Abstract
Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the “intruder–resident” paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
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Acknowledgments
This work was sponsored by grants from MACKPESQUISA and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Adelisandra Silva Santos Castelhano is a fellow of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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Castelhano, A.S.S., Scorza, F.A., Teixeira, M.C.T.V. et al. Social play impairment following status epilepticus during early development. J Neural Transm 117, 1155–1160 (2010). https://doi.org/10.1007/s00702-010-0460-1
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DOI: https://doi.org/10.1007/s00702-010-0460-1