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Conductive and self-healing hydrogel for flexible electrochemiluminescence sensor

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Abstract

A flexible electrochemiluminescence (ECL) hydrogel sensor exhibiting good self-healing was constructed. A transparent self-healing oxidized sodium alginate/hydrazide polyethylene glycol (OSA/PEG-DH) hydrogel was prepared by crosslinking dynamic covalent acylhydrazone bond. The introduction of 4-amino-DL-phenylalanine, a catalyst with good biocompatibility, allows rapid gelation and self-healing of hydrogel under mild conditions. Using the hydrogel as the sensing substrate, the ionic liquid (IL) 2-hydroxy-N,N,N-trimethylethanaminium chloride and the luminescent reagent N-(aminobutyl)-N-(ethylisoluminol) (ABEI) were simultaneously immobilized in the OSA/PEG-DH hydrogel to obtain the ABEI/IL/OSA/PEG-DH hydrogel. The ABEI/IL/OSA/PEG-DH hydrogel can be directly used as a semi-solid electrolyte for constructing a flexible ECL hydrogel sensor for the detection of H2O2, which acted as a coreactant of ABEI. The prepared flexible ECL sensor showed good self-healing performance, can restore ECL signal intensity within 20 min after physical damage, and showed high accuracy in the analysis of complex serum samples. This research shed new light on the development of flexible ECL sensor for bioanalytical applications.

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All data generated or analysed during this study are included in this published article (and its supplementary information files).

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (201874005).

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Authors and Affiliations

  1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China

    Xuejiao Liu, Yang Bai, Xiaoxiao Zhao, Jun Chen, Xu Chen & Wensheng Yang

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  1. Xuejiao Liu
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  2. Yang Bai
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  3. Xiaoxiao Zhao
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  4. Jun Chen
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  5. Xu Chen
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Liu, X., Bai, Y., Zhao, X. et al. Conductive and self-healing hydrogel for flexible electrochemiluminescence sensor. Microchim Acta 190, 123 (2023). https://doi.org/10.1007/s00604-023-05706-1

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