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Glutamatergic ionotropic blockade within accumbens disrupts working memory and might alter the endocytic machinery in rat accumbens and prefrontal cortex

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Summary

Effects of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA glutamatergic receptors on performance in the hole board test was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats, divided into 5 groups, received either 1 µl injections of saline, (±) 2-amino-7-phosphonoheptanoic acid (AP-7) (0.5 or 1 µg) or 2,3-dioxo-6-nitro-1,2,3,4,tetrahydrobenzo-(f)quinoxaline-7-sulphonamide disodium (NBQX, 0.5 or 1 µg) 10 min before testing. An increase by AP-7 was observed in ambulatory movements (0.5 µg; p < 0.05), non-ambulatory movements and number of movements (1 µg; p < 0.05); sniffing and total exploration (1 µg; p < 0.01). When holes were considered in order from the first to the fifth by the number of explorations, the most visited holes (first and second) of the AP-7 group were significantly higher than the corresponding holes of saline group (p < 0.05 for 0.5 µg and p < 0.001 for 1 µg). When the second hole was compared with the first of his group, a difference was only observed in the AP-7 1 µg group (p < 0.001). Increasing differences between the other holes and the first were observed by drug treatment. At molecular level, it was observed that AP-7 induced an increase of the coat protein AP-2 expression in Acc, but not AP-180 neither the synaptic protein synaptophysin. The increase of AP-2 was also observed in the medial prefrontal cortex by the action of AP-7 but not NBQX. We conclude that NMDA glutamatergic blockade might induce an activation of the endocytic machinery into the Acc, leading to stereotypies and perseverations, lacking cortical intentional direction.

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References

  • MJ Acerbo PA Gargiulo I Krug JD Delius (2002) ArticleTitleBehavioural consequences of nucleus accumbens dopaminergic stimulation and glutamatergic blocking in pigeons Behav Brain Res 136 IssueID1 171–177 Occurrence Handle12385802 Occurrence Handle10.1016/S0166-4328(02)00109-2 Occurrence Handle1:CAS:528:DC%2BD38XnvVOltLc%3D

    Article  PubMed  CAS  Google Scholar 

  • RL Albin RL Makowiec ZR Hollingsworth LS Dure SuffixIV JB Penney AB Young (1991) ArticleTitleExcitatory amino acid binding sites in the basal ganglia of the rat: a quantitative autoradiographic study Neuroscience 46 35–48 Occurrence Handle10.1016/0306-4522(92)90006-N

    Article  Google Scholar 

  • JM Aultman B Moghaddam (2001) ArticleTitleDistinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinical relevant task Psychopharmacology 153 353–364 Occurrence Handle11271408 Occurrence Handle10.1007/s002130000590 Occurrence Handle1:CAS:528:DC%2BD3MXhtlWltb4%3D

    Article  PubMed  CAS  Google Scholar 

  • AE Baldwin K Sadeghian MR Holahan AE Kelley (2002) ArticleTitleAppetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbens Neurobiol Learn Mem 77 IssueID1 44–62 Occurrence Handle11749085 Occurrence Handle10.1006/nlme.2000.4002 Occurrence Handle1:CAS:528:DC%2BD3MXptFOkt78%3D

    Article  PubMed  CAS  Google Scholar 

  • SP Baron JMJ Moersbaecher (1996) ArticleTitleDisruption of learning by excitatory amino acid receptor antagonists Behav Pharmacol 7 573–584 Occurrence Handle11224454 Occurrence Handle1:CAS:528:DyaK2sXmsF2qtg%3D%3D

    PubMed  CAS  Google Scholar 

  • EC Beattie RC Carroll W Morishita H Yasuda M von Zastrow RC Malenka (2000) ArticleTitleRegulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD Nat Neurosci 3 IssueID12 1291–1300 Occurrence Handle11100150 Occurrence Handle10.1038/81823 Occurrence Handle1:CAS:528:DC%2BD3cXosVGgsbs%3D

    Article  PubMed  CAS  Google Scholar 

  • A Breier AK Malhotra DA Pinals NI Weisenfeld D Pickar (1997) ArticleTitleAssociation of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers Am J Psychiatry 154 IssueID6 805–811 Occurrence Handle9167508 Occurrence Handle1:STN:280:ByiA3M%2FjsVU%3D

    PubMed  CAS  Google Scholar 

  • A Carlsson LO Hansson N Waters ML Carlsson (1998) ArticleTitleA glutamatergic deficiency model of schizophren Br J Psychiatry 173 IssueIDSuppl 37 2–6

    Google Scholar 

  • A Carlsson N Waters S Waters ML Carlsson (2000) ArticleTitleNetworks interactions in schizophrenia-therapeutic implications Brain Res Rev 31 342–349 Occurrence Handle10719161 Occurrence Handle10.1016/S0165-0173(99)00050-8 Occurrence Handle1:STN:280:DC%2BD3c7osFGjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Carlsson A Carlsson (1990) ArticleTitleSchizophrenia: a subcortical neurotransmitter imbalance syndrome? Schizophrenia Bull 16 425–432 Occurrence Handle1:STN:280:By6C2c3nsFQ%3D

    CAS  Google Scholar 

  • G Chen JT Kittler SJ Moss Z Yan (2006) ArticleTitleDopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens J Neurosci 26 IssueID9 2513–2521 Occurrence Handle16510729 Occurrence Handle10.1523/JNEUROSCI.4712-05.2006 Occurrence Handle1:CAS:528:DC%2BD28XislKqsrw%3D

    Article  PubMed  CAS  Google Scholar 

  • MA Cousin PJ Robinson (2001) ArticleTitleThe depohosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis Trends Neurosci 24 659–665 Occurrence Handle11672811 Occurrence Handle10.1016/S0166-2236(00)01930-5 Occurrence Handle1:CAS:528:DC%2BD3MXnslels7o%3D

    Article  PubMed  CAS  Google Scholar 

  • RA Crowther JT Finch BM Pearse (1976) ArticleTitleOn the structure of coated vesicles J Mol Biol 103 785–798 Occurrence Handle940164 Occurrence Handle10.1016/0022-2836(76)90209-6 Occurrence Handle1:CAS:528:DyaE28Xkt12kurg%3D

    Article  PubMed  CAS  Google Scholar 

  • S Del Vecchio PA Gargiulo (1992) ArticleTitleVisual and motor function in schizophrenic patients Acta Psiquiat Psicol Am Lat 38 317–322 Occurrence Handle1:STN:280:ByuD2s%2FktFc%3D

    CAS  Google Scholar 

  • P Di Ciano RN Cardinal RA Cowell SJ Little BJ Everitt (2001) ArticleTitleDifferential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior J Neurosci 21 IssueID23 9471–9477 Occurrence Handle11717381 Occurrence Handle1:CAS:528:DC%2BD3MXosl2gtr8%3D

    PubMed  CAS  Google Scholar 

  • MF Egan TE Goldberg BS Kolachana JH Callicott CM Mazzanti RE Straub D Goldman DR Weinberger (2001) ArticleTitleEffect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia Proc Natl Acad Sci USA 98 IssueID12 6917–6922 Occurrence Handle11381111 Occurrence Handle10.1073/pnas.111134598 Occurrence Handle1:CAS:528:DC%2BD3MXksVOrsL4%3D

    Article  PubMed  CAS  Google Scholar 

  • MD Ehlers (2000) ArticleTitleReinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting Neuron 28 IssueID2 511–525 Occurrence Handle11144360 Occurrence Handle10.1016/S0896-6273(00)00129-X Occurrence Handle1:CAS:528:DC%2BD3cXoslaisbo%3D

    Article  PubMed  CAS  Google Scholar 

  • G Gal D Joel O Gusak J Feldon I Weiner (1997) ArticleTitleThe effects of electrolytic lesion to the shell subterritory of the nucleus accumbens on delayed non-matching-to-sample and four-arm baited eight-arm radial-maze tasks Behav Neurosci 111 92–103 Occurrence Handle9109627 Occurrence Handle10.1037/0735-7044.111.1.92 Occurrence Handle1:STN:280:ByiB28zntFY%3D

    Article  PubMed  CAS  Google Scholar 

  • PA Gargiulo (1996) ArticleTitleThyrotropin releasing hormone injected into the nucleus accumbens septi selectively increases face grooming in rats Braz J Med Biol Res 29 805–810 Occurrence Handle9070394 Occurrence Handle1:CAS:528:DyaK28XksFeksLc%3D

    PubMed  CAS  Google Scholar 

  • PA Gargiulo (2001) ArticleTitleExperimental approaches to delusional perception Alcmeon Rev Arg Neuropsiqu 37 18–30

    Google Scholar 

  • PA Gargiulo (2003) ArticleTitleExperimental approaches to perceptual dysfunction in schizophrenia Rev Neurol 37 IssueID6 545–551 Occurrence Handle14533075 Occurrence Handle1:STN:280:DC%2BD3svntVKlsg%3D%3D

    PubMed  CAS  Google Scholar 

  • PA Gargiulo M Siemann J Delius (1998) ArticleTitleVisual discrimination in pigeons impaired by glutamatergic blockade of nucleus accumbens Physiol Behav 63 705–709 Occurrence Handle9523919 Occurrence Handle10.1016/S0031-9384(97)00516-7 Occurrence Handle1:CAS:528:DyaK1cXhs1Snt74%3D

    Article  PubMed  CAS  Google Scholar 

  • PA Gargiulo AI Landa de Gargiulo (2004) ArticleTitlePerception and psychoses: the role of glutamatergic transmission within the nucleus accumbens septi Behav Brain Sci 27 IssueID6 792–793 Occurrence Handle10.1017/S0140525X04270182

    Article  Google Scholar 

  • PA Gargiulo MJ Acerbo I Krug JD Delius (2005) ArticleTitleCognitive effects of dopaminergic and glutamatergic blockade in nucleus accumbens in pigeons Pharmacol Biochem Behav 81 IssueID4 732–739 Occurrence Handle15979133 Occurrence Handle10.1016/j.pbb.2005.05.009 Occurrence Handle1:CAS:528:DC%2BD2MXos1WrtL4%3D

    Article  PubMed  CAS  Google Scholar 

  • Goldman-Rakic PS (1995) Architecture of the prefrontal cortex. In: Grafman J, Holyoak KJ, Boller F (eds) Structure and functions of the human prefrontal cortex. Ann NY Acad Sci 769: 71–83

  • AA Grace (2000) ArticleTitleGating of information flow within the limbic system and the pathophysiology of schizophrenia Brain Res Rev 31 IssueID2–3 330–341 Occurrence Handle10719160 Occurrence Handle10.1016/S0165-0173(99)00049-1 Occurrence Handle1:STN:280:DC%2BD3c7osFGjtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • C Holden (2003a) ArticleTitleDeconstructing schizophrenia Science 299 333–335 Occurrence Handle10.1126/science.299.5605.333 Occurrence Handle1:CAS:528:DC%2BD3sXhtlCisbw%3D

    Article  CAS  Google Scholar 

  • C Holden (2003b) ArticleTitleExcited by glutamate Science 300 1866–1868 Occurrence Handle10.1126/science.300.5627.1866 Occurrence Handle1:CAS:528:DC%2BD3sXkvVantLY%3D

    Article  CAS  Google Scholar 

  • M Jessa M Nazar A Plaznik (1996) ArticleTitleEffect of intra-accumbens blockade of NMDA receptors in two models of anxiety, in rats Neurosci Res Commun 19 19–25 Occurrence Handle10.1002/(SICI)1520-6769(199607)19:1<19::AID-NRC159>3.0.CO;2-M Occurrence Handle1:CAS:528:DyaK28Xlt1Ghs70%3D

    Article  CAS  Google Scholar 

  • C Kalthoff J Alves C Urbanke R Knorr EJ Ungewickell (2002) ArticleTitleUnusual structural organization of the endocytic proteins AP-180 and epsin 1 J Biol Chem 277 8209–8216 Occurrence Handle11756460 Occurrence Handle10.1074/jbc.M111587200 Occurrence Handle1:CAS:528:DC%2BD38XitFymtrw%3D

    Article  PubMed  CAS  Google Scholar 

  • S Keller JD Delius (2001) ArticleTitleDiscriminative learning occasioned by the administration of a dopamine antagonist Psychopharmacology 157 320–323 Occurrence Handle11605089 Occurrence Handle10.1007/s002130100847 Occurrence Handle1:CAS:528:DC%2BD3MXosVKhsLo%3D

    Article  PubMed  CAS  Google Scholar 

  • S Keri I Szendi O Kelemen G Benedek Z Janka (2001) ArticleTitleRemitted schizophrenia-spectrum patients with spared working memory show information processing abnormalities Eur Arch Psych Clin Neurosci 251 IssueID2 60–65 Occurrence Handle10.1007/s004060170054 Occurrence Handle1:STN:280:DC%2BD38%2FhtlChsA%3D%3D

    Article  CAS  Google Scholar 

  • T Kirchhausen (1999) ArticleTitleAdaptors for clathrin-mediated traffic Annu Rev Cell Dev Biol 15 705–732 Occurrence Handle10611976 Occurrence Handle10.1146/annurev.cellbio.15.1.705 Occurrence Handle1:CAS:528:DC%2BD3cXhtVSnu7k%3D

    Article  PubMed  CAS  Google Scholar 

  • UK Laemmli (1977) ArticleTitleCleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 680–685 Occurrence Handle10.1038/227680a0

    Article  Google Scholar 

  • M Laruelle A Abi-Dargham CH van Dyck R Gil CD D’Souza J Erdos E McCance W Rosenblatt C Fingado SS Zoghbi RM Baldwin LJP Seiby JH Krystal DS Charney RB Innis (1996) ArticleTitleSingle photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects Proc Natl Acad Sci USA 93 IssueID17 9235–9240 Occurrence Handle8799184 Occurrence Handle10.1073/pnas.93.17.9235 Occurrence Handle1:CAS:528:DyaK28Xlt1CntL8%3D

    Article  PubMed  CAS  Google Scholar 

  • M Le Moal (1995) Mesocorticolimbic dopaminergic neurons. Functional and regulatory roles FE Bloom DJ Kupfer (Eds) Psychopharmacology: the fourth generation of progress Raven Press New York 283–294

    Google Scholar 

  • B Levant (1997) ArticleTitleThe D3 dopamine receptor: neurobiology and potential clinical relevance Pharmacol Rev 49 231–252 Occurrence Handle9311022 Occurrence Handle1:CAS:528:DyaK2sXmtl2hsb4%3D

    PubMed  CAS  Google Scholar 

  • JW Lin W Ju K Foster SH Lee G Ahmadian M Wyszyski YT Wang M Sheng (2000) ArticleTitleDistinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization Nat Neurosci 3 IssueID2 1282–1290 Occurrence Handle11100149 Occurrence Handle10.1038/81814 Occurrence Handle1:CAS:528:DC%2BD3cXosVGgsbo%3D

    Article  PubMed  CAS  Google Scholar 

  • O Lowry A Rosembroough R Farr R Randall (1951) ArticleTitleProtein measurement with the Folin phenol reagent J Biol Chem 193 265–275 Occurrence Handle14907713 Occurrence Handle1:CAS:528:DyaG38XhsVyrsw%3D%3D

    PubMed  CAS  Google Scholar 

  • M Lyon TW Robbins (1975) The action of central nervous system stimulant drugs: a general theory concerning amphetamine effects W Essman L Valzelli (Eds) Current developments in psychopharmacology NumberInSeries2 Spectrum Publications New York 79–163

    Google Scholar 

  • JJ Manfredi WL Bazari (1987) ArticleTitlePurification and characterization or two distinct complexes of assembly polypeptides from calf brain coated vesicles that differ in their polypeptide composition and kinase activities J Biol Chem 262 12182–12188 Occurrence Handle2887566 Occurrence Handle1:CAS:528:DyaL2sXlvFers7Y%3D

    PubMed  CAS  Google Scholar 

  • A Manzur MA Sosa AM Seltzer (2001) ArticleTitleTransient increase in Rab 3 and Synaptobrevin immunoreactivity after mild hypoxia in neonatal rats Cell Mol Neurobiol 21 IssueID1 39–52 Occurrence Handle11440197 Occurrence Handle10.1023/A:1007169228329 Occurrence Handle1:STN:280:DC%2BD38%2FhvVyjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Martin G Gonzalez-Calero A Cubero (1991) ArticleTitleCharacterization of L- [3H]glutamate binding sites in bovine brain coated vesicles Eur J Pharmacol 207 IssueID3 215–224 Occurrence Handle1680061 Occurrence Handle10.1016/0922-4106(91)90033-E Occurrence Handle1:CAS:528:DyaK3MXlsFegtLg%3D

    Article  PubMed  CAS  Google Scholar 

  • G Martínez C Ropero A Funes E Flores AI Landa PA Gargiulo (2002a) ArticleTitleAP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task Physiol Behav 76 IssueID2 205–212 Occurrence Handle10.1016/S0031-9384(02)00696-0

    Article  Google Scholar 

  • G Martínez C Ropero A Funes E Flores C Blotta AI Landa PA Gargiulo (2002b) ArticleTitleEffects of NMDA and non-NMDA blockade in the nucleus accumbens on the plus maze test Physiol Behav 76 IssueID2 219–224 Occurrence Handle10.1016/S0031-9384(02)00704-7

    Article  Google Scholar 

  • DW Miller ED Abercrombie (1996) ArticleTitleEffects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats Brain Res Bull 40 IssueID1 57–62 Occurrence Handle8722754 Occurrence Handle10.1016/0361-9230(95)02144-2 Occurrence Handle1:CAS:528:DyaK28XjtlegsrY%3D

    Article  PubMed  CAS  Google Scholar 

  • H Moore AR West AA Grace (1999) ArticleTitleThe regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia Biol Psychiatry 46 40–55 Occurrence Handle10394473 Occurrence Handle10.1016/S0006-3223(99)00078-5 Occurrence Handle1:CAS:528:DyaK1MXksVaqtbc%3D

    Article  PubMed  CAS  Google Scholar 

  • SM Nicola DJ Surmeier RC Malenka (2000) ArticleTitleDopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens Annu Rev Neurosci 23 185–215 Occurrence Handle10845063 Occurrence Handle10.1146/annurev.neuro.23.1.185 Occurrence Handle1:CAS:528:DC%2BD3cXjs1Gmsr8%3D

    Article  PubMed  CAS  Google Scholar 

  • Y Nong YQ Huang W Ju LV Kalia G Ahmadian YT Wang MW Salter (2003) ArticleTitleGlycine binding primes NMDA receptor internalization Nature 422 IssueID6929 302–307 Occurrence Handle12646920 Occurrence Handle10.1038/nature01497 Occurrence Handle1:CAS:528:DC%2BD3sXitFKmu7g%3D

    Article  PubMed  CAS  Google Scholar 

  • RD Oades (1981a) ArticleTitleImpairments of search behaviour in rats after haloperidol treatment, hipocampal or neocortical damage suggest a mesocoricolimbic role in cognition Biol Psychol 12 77–85 Occurrence Handle10.1016/0301-0511(81)90021-1 Occurrence Handle1:STN:280:Bi2D2cnpvVI%3D

    Article  CAS  Google Scholar 

  • RD Oades (1981b) ArticleTitleDopaminergic agonistic and antagonistic drugs in the ventral tegmentum of rats inhibit and facilitate changes of food search behaviour Neurosci Lett 27 75–80 Occurrence Handle10.1016/0304-3940(81)90208-1 Occurrence Handle1:CAS:528:DyaL38Xks1Wksg%3D%3D

    Article  CAS  Google Scholar 

  • RD Oades (1982) ArticleTitleSearch strategies on a hole-board are impaired in rats with ventral tegmental damage: animal model for tests of thought disorder Biol Psychiatry 17 243–258 Occurrence Handle7074182 Occurrence Handle1:STN:280:Bi2C1czhtl0%3D

    PubMed  CAS  Google Scholar 

  • RD Oades RL Isaacson (1978) ArticleTitleThe development of food search behavior by rats: the effects of hippocampal damage and haloperidol Behav Biol 24 327–337 Occurrence Handle743067 Occurrence Handle10.1016/S0091-6773(79)90184-6 Occurrence Handle1:STN:280:CSaC38zntl0%3D

    Article  PubMed  CAS  Google Scholar 

  • LJ Pellegrino AS Pellegrino AJ Cushman (1979) A stereotaxic atlas of the rat brain Plenum Press New York

    Google Scholar 

  • CMA Pennartz HJ Groenewegen F Lopes da Silva (1994) ArticleTitleThe nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data Prog Neurobiol 42 719–761 Occurrence Handle7938546 Occurrence Handle10.1016/0301-0082(94)90025-6 Occurrence Handle1:STN:280:ByqD38vntlc%3D

    Article  PubMed  CAS  Google Scholar 

  • ER Peters JA Nunn AD Pickering DR Hemsley (2002) ArticleTitlePerceptual organization deficits in psychotic patients Psychiatry Res 110 IssueID2 125–135 Occurrence Handle12057825 Occurrence Handle10.1016/S0165-1781(02)00096-3

    Article  PubMed  Google Scholar 

  • RS Petralia YX Wang RJ Wenthold (2003) ArticleTitleInternalization at glutamatergic synapses during development Eur J Neurosci 18 IssueID12 3207–3217 Occurrence Handle14686895 Occurrence Handle10.1111/j.1460-9568.2003.03074.x

    Article  PubMed  Google Scholar 

  • A Plaznik W Palejko M Nazar M Jessa (1994) ArticleTitleEffects of antagonists at the NMDA receptor complex in two models of anxiety Eur Neuropsychopharmacol 4 503–512 Occurrence Handle7894261 Occurrence Handle10.1016/0924-977X(94)90299-2 Occurrence Handle1:CAS:528:DyaK2MXitlWqt7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • DA Richards C Watimosin WJ Betz (2000) ArticleTitleTwo endocytic recycling routes selectively fill two vesicle pools in frog motor nerve terminals Neuron 27 551–559 Occurrence Handle11055437 Occurrence Handle10.1016/S0896-6273(00)00065-9 Occurrence Handle1:CAS:528:DC%2BD3cXnt12ntL4%3D

    Article  PubMed  CAS  Google Scholar 

  • NM Richtand SC Woods SP Berger SM Strakowski (2001) ArticleTitleD3 dopamine receptor, behavioral sensitization, and psychosis Neurosci Biobehav Rev 25 427–443 Occurrence Handle11566480 Occurrence Handle10.1016/S0149-7634(01)00023-9 Occurrence Handle1:CAS:528:DC%2BD3MXmvVyhsLo%3D

    Article  PubMed  CAS  Google Scholar 

  • TW Robbins (1991) Cognitive deficits in schizophrenia and Parkinson’s disease: neural basis and the role of dopamine P Willner J Scheel Kruger (Eds) The mesolimbic dopamine system: from motivation to action Wiley Chichester 497–528

    Google Scholar 

  • P Roullet F Sargolini A Oliverio A Mele (2001) ArticleTitleNMDA and AMPA antagonist infusions into the ventral striatum impair different steps of spatial information processing in a nonassociative task in mice J Neurosci 21 IssueID6 2143–2149 Occurrence Handle11245698 Occurrence Handle1:CAS:528:DC%2BD3MXjslClt7Y%3D

    PubMed  CAS  Google Scholar 

  • SL Schmid (1997) ArticleTitleClathrin-coated vesicle formation and protein sorting: an integrated process Annu Rev Biochem 66 511–548 Occurrence Handle9242916 Occurrence Handle10.1146/annurev.biochem.66.1.511 Occurrence Handle1:CAS:528:DyaK2sXktFOnu74%3D

    Article  PubMed  CAS  Google Scholar 

  • WJ Schmidt (1998) ArticleTitleDopamine-glutamate interactions in the basal ganglia Amino Acids 14 5–10 Occurrence Handle9871434 Occurrence Handle10.1007/BF01345235 Occurrence Handle1:CAS:528:DyaK1cXjtlKjsbw%3D

    Article  PubMed  CAS  Google Scholar 

  • WJ Schmidt BD Kretschmer (1997) ArticleTitleBehavioural pharmacology of glutamate receptors in the basal ganglia Neurosci Biobehav Rev 21 IssueID4 381–392 Occurrence Handle9195596 Occurrence Handle10.1016/S0149-7634(96)00044-9 Occurrence Handle1:CAS:528:DyaK2sXktl2iu7o%3D

    Article  PubMed  CAS  Google Scholar 

  • S Schroder E Ungewickel (1991) ArticleTitleSubunit interaction and function of clathrin coated vesicle adaptors from the Golgi and the plasma membrane J Biol Chem 266 7910–7918 Occurrence Handle1902231 Occurrence Handle1:STN:280:By6B3M%2Fjt1Q%3D

    PubMed  CAS  Google Scholar 

  • VI Slevnev P De Camilli (2000) ArticleTitleAccessory factors in clathrin-dependent synaptic vesicle endocytosis Nat Rev Neurosci 1 161–172 Occurrence Handle10.1038/35044540

    Article  Google Scholar 

  • SL Smith-Roe AE Kelley (2000) ArticleTitleCoincident activation of NMDA and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning J Neurosci 20 IssueID20 7737–7742 Occurrence Handle11027236 Occurrence Handle1:CAS:528:DC%2BD3cXns1eitr4%3D

    PubMed  CAS  Google Scholar 

  • EM Snyder BD Philpot KM Huber X Dong JR Fallon MF Bear (2001) ArticleTitleInternalization of ionotropic glutamate receptors in response to mGluR activation Nat Neurosci 4 IssueID11 1079–1085 Occurrence Handle11687813 Occurrence Handle10.1038/nn746 Occurrence Handle1:CAS:528:DC%2BD3MXot1Wqt7c%3D

    Article  PubMed  CAS  Google Scholar 

  • W Sun N Ginovart F Ko P Seeman S Kapur (2003) ArticleTitleIn vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: differential findings with [3H] raclopride versus [3H] spiperone Mol Pharmacol 63 IssueID2 456–462 Occurrence Handle12527818 Occurrence Handle10.1124/mol.63.2.456 Occurrence Handle1:CAS:528:DC%2BD3sXnvV2nsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • K Taghzouti A Louilot JP Herman M Le Moal H Simon (1985) ArticleTitleAlternation behavior, spatial discrimination, and reversal disturbances in the nucleus accumbens of the rat Behav Neural Biol 44 354–363 Occurrence Handle3936470 Occurrence Handle10.1016/S0163-1047(85)90640-5 Occurrence Handle1:CAS:528:DyaL28Xks1ajtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • F Tebar T Sorkina A Sorkin M Ericsson T Kirchhausen (1996) ArticleTitleEps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits J Biol Chem 271 28727–28730 Occurrence Handle8910509 Occurrence Handle10.1074/jbc.271.46.28727 Occurrence Handle1:CAS:528:DyaK28XntFKntL8%3D

    Article  PubMed  CAS  Google Scholar 

  • TM Tzschentke WJ Schmidt (2000) ArticleTitleFunctional relationship among medial prefrontal cortex, nucleus accumbens, and ventral tegmental area in locomotion and reward Crit Rev Neurobiol 14 IssueID2 131–142 Occurrence Handle11513242 Occurrence Handle1:CAS:528:DC%2BD3MXmsF2gurw%3D

    PubMed  CAS  Google Scholar 

  • FJ van der Staay (1999) ArticleTitleSpatial working and reference memory of Brown Norway and WAG rats in the holeboard task Neurobiol Learn Mem 71 113–125 Occurrence Handle9889077 Occurrence Handle10.1006/nlme.1998.3860 Occurrence Handle1:STN:280:DyaK1M7gvVahsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • FJ van der Staay J van Nies WGM Raaijmakers (1990a) ArticleTitleThe effects of aging in rats on working and reference memory performance in a spatial holeboard discrimination task Behav Neural Biol 53 356–370 Occurrence Handle10.1016/0163-1047(90)90226-V Occurrence Handle1:STN:280:By%2BB2svmtlY%3D

    Article  CAS  Google Scholar 

  • FJ van der Staay B Krechting A Blokland WGM Raaijmakers (1990b) ArticleTitleThe cone field: a spatial discrimination task for the automatic and simultaneous assessment of working and reference memory in rats J Neurosci Methods 31 13–22 Occurrence Handle10.1016/0165-0270(90)90004-Y Occurrence Handle1:STN:280:By%2BC2szjslA%3D

    Article  CAS  Google Scholar 

  • FX Vollenweider KL Leenders C Scharfetter A Antonini P Maguire J Missimer J Angst (1997) ArticleTitleMetabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) Eur Neuropsychopharmacol 7 IssueID1 9–24 Occurrence Handle9088881 Occurrence Handle10.1016/S0924-977X(96)00039-9 Occurrence Handle1:CAS:528:DyaK2sXhtlyisrw%3D

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratorio de Neurociencias y Psicología Experimental, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    G. Baiardi, G. Martínez, A. I. Landa & P. A. Gargiulo

  2. Instituto de Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    A. M. Ruiz, A. Beling, J. Borgonovo & M. A. Sosa

Authors
  1. G. Baiardi
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  2. A. M. Ruiz
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  3. A. Beling
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  4. J. Borgonovo
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  5. G. Martínez
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  6. A. I. Landa
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  7. M. A. Sosa
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  8. P. A. Gargiulo
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Authors contributed equally

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Baiardi, G., Ruiz, A., Beling, A. et al. Glutamatergic ionotropic blockade within accumbens disrupts working memory and might alter the endocytic machinery in rat accumbens and prefrontal cortex. J Neural Transm 114, 1519–1528 (2007). https://doi.org/10.1007/s00702-007-0776-7

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  • DOI: https://doi.org/10.1007/s00702-007-0776-7