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Kinetics and mechanism of reactions of some essential amino acids with cis-diaqua(1,3-diaminopropane)-platinum(II) ion: a potent anticancer agent

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Abstract

The substitution of both coordinated water molecules of cis-diaqua(1,3-diaminopropane)platinum(II) complex by a series of amino acids, viz. l-asparagine, l-glutamic acid, and glycine was investigated as a function of ligand concentration, temperature, and pH and found to occur in two consecutive reaction steps. The mechanism of the substitution reactions appears associative in nature as supported by the large and negative values of ΔS ≠. The kinetic study has been substantiated by product isolation, UV, IR, and ESI-MS spectroscopic analysis and rate parameters have been evaluated under different reaction conditions.

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Acknowledgments

One of the authors (Sumon Ray) is grateful to the University Grants Commission, New Delhi, India, for providing financial assistance and authors are also very much gratified to the Department of Chemistry, University of Burdwan, West Bengal, India, for infrastructural amenities.

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Authors and Affiliations

  1. Department of Chemistry, The University of Burdwan, Burdwan, 713104, West Bengal, India

    Sumon Ray, Debabrata Nandi, Animesh Chattopadhyay, Roshni Sarkar, Parnajyoti Karmakar & Alak K. Ghosh

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  1. Sumon Ray
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  2. Debabrata Nandi
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  3. Animesh Chattopadhyay
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  4. Roshni Sarkar
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  5. Parnajyoti Karmakar
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  6. Alak K. Ghosh
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Correspondence to Alak K. Ghosh.

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Ray, S., Nandi, D., Chattopadhyay, A. et al. Kinetics and mechanism of reactions of some essential amino acids with cis-diaqua(1,3-diaminopropane)-platinum(II) ion: a potent anticancer agent. Monatsh Chem 145, 1727–1735 (2014). https://doi.org/10.1007/s00706-014-1262-1

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  • DOI: https://doi.org/10.1007/s00706-014-1262-1

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