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Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity

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Summary.

The deduced amino acid sequences of segment A and B of two very virulent Infectious bursal disease virus (vvIBDV) isolates, UPM94/273 and UPM97/61 were compared with 25 other IBDV strains. Twenty amino acid residues (8 in VP1, 5 in VP2, 2 in VP3, 4 in VP4, 1 in VP5) that were common to vvIBDV strains were detected. However, UPM94/273 is an exceptional vvIBDV with usual amino acid substitutions. The differences in the divergence of segment A and B indicated that the vvIBDV strains may have been derived from genetic reassortment of a single ancestral virus or both segments have different ability to undergo genetic variation due to their different functional constraints.

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Authors and Affiliations

  1. Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia, , , , , , MY

    L. L. Kong, A. R. Omar, M. Hair-Bejo & I. Aini

  2. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia, , , , , , MY

    H. F. Seow

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  1. L. L. Kong
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  2. A. R. Omar
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  3. M. Hair-Bejo
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  4. I. Aini
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  5. H. F. Seow
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Kong, L., Omar, A., Hair-Bejo, M. et al. Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity. Arch Virol 149, 425–434 (2004). https://doi.org/10.1007/s00705-003-0206-6

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  • DOI: https://doi.org/10.1007/s00705-003-0206-6

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