Skip to main content

Advertisement

SpringerLink
Log in

Emergent chikungunya fever and vertical transmission in Yunnan Province, China, 2019

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Abstract

During the dengue epidemic in Yunnan Province, China, during 2019, a concurrent outbreak of chikungunya occurred in the city of Ruili, which is located in the southwest of the province, adjacent to Myanmar. As part of this outbreak, three neonatal cases of infection with indigenous chikungunya virus from mother-to-child (vertical) transmission were observed. Isolates of chikungunya virus were obtained from 37 serum samples of patients with chikungunya during this outbreak, and a phylogenetic analysis of these isolates revealed that they belong to the Indian Ocean subclade of the East/Central/South African genotype. The E1 genes of these viruses did not harbor the A226V mutation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Availability of data and materials

The data supporting this study's findings are available on request from the corresponding author.

References

  1. Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT (2012) Chikungunya: a re-emerging virus. Lancet 379:662–671

    Article  Google Scholar 

  2. Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S (2017) Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen. Lancet Infect Dis 17:e107–e117

    Article  CAS  Google Scholar 

  3. Hammon WM, Rudnick A, Sather GE (1960) Viruses associated with epidemic hemorrhagic fevers of the Philippines and Thailand. Science 131:1102–1103

    Article  CAS  Google Scholar 

  4. Hermon YE (1967) Virological investigations of Arbovirus infections in Ceylon, with special reference to the recent Chikungunya fever epidemic. Ceylon Med J 12:81–92

    CAS  PubMed  Google Scholar 

  5. Hu TS, Zhang HL, Feng Y, Fan JH, Tang T, Liu YH, Zhang L, Yin XX, Chen G, Li HC, Zu J, Li HB, Li YY, Yu J, Zhang FQ, Fan QS (2017) Epidemiological and molecular characteristics of emergent dengue virus in Yunnan Province near the China-Myanmar-Laos border, 2013–2015. BMC Infect Dis 17:331

    Article  Google Scholar 

  6. Intayot P, Phumee A, Boonserm R, Sor-Suwan S, Buathong R, Wacharapluesadee S, Brownell N, Poovorawan Y, Siriyasatien P (2019) Genetic characterization of chikungunya virus in field-caught aedes aegypti mosquitoes collected during the recent outbreaks in 2019, Thailand. Pathogens 2019:8

    Google Scholar 

  7. Lee N, Wong CK, Lam WY, Wong A, Lim W, Lam CW, Cockram CS, Sung JJ, Chan PK, Tang JW (2006) Chikungunya fever, Hong Kong. Emerg Infect Dis 12:1790–1792

    Article  Google Scholar 

  8. Lumsden WH (1955) An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. II. General description and epidemiology. Trans R Soc Trop Med Hyg 49:33–57

    Article  CAS  Google Scholar 

  9. Melan A, Aung MS, Khanam F, Paul SK, Riaz BK, Tahmina S, Kabir MI, Hossain MA, Kobayashi N (2018) Molecular characterization of chikungunya virus causing the 2017 outbreak in Dhaka, Bangladesh. New Microbes New Infect 24:14–16

    Article  CAS  Google Scholar 

  10. Pan J, Fang C, Yan J, Yan H, Zhan B, Sun Y, Liu Y, Mao H, Cao G, Lv L, Zhang Y, Chen E (2019) Chikungunya fever outbreak, Zhejiang Province, China, 2017. Emerg Infect Dis 25:1589–1591

    Article  Google Scholar 

  11. Pavri KM (1964) Presence of Chikungunya antibodies in human sera collected from Calcutta and Jamshedpur before 1963. Indian J Med Res 52:698–702

    CAS  PubMed  Google Scholar 

  12. Robinson MC (1955) An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. I. Clinical features. Trans R Soc Trop Med Hyg 49:28–32

    Article  CAS  Google Scholar 

  13. Tsetsarkin KA, Weaver SC (2011) Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence. PLoS Pathog 7:e1002412

    Article  CAS  Google Scholar 

  14. Tun MM, Thant KZ, Inoue S, Nabeshima T, Aoki K, Kyaw AK, Myint T, Tar T, Maung KT, Hayasaka D, Morita K (2014) Detection of east/central/south African genotype of chikungunya virus in Myanmar, 2010. Emerg Infect Dis 20:1378–1381

    Article  CAS  Google Scholar 

  15. Wu D, Wu J, Zhang Q, Zhong H, Ke C, Deng X, Guan D, Li H, Zhang Y, Zhou H, He J, Li L, Yang X (2012) Chikungunya outbreak in Guangdong Province, China, 2010. Emerg Infect Dis 18:493–495

    Article  Google Scholar 

Download references

Acknowledgements

The study was fully supported by grants from the National Key Research and Development Program for the 13th Five-Year Plan from the Ministry of Science and Technology, China (2017YFD0501800), the Science and Technology Programs of Military, China (15QNP035), and a General Financial Grant (2015M582907) from the China Postdoctoral Science Foundation. We thank Katie Oakley, PhD, from Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Author information

Author notes

  1. XiaoXiong Yin, Ting-Song Hu, HaiLin Zhang contributed equally to this article.

Authors and Affiliations

  1. Ruili Center for Disease Control and Prevention, Ruili, Yunnan, People’s Republic of China

    XiaoXiong Yin, YongHua Liu, Ping Li, ZhaoLan Yang & SiYu Chen

  2. Center for Disease Control and Prevention of Southern Theater Command, Kunming, Yunnan Province, 650118, People’s Republic of China

    Ting-Song Hu, ZhiJian Zhou, LeBin Liu, YiYin Wang, Jing Yu & Fu-Qiang Zhang

  3. Yunnan Institute of Endemic Diseases Control and Prevention, Dali, Yunnan, People’s Republic of China

    HaiLin Zhang

Authors
  1. XiaoXiong Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ting-Song Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. HaiLin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. YongHua Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. ZhiJian Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. LeBin Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ping Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. YiYin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. ZhaoLan Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jing Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. SiYu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Fu-Qiang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ting-Song Hu or Fu-Qiang Zhang.

Ethics declarations

Conflict of interests

The authors declare they have no competing interests.

Additional information

Handling Editor: Patricia Aguilar.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (XLSX 12 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yin, X., Hu, TS., Zhang, H. et al. Emergent chikungunya fever and vertical transmission in Yunnan Province, China, 2019. Arch Virol 166, 1455–1462 (2021). https://doi.org/10.1007/s00705-021-05005-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-021-05005-1

Search

Navigation