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Specific effects and features of a combination of amine-containing antibacterial agents and silver nanoparticles stabilized by dicarboxylic acid copolymers

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Abstract

Various types of combinations of amine-containing antibacterial agents (heterocyclic and macrocyclic antibiotics, protein and peptide antibiotics, D-amino acids) and silver nanoparticles stabilized by dicarboxylic (maleic) acid copolymers (AgNPs) are obtained. The study demonstrated the specific action of the conjugates on the planktonic form of gram-positive and gram-negative microorganisms, and fungi. The antimicrobial properties of the conjugates depend on the structures of the AgNPs stabilizing shell, antibacterial agent, and the cell membrane of the pathogen. The polymer shell of the metal nanoparticles allowed to solubilize hydrophobic antibiotics due to the formation of covalent and non-covalent complexes. A pronounced synergistic antimicrobial effect was observed, when AgNPs were combined with hydrophobic amine-containing antibiotics: rifampin—against Staphylococcus aureus and amphotericin B—against Candida albicans. In these cases, the values of Fractional Inhibitory Concentration Indices were lower than 0.5. A pronounced positive bactericidal effect was observed, when using conjugates of AgNPs and a peptide antibiotic (vancomycin) against Enterococcus faecalis, as well as a protein (lysozyme) and D-amino acids against the variety of microorganisms.

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Acknowledgements

This work was performed with the financial support from Ministry of Science and Higher Education of the Russian Federation using the equipment of Center for molecular composition studies of INEOS RAS.

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Authors and Affiliations

  1. A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Moscow, 119991, Russian Federation

    Nadezhda Samoilova & Maria Krayukhina

  2. Federal State Budget Institution “A.N. Bakulev National Medical Research Center of Cardiovascular Surgery” of the Ministry of Health of the Russian, 135 Roublyevskoe Shosse, Moscow, 121552, Russian Federation

    Dmitry Popov & Nelya Anuchina

Authors
  1. Nadezhda Samoilova
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  2. Maria Krayukhina
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  3. Dmitry Popov
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  4. Nelya Anuchina
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Correspondence to Nadezhda Samoilova.

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Samoilova, N., Krayukhina, M., Popov, D. et al. Specific effects and features of a combination of amine-containing antibacterial agents and silver nanoparticles stabilized by dicarboxylic acid copolymers. Monatsh Chem 150, 2071–2080 (2019). https://doi.org/10.1007/s00706-019-02523-2

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