Abstract
Insomnia is a frequent climacteric symptom. This pilot, double-blind, randomized placebo-controlled trial compared estradiol associated with trimegestone or placebo in 12 women with perimenopausal insomnia. The Pittsburgh Sleep Quality Index (PSQI) was administered, and polysomnography was performed at baseline and after 28 days. Sleep efficiency and median score of the PSQI improved significantly in the hormone therapy group (HT) (p = 0.041 and p = 0.027, respectively) and not in placebo group. Perimenopausal insomnia improved after short-term HT.
References
Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213
Ensrud KE, Stone KL, Blackwell TL, Sawaya GF, Tagliaferri M, Diem SJ, Grady D (2009) Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes. Menopause 16(2):286–292. doi:10.1097/gme.0b013e31818c0485
Erlik Y, Tataryn IV, Meldrum DR, Lomax P, Bajorek JG, Judd HL (1981) Association of waking episodes with menopausal hot flushes. JAMA 245(17):1741–1744
Freedman RR, Roehrs TA (2007) Sleep disturbance in menopause. Menopause 14(5):826–829. doi:10.1097/GME.0b013e3180321a22
Gambacciani M, Ciaponi M, Cappagli B, Monteleone P, Benussi C, Bevilacqua G, Vacca F, Genazzani AR (2005) Effects of low-dose, continuous combined hormone replacement therapy on sleep in symptomatic postmenopausal women. Maturitas 50(2):91–97. doi:10.1016/j.maturitas.2004.04.006
Lenz MC, Martinez D (2007) Awakenings change results of nighttime ambulatory blood pressure monitoring. Blood Press Monit 12(1):9–15. doi:10.1097/MBP.0b013e3280858c70
Ohayon MM (2006) Severe hot flashes are associated with chronic insomnia. Arch Intern Med 166(12):1262–1268. doi:10.1001/archinte.166.12.1262
Polo-Kantola P, Erkkola R, Irjala K, Pullinen S, Virtanen I, Polo O (1999) Effect of short-term transdermal estrogen replacement therapy on sleep: a randomized, double-blind crossover trial in postmenopausal women. Fertil Steril 71(5):873–880
Pornel B, Spielmann D (2005) A study of the control of climacteric symptoms in postmenopausal women following sequential regimens of 1 mg 17beta-estradiol and trimegestone compared with a regimen containing 1 mg estradiol valerate and norethisterone over a two-year period. Gynecol Endocrinol 21(2):74–81
Schneider HP, Heinemann LA, Rosemeier HP, Potthoff P, Behre HM (2000) The Menopause Rating Scale (MRS): reliability of scores of menopausal complaints. Climacteric 3(1):59–64
Woods NF, Mitchell ES (2005) Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women's lives. Am J Med 118(Suppl 12B):14–24. doi:10.1016/j.amjmed.2005.09.031
Young T, Rabago D, Zgierska A, Austin D, Laurel F (2003) Objective and subjective sleep quality in premenopausal, perimenopausal, and postmenopausal women in the Wisconsin Sleep Cohort Study. Sleep 26(6):667–672
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Silva, B.H., Martinez, D. & Wender, M.C.O. A randomized, controlled pilot trial of hormone therapy for menopausal insomnia. Arch Womens Ment Health 14, 505–508 (2011). https://doi.org/10.1007/s00737-011-0242-2
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DOI: https://doi.org/10.1007/s00737-011-0242-2