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A non-enzymatic voltammetric xanthine sensor based on the use of platinum nanoparticles loaded with a metal-organic framework of type MIL-101(Cr). Application to simultaneous detection of dopamine, uric acid, xanthine and hypoxanthine

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Abstract

A Cr-based metal-organic framework MIL-101(Cr) was used to load platinum nanoparticles (PtNPs) that were placed on a glassy carbon electrode (GCE). The modified GCE was used as a non-enzymatic xanthine sensor. Compared to bare GCE, it requires a strongly decreased working potential and an increased signal current for xanthine oxidation. This is due to the crystalline ordered structure and large specific surface of the MIL-101(Cr), and to the high conductivity of the Pt NPs. Differential pulse voltammetry (DPV) shows the sensor to have a wide linear range (0.5 – 162 μM), a low detection limit (0.42 μM), and high selectivity. It was applied to the simultaneous determination of dopamine, uric acid, xanthine and hypoxanthine at working potentials of 0.13, 0.28, 0.68 and 1.05 V, respectively (vs. Ag/AgCl) and to quantify xanthine in spiked serum samples.

This is the first report of non-enzymatic xanthine electrochemical sensor based on metal-organic framework loaded with nanoparticles.

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Acknowledgments

This work was financially supported by the NSF of China (21671049, 51572063, 21603113 and 21701037), postdoctoral science foundation, China (2017 M611380).

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Authors and Affiliations

  1. School of Materials Science and Engineering, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin, 150040, China

    Li Zhang, Shaobin Li, Jianjiao Xin, Huiyuan Ma, Haijun Pang, Lichao Tan & Xinming Wang

  2. College of Materials Science and Engineering, Heilongjiang Provincial Key Laboratory of Polymeric Composite Materials, Qiqihar University, Qiqihar, 161006, China

    Shaobin Li

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Zhang, L., Li, S., Xin, J. et al. A non-enzymatic voltammetric xanthine sensor based on the use of platinum nanoparticles loaded with a metal-organic framework of type MIL-101(Cr). Application to simultaneous detection of dopamine, uric acid, xanthine and hypoxanthine. Microchim Acta 186, 9 (2019). https://doi.org/10.1007/s00604-018-3128-4

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