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Ultrasound supported synthesis of tantalum carbide integrated functionalized carbon composite for the voltammetric determination of the antibacterial drug nitrofurantoin in pharmaceutical samples

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Abstract

The synthesis and fabrication of oval-shaped tantalum carbide (Ta-C) integrated functionalized-multiwalled carbon nanotube (Ta-C/f-MWCNT) as an electrocatalyst for the electrochemical determination of nitrofurantoin (NFT) is described. The Ta-C/f-MWCNT composite was prepared using the soft-template method followed by the ultrasonication process. The as-prepared Ta-C/f-MWCNT composite was characterized using powder X-ray diffraction (XRD), Raman spectroscopy, field emission scanning electron microscopy (FESEM), scanning transmission electron microscopy (STEM), and X-ray photoelectron spectroscopy (XPS) analysis. The electrochemical properties of Ta-C/f-MWCNT were investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and linear sweep voltammetry (LSV). The Ta-C/f-MWCNT-modified glassy carbon electrode (Ta-C/f-MWCNT/GCE) was successfully utilized as an active electrocatalyst for the detection of NFT in the presence of 0.384 mM NFT containing 0.05 M phosphate buffer (pH 7) at a scan rate of 50 mV/s. The Ta-C/f-MWCNT/GCE exhibited a wide linear response range (0.04–1047 μM) and a low detection limit (0.0011 μM). Further, the Ta-C/f-MWCNT/GCE showed appreciable results for repeatability, reproducibility, and long-term cyclic stability towards NFT sensing. The Ta-C/f-MWCNT/GCE was applied to real sample analysis such as a commercial tablet and human urine samples. The Ta-C/f-MWCNT/GCE exhibited good recovery values for the tablet (105 to 115%) and urine (101–107%) samples. The above electrochemical results suggest that the Ta-C/f-MWCNT is a promising electrocatalyst for the electrochemical sensing of NFT drug.

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Funding

Financial support of this work by the Ministry of Science and Technology, Taiwan (MOST 107-2113-M-027-005-MY3 to SMC) is gratefully acknowledged.

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  1. Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10608, Taiwan

    Ramaraj Sukanya, Settu Ramki & Shen-Ming Chen

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  1. Ramaraj Sukanya
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Sukanya, R., Ramki, S. & Chen, SM. Ultrasound supported synthesis of tantalum carbide integrated functionalized carbon composite for the voltammetric determination of the antibacterial drug nitrofurantoin in pharmaceutical samples. Microchim Acta 187, 342 (2020). https://doi.org/10.1007/s00604-020-04314-7

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