769-005-0044-1
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DOI: https://doi.org/10.1007/s00769-005-0044-1