Zusammenfassung
Die letzten drei Jahrzehnte waren charakterisiert durch eine bemerkenswerte Expansion diagnostischer und therapeutischer Optionen im Zusammenhang mit bipolar affektiven Störungen. Aktuell kann eine Konsolidierungsphase beobachtet werden mit weniger – vor allem pharmakologischen – Innovationen. Das vorliegende Manuskript widmet sich drei Fragen: Was gibt es Neues zur Diagnostik? Was gibt es Neues zur Pharmakotherapie? Was gibt es Neues zur Psychotherapeutischen Medizin? Die Fragen werden beantwortet, indem jeweils ein besonderer Aspekt hervorgehoben wird: die neue Klassifikation der Mischzustände im DSM-5, die Verwendung von Loxapin als Inhalat in der Therapie der Agitation und der Einsatz der „mindfulness-based cognitive therapy“ (MBCT) bei bipolaren Störungen.
Abstract
The last 3 decades were characterized by a remarkable expansion of diagnostic and therapeutic options in bipolar affective disorders. Recently, a phase of consolidation with less—particularly pharmacologic—innovation can be observed. In the present manuscript three questions are addressed: What’s new about diagnosis? What’s new about pharmacotherapy? What’s new about psychotherapeutic medicine? The questions are answered by highlighting one particular aspect each: the new classification of mixed states in DSM-5, the application of loxapine by inhalatory route in agitation and the use of mindfulness-based cognitive therapy in bipolar disorder.
Literatur
Vieta E, Berk M, Schulze TG, Carvalho AF, Suppes T, Calabrese JR, Gao K, Miskowiak KW, Grande I (2018) Bipolar disorders. Nat Rev Dis Primers 4:18008
Cullen B, Ward J, Graham NA, Deary IJ, Pell JP, Smith DJ, Evans JJ (2016) Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: a systematic review. J Affect Disord 205:165–181
Vigo D, Thornicroft G, Atun R (2016) Estimating the true global burden of mental illness. Lancet Psychiatry 3:171–178
Unseld M, Dworschak G, Tran US, Plener PL, Erfurth A, Walter H, Lesch OM, Kapusta ND (2012) The concept of temperament in psychoactive substance use among college students. J Affect Disord 141(2–3):324–330
Naderer A, Keller F, Plener P, Unseld M, Lesch OM, Walter H, Erfurth A, Kapusta ND (2015) The brief TEMPS-M temperament questionnaire: a psychometric evaluation in an Austrian sample. J Affect Disord 188:43–46
Skala K, Riegler A, Erfurth A, Völkl-Kernstock S, Lesch OM, Walter H (2016) The connection of temperament with ADHD occurrence and persistence into adulthood—an investigation in 18 year old males. J Affect Disord 198:72–77
Shahini M, Shala M, Xhylani P, Gashi S, Borinca I, Erfurth A (2018) Challenging predictions between affective temperaments, depression and anxiety in a Kosovo student community sample. Int J Psychiatry Clin Pract 26:1–7
Vannucchi G, Masi G, Toni C, Dell’Osso L, Erfurth A, Perugi G (2014) Bipolar disorder in adults with Asperger’s Syndrome: a systematic review. J Affect Disord 168:151–160
Sachs G, Erfurth A (2018) Obsessive compulsive and related disorders: from the biological basis to a rational pharmacological treatment. Int J Neuropsychopharmacol 21(1):59–62
Calabrese JR, Shelton MD, Bowden CL, Rapport DJ, Suppes T, Shirley ER, Kimmel SE, Caban SJ (2001) Bipolar rapid cycling: focus on depression as its hallmark. J Clin Psychiatry 62(Suppl 14):34–41
Erfurth A, Perugi G (2005) Rapid cycling. In: Kasper S, Hirschfeld RMA (Hrsg) Handbook of bipolar disorder. Marcel Dekker, Taylor & Francis Books, Inc, Abingdon, S 201–212
Michael N, Erfurth A, Pfleiderer B (2009) Elevated metabolites within dorsolateral prefrontal cortex in rapid cycling bipolar disorder. Psychiatry Res Neuroimag 172(1):78–81
Carvalho AF, Dimellis D, Gonda X, Vieta E, Mclntyre RS, Fountoulakis KN (2014) Rapid cycling in bipolar disorder: a systematic review. J Clin Psychiatry 75(6):e578–86
Erfurth A, Arolt V (2003) Das Spektrum bipolarer Störungen. Nervenarzt 73:55–71
Weygandt W (1899) Über die Mischzustände des manisch-depressiven Irreseins. Lehmann, München
Kraepelin E (1899) Psychiatrie, 6. Aufl. Barth, Leipzig
Erfurth A (2004) Agitated depression is bipolar. PRO. J Bipolar Disord Rev Comment 3:4–14
Erfurth A, Sachs G, Perugi G, Tondo L (2014) Athanasios Koukopoulos (1931–2013). Zum Verlauf manisch-depressiver Erkrankungen. Psychoprax Neuroprax 17:5–8
Perugi G, Angst J, Azorin JM, Bowden CL, Mosolov S, Reis J, Vieta E, Young AH, BRIDGE-II-Mix Study Group (2015) Mixed features in patients with a major depressive episode: the BRIDGE-II-MIX study. J Clin Psychiatry 76(3):e351–8
American Psychiatric Association (2013) The diagnostic and statistical manual of mental disorders: DSM-5
Erfurth A, Sachs G (2015) Mischzustände, Mischbilder und die depressive Episode mit gemischten Merkmalen. Psychoprax Neuroprax 18(2):38–43
Kasper S, Kapfhammer HP, Bach M, Butterfield-Meissl C, Erfurth A, Haring C, Hausmann A, Hofmann P, Kalousek M, Klier C, Marksteiner J, Mühlbacher M, Oberlerchner H, Psota G, Rados C, Sachs GM, Windhager E, Winkler J, Wrobel M (2013) Bipolare Störungen. Konsensus-Statement—State of the art 2013. CliniCum neuropsy Sonderausgabe November, S 3–18
Erfurth A, Grunze H (1998) New perspectives in the treatment of acute mania: a single case report. Prog Neuropsychopharmacol Biol Psychiatry 22(6):1053–1059
Erfurth A, Kuhn G (2000) Topiramate monotherapy in the maintenance treatment of bipolar I disorder: effects on mood, weight and serum lipids. Neuropsychobiology 42(Suppl 1):50–51
Kasper S, Baranyi A, Eisenburger P, Erfurth A, Ertl M, Frey R, Hausmann A, Kapfhammer HP, Roitner-Vitzthum E, Konsensus-Statement WD (2013) Die Behandlung der Agitation beim psychiatrischen Notfall. CliniCum neuropsy Sonderausgabe November, S 3–15
Brown R, Taylor MJ, Geddes J (2013) Aripiprazole alone or in combination for acute mania. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD005000.pub2
Grande I, Hidalgo-Mazzei D, Nieto E, Mur M, Sàez C, Forcada I, Vieta E (2015) Asenapine prescribing patterns in the treatment of manic in- and outpatients: results from the MANACOR study. Eur Psychiatry 30(4):528–534
Popovic D, Nuss P, Vieta E (2015) Revisiting loxapine: a systematic review. Ann Gen Psychiatry 14:15
Vieta E, Grunze H, Azorin JM, Fagiolini A (2014) Phenomenology of manic episodes according to the presence or absence of depressive features as defined in DSM-5: results from the IMPACT self-reported online survey. J Affect Disord 156:206–213
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33
Hergueta T, Weiller E (2013) Evaluating depressive symptoms in hypomanic and manic episodes using a structured diagnostic tool: validation of a new Mini International Neuropsychiatric Interview (M.I.N.I.) module for the DSM-5 „With Mixed Features“ specifier. Int J Bipolar Disord 1:21
Lesem MD, Tran-Johnson TK, Riesenberg RA, Feifel D, Allen MH, Fishman R, Spyker DA, Kehne JH, Cassella JV (2011) Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. Br J Psychiatry 198(1):51–58
Kwentus J, Riesenberg RA, Marandi M, Manning RA, Allen MH, Fishman RS, Spyker DA, Kehne JH, Cassella JV (2012) Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine. Bipolar Disord 14(1):31–40
Amodeo G, Fagiolini A, Sachs G, Erfurth A (2017) Older and newer strategies for the pharmacological management of agitation in patients with bipolar disorder or schizophrenia. Cns Neurol Disord Drug Targets 16(8):885–890
Erfurth A (2017) Agitation: a central challenge in psychiatry. World J Biol Psychiatry 18(1):3–4
Kasper S, Di Pauli J, Erfurth A, Geretsegger C, Kapfhammer HP, Papageorgiou K, Sachs GM, Wrobel M (2015) Inhalatives Loxapin – Praxiserfahrungen nach dem ersten Anwendungsjahr. CliniCum neuropsy Sonderausgabe 2015
Glazer WM (1999) Does loxapine have „atypical“ properties? Clinical evidence. J Clin Psychiatry 60(Suppl 10):42–46
Spyker DA, Munzar P, Cassella JV (2010) Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers. J Clin Pharmacol 50(2):169–179
Schaub A, Bernhard B, Gauck L (2004) Kognitiv-psychoedukative Therapie bei bipolaren Erkrankungen: Ein Therapiemanual. Hogrefe, Göttingen
Erfurth A, Dobmeier G, Zechendorff M (2005) Kurzpsychoedukation für bipolare Patienten: das einfache Kurzprogramm in 6 Modulen. Thieme, Stuttgart
Meyer TD, Bipolare Störungen HM (2013) Kognitiv-verhaltenstherapeutisches Behandlungsmanual. Beltz, Weinheim
Salcedo S, Gold AK, Sheikh S, Marcus PH, Nierenberg AA, Deckersbach T, Sylvia LG (2016) Empirically supported psychosocial interventions for bipolar disorder: current state of the research. J Affect Disord 201:203–214
Vieta E, Torrent C (2016) Functional remediation: the pathway from remission to recovery in bipolar disorder. World Psychiatry 15:288–289
Sachs G, Felsberger H (2013) Mentalisierungsbasierte Psychotherapie bei schizophrenen Psychosen. Psychotherapeut 58(4):339–343
Sachs G, Volz HP (Hrsg) (2012) Neurokognition und Affektregulierung bei schizophrenen Psychosen: Neuropsychologie, Bildgebung, Testdiagnostik und Behandlung. Schattauer, Stuttgart
Goldapple K, Segal Z, Garson C, Lau M, Bieling P, Kennedy S, Mayberg H (2004) Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. Arch Gen Psychiatry 61(1):34–41
Ye BY, Jiang ZY, Li X, Cao B, Cao LP, Lin Y, Xu GY, Miao GD (2016) Effectiveness of cognitive behavioral therapy in treating bipolar disorder: an updated meta-analysis with randomized controlled trials. Psychiatry Clin Neurosci 70(8):351–361
Luders E, Toga AW, Lepore N, Gaser C (2009) The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter. Neuroimage 45(3):672–678
Luders E, Thompson PM, Kurth F, Hong JY, Phillips OR, Wang Y, Gutman BA, Chou YY, Narr KL, Toga AW (2013) Global and regional alterations of hippocampal anatomy in long-term meditation practitioners. Hum Brain Mapp 34(12):3369–3375
Tang YY, Lu Q, Feng H, Tang R, Posner MI (2015) Short-term meditation increases blood flow in anterior cingulate cortex and insula. Front Psychol 6:212
Segal ZV, Bieling P, Young T, MacQueen G, Cooke R, Martin L, Bloch R, Levitan RD (2010) Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry 67(12):1256–1264
Piet J, Hougaard E (2011) The effect of mindfulness-based cognitive therapy for prevention of relapse in recurrent major depressive disorder: a systematic review and meta-analysis. Clin Psychol Rev 31(6):1032–1040
Kuyken W, Hayes R, Barrett B, Byng R, Dalgleish T, Kessler D, Lewis G, Watkins E, Brejcha C, Cardy J, Causley A, Cowderoy S, Evans A, Gradinger F, Kaur S, Lanham P, Morant N, Richards J, Shah P, Sutton H, Vicary R, Weaver A, Wilks J, Williams M, Taylor RS, Byford S (2015) Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial. Lancet 386(9988):63–73
Williams JM, Alatiq Y, Crane C, Barnhofer T, Fennell MJ, Duggan DS, Hepburn S, Goodwin GM (2008) Mindfulness-based Cognitive Therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning. J Affect Disord 107(1–3):275–279
Weber B, Jermann F, Gex-Fabry M, Nallet A, Bondolfi G, Aubry JM (2010) Mindfulness-based cognitive therapy for bipolar disorder: a feasibility trial. Eur Psychiatry 25(6):334–337
Deckersbach T, Hölzel BK, Eisner LR, Stange JP, Peckham AD, Dougherty DD, Rauch SL, Lazar S, Nierenberg AA (2012) Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorder. CNS Neurosci Ther 18(2):133–141
Stange JP, Eisner LR, Hölzel BK, Peckham AD, Dougherty DD, Rauch SL, Nierenberg AA, Lazar S, Deckersbach T (2011) Mindfulness-based cognitive therapy for bipolar disorder: effects on cognitive functioning. J Psychiatr Pract 17(6):410–419
Perich T, Manicavasagar V, Mitchell PB, Ball JR, Hadzi-Pavlovic D (2013) A randomized controlled trial of mindfulness-based cognitive therapy for bipolar disorder. Acta Psychiatr Scand 127(5):333–343
Perich T, Manicavasagar V, Mitchell PB, Ball JR (2013) The association between meditation practice and treatment outcome in mindfulness-based cognitive therapy for bipolar disorder. Behav Res Ther 51(7):338–343
Ives-Deliperi VL, Howells F, Stein DJ, Meintjes EM, Horn N (2013) The effects of mindfulness-based cognitive therapy in patients with bipolar disorder: a controlled functional MRI investigation. J Affect Disord 150(3):1152–1157
Cotton S, Luberto CM, Sears RW, Strawn JR, Stahl L, Wasson RS, Blom TJ, Delbello MP (2016) Mindfulness-based cognitive therapy for youth with anxiety disorders at risk for bipolar disorder: a pilot trial. Early Interv Psychiatry 10(5):426–434
Lahera G, Bayón C, Bravo-Ortiz FM, Rodríguez-Vega B, Barbeito S, Sáenz M, Avedillo C, Villanueva R, Ugarte A, González-Pinto A, de Dios C (2014) Mindfulness-based cognitive therapy versus psychoeducational intervention in bipolar outpatients with sub-threshold depressive symptoms: a randomized controlled trial. BMC Psychiatry 14:215
Joshi SS, Sharma MP, Varambally S (2018) Effectiveness of mindfulness-based cognitive therapy in patients with bipolar affective disorder: a case series. Int J Yoga 11(1):77–82
Weber B, Sala L, Gex-Fabry M, Docteur A, Gorwood P, Cordera P, Bondolfi G, Jermann F, Aubry JM, Mirabel-Sarron C (2017) Self-reported long-term benefits of mindfulness-based cognitive therapy in patients with bipolar disorder. J Altern Complement Med 23(7):534–540
Bojic S, Becerra R (2017) Mindfulness-based treatment for bipolar disorder: a systematic review of the literature. Eur J Psychol 13(3):573–598
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
A. Erfurth erhielt Referentenhonorare beziehungsweise war im Beirat oder als Berater tätig für: Angelini, AOP Orphan, Eli Lilly, Ferrer, Germania, Krka, Lundbeck, Neuraxpharm, GlaxoSmithKline, Pfizer, Janssen. G. Sachs erhielt Referentenhonorare beziehungsweise war im Beirat oder als Berater tätig für: Angelini, AOP Orphan, Alkermes, Lundbeck, Pfizer, Janssen.
Dieser Beitrag stellt keine von den Autoren durchgeführte Studie an Menschen oder Tieren dar.
Rights and permissions
About this article
Cite this article
Erfurth, A., Sachs, G. Bipolare Störungen. psychopraxis. neuropraxis 21, 123–127 (2018). https://doi.org/10.1007/s00739-018-0470-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00739-018-0470-6