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Application of 2-chloro-4,6-dimethoxy-1,3,5-triazine in the synthesis of 2-azetidinones

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Abstract

A novel and convenient method for the conversion of imines and carboxylic acids into β-lactams using 2-chloro-4,6-dimethoxy-1,3,5-triazine at room temperature in dry dichloromethane is described. Optimization of the conditions was performed. This method is efficient and the water-soluble byproduct is removed by simple aqueous workup.

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Acknowledgments

Support for this work by the Rasht Branch of Islamic Azad University, is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Rasht Branch, Islamic Azad University, Rasht, Iran

    Arnoosh Khademi Shiraz

  2. Department of Chemistry, College of Sciences, Hormozgan University, Bandar Abbas, 71961, Iran

    Maaroof Zarei

Authors
  1. Arnoosh Khademi Shiraz
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  2. Maaroof Zarei
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Correspondence to Maaroof Zarei.

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Shiraz, A.K., Zarei, M. Application of 2-chloro-4,6-dimethoxy-1,3,5-triazine in the synthesis of 2-azetidinones. Monatsh Chem 146, 941–946 (2015). https://doi.org/10.1007/s00706-014-1354-y

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  • DOI: https://doi.org/10.1007/s00706-014-1354-y

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