Summary.
Despite the multitude of evidence for the beneficial effects of taurine supplementation in a variety of disease, the underlying modifying action of taurine with respect to either molecular or biochemical mechanisms is almost totally unknown. We have assessed the development of taurine analogues, particularly where there has been substitution at the suphonate or amine group. Such substitutions allow the investigator to probe the relationship between structure and function of the taurine molecule. In addition such studies should help to ascertain taurine's point of interaction with the effector molecule. These results will prepare the way for the development of the second generation of taurine analogues.
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Received January 2, 2002 Accepted January 28, 2002 Published online August 30, 2002
Acknowledgements This research has been funded by the COST Chemistry programmes COST D8 “Chemistry of Metals in Medicine” and D-13 “New Molecules for Human Health Care”. All of the authors are members of the Working Group D13/0011/00 “Investigation of mechanisms underlying the pharmacological actions of taurine upon cell apoptosis and calcium homeostasis”.
Authors' address: Dr. R.J. Ward, Unite de Biochimie, Catholic Universite de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium, E-mail: ward@bioc.ucl.ac.be
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Della Corte, L., Crichton, R., Duburs, G. et al. The use of taurine analogues to investigate taurine functions and their potential therapeutic applications. Amino Acids 23, 367–379 (2002). https://doi.org/10.1007/s00726-002-0210-2
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DOI: https://doi.org/10.1007/s00726-002-0210-2