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A single-step, mild, neutral, catalyst-free method for cyanohydrin synthesis

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Abstract

A wide variety of carbonyl compounds can be transformed to their corresponding cyanohydrins in a single step using a dimethyl sulfoxide (DMSO)–water system in excellent yields (75–94%). The major advantages of this system are that the reaction conditions are mild and neutral; the reaction proceeds without catalyst and gives the corresponding cyanohydrins in short time (15–120 min).

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Acknowledgments

The authors N.H.P.D. and R.B. thank UGC, and M.D.K. thanks DBT, New Delhi for their financial support. Authors are grateful to Centaur Pharmaceuticals Pvt. Ltd. for recording NMR spectra.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India

    Mariam S. Degani, Manoj D. Kakwani, Nutan H. Palsule Desai & Ranjeet Bairwa

Authors
  1. Mariam S. Degani
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  2. Manoj D. Kakwani
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  3. Nutan H. Palsule Desai
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  4. Ranjeet Bairwa
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Correspondence to Mariam S. Degani.

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Degani, M.S., Kakwani, M.D., Palsule Desai, N.H. et al. A single-step, mild, neutral, catalyst-free method for cyanohydrin synthesis. Monatsh Chem 143, 461–465 (2012). https://doi.org/10.1007/s00706-011-0613-4

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  • DOI: https://doi.org/10.1007/s00706-011-0613-4

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