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One-pot three-component synthesis of β-acetamido carbonyl compounds catalyzed by heteropoly acids

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Abstract

A simple one-pot method for a new Mannich-type reaction is reported. In this method a heteropoly acid is used as a catalyst for the synthesis of β-acetamido carbonyl compounds via a three-component reaction of an aldehyde, acetamide, and dimedone in acetonitrile at room temperature. This method offers several advantages such as good yields, simple procedure, low cost, and ease of workup.

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Authors and Affiliations

  1. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

    Ali Javid

  2. Department of Chemistry, Alzahra University, Vanak, Tehran, Iran

    Majid M. Heravi

  3. Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    Fatemeh F. Bamoharram

Authors
  1. Ali Javid
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  2. Majid M. Heravi
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  3. Fatemeh F. Bamoharram
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Correspondence to Ali Javid.

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Javid, A., Heravi, M.M. & Bamoharram, F.F. One-pot three-component synthesis of β-acetamido carbonyl compounds catalyzed by heteropoly acids. Monatsh Chem 143, 831–834 (2012). https://doi.org/10.1007/s00706-011-0669-1

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  • DOI: https://doi.org/10.1007/s00706-011-0669-1

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