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Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans

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Summary.

To investigate the possible involvement of the butyrylcholinesterase (BCHE) K variant and transferrin (TF) C2 variant in the manifestation of Alzheimer's disease (AD), we analyzed the BCHE, TF and apolipoprotein E (APOE) genotypes of 164 sporadic AD patients and 239 normal elderly controls.

The frequencies of the BCHE K and TF C2 did not differ between the AD patients and controls (P > 0.1). The occurrence of the APOE ε4 did not influence the distribution of the BCHE K and TF C2 variants (P > 0.1). No linkage disequilibrium between the BCHE K and TF C2 was observed either in both the AD patients and controls (P > 0.1).

In conclusion, neither the BCHE K nor the TF C2 confers a risk for AD.

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Authors and Affiliations

  1. Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin,, , , , , , KR

    K. W. Kim & D. Y. Lee

  2. Neuroscience Research Institute of Medical Research Center, Seoul National University, and Clinical Research Institute of Seoul National University Hospital, Seoul,, , , , , , KR

    J. C. Youn, J. Y. Youn & J. I. Woo

  3. Research Institute of Aging and Physical Culture of Medical Research Center, Seoul National University, College of Medicine, Seoul,, , , , ,

    J. H. Jhoo

  4. Department of Neuropsychiatry, Kangwon National University College of Medicine, Chunchon,, , , , , , KR

    J. H. Lee

  5. Department of Neuropsychiatry, Seoul National Mental Hospital, Seoul, and, , , , , , KR

    K. U. Lee

Authors
  1. K. W. Kim
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  2. J. H. Jhoo
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  3. J. H. Lee
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  4. K. U. Lee
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  5. D. Y. Lee
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  6. J. C. Youn
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  7. J. Y. Youn
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  8. J. I. Woo
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Additional information

Received February 9, 2001; accepted June 8, 2001

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Kim, K., Jhoo, J., Lee, J. et al. Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans. J Neural Transm 108, 1159–1166 (2001). https://doi.org/10.1007/s007020170005

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  • DOI: https://doi.org/10.1007/s007020170005

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