Abstract
Graphene nanoplatelets were dispersed in a Nafion matrix and used to modify a glassy carbon electrode for rapid determination of quetiapine (QTP) at the working potential of +990 mV (vs. Ag/AgCl). The material was deposited by drop-casting and characterized by scanning electron microscopy. Owing to the unique properties of graphene and the accumulation capability of the anionic polymer for the cationic target analyte, the modified electrode has a strongly improved limit of detection (22 nM) and works in the 100 nM to 10 μM concentration range. Low-cost quantification of QTP in urine samples without prior extraction was achieved after selective adsorption of QTP at the surface using differential pulse voltammetry. In comparison with HPLC method, the modified electrode allows simpler analysis of QTP in enteric-coated tablets that takes 40 s only.
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References
Daly EJ, Trivedi MH (2007) A review of quetiapine in combination with antidepressant therapy in patients with depression. Neuropsychiatr Dis Treat 3:855–867
Piróg-Balcerzak A, Habrat B, Mierzejewski P (2015) Misuse and abuse of quetiapine. Psychiatr Pol 49:81–93
Barrett B, Holcapek M, Huclova J, Borek-Dohalsky V, Fejt P, Memec B, Jelinek I (2007) Validated HPLC-MS/MS method for determination of quetiapine in human plasma. J Pharm Biomed Anal 44:498–505
Davis PC, Bravo O, Gehrke M, Azumaya CT (2010) Development and validation of an LC-MS/MS method for the determination of quetiapine and four related metabolites in human plasma. J Pharm Biomed Anal 51:1113–1119
Pan RN, Kuo BP, Pao LH (2012) Validated LC-MS-MS method for the determination of quetiapine in human plasma: application to a pharmacokinetic study. J Chromatogr Sci 50:277–282
Binz TM, Yegles M, Schneider S, Neels H, Crunelle CL (2014) Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS. Forensic Sci Int 242:200–203
Saracino MA, Mercolini L, Flotta G, Albers LJ, Merli R, Raggi MA (2006) Simultaneous determination of fluvoxamine isomers and quetiapine in human plasma by means of high-performance liquid chromatography. J Chrom B 843:227–233
Kumar N, Sangeetha D, Goyal R, Reddy PS (2013) A validated stability-indicating RP-LC method for the estimation of process-related impurities and degradation products of quetiapine fumarate in solid oral dosage form. Acta Chromatogr 25:393–409
Proenca P, Franco JM, Mustra C, Monteiro C, Costa J, Corte-Real F, Vieira DN (2013) UPLC-MS/MS determination in blood of a mixed-drug fatal intoxication: A case report. Forensic Sci Int 227:85–89.
da Fonseca BM, Moreno IE, Barroso M, Costa S, Queiroz JA, Gallardo E (2013) Determination of seven selected antipsychotic drugs in human plasma using microextraction in packed sorbent and gas chromatography-tandem mass spectrometry. Anal Bioanal Chem 405:3953–3963.
Lopez-Guarnido O, Tabernero MJ, Hernandez AF, Rodrigo L, Bermejo AM (2014) Rapid determination of quetiapine in blood by gas chromatography-mass spectrometry. Appl Post-Mortem Cases J Appl Toxicol 34:1104–1108.
Skibinski R, Komsta L, Kosztyla I (2008) Comparative validation of quetiapine determination in tablets by NP-HPTLC and RP-HPTLC with densitometric and videodensitometric detection. JPC-J Planar Chromatog-Mod TLC 21:289–294
Bellomarino SA, Brown AJ, Conlan XA, Barnett NW (2009) Preliminary evaluation of monolithic column high-performance liquid chromatography with tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection for the determination of quetiapine in human body fluids. Talanta 77:1873–1876
Wang YR, Yang YH, Lu CY, Lin SJ, Chen SH (2013) Trace analysis of acetylcholinesterase inhibitors with antipsychotic drugs for Alzheimer’s disease by capillary electrophoresis with on column field-amplified sample injection. Anal Bioanal Chem 405:3233–3242.
Wei F, Lin Y, Wu Y, Sun X, Liu L, Zhou P, Hu Q (2014) Double shell CdTe/CdS/ZnS Quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets. Anal Methods 6:482–489.
Rajendraprasad N, Basavaiah K, Vinay KB (2012) Extractive spectrophotometric determination of quetiapine fumarate in pharmaceuticals and spiked human urine. Croat Chem Acta 85:9–17.
Uřinovská R, Brozmanová H, Sištík P, Silhán P, Kacířová I, Lemr K, Grundmann M (2012) Liquid chromatography-tandem mass spectrometry method for determination of five antidepressants and four atypical antipsychotics and their main metabolites in human serum. J Chromatogr B 907:101–107
Ansermot N, Brawand-Amey M, Kottelat A, Eap CB (2013) Fast quantification of ten psychotropic drugs and metabolites in human plasma by Ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring. J Chromatogr A 1292:160–172
Amundsen I, Oiestad AM, Ekeberg D, Kristoffersen L (2013) Quantitative determination of fifteen basic pharmaceuticals in ante- and post-mortem whole blood by high pH mobile phase reversed phase Ultra high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B 927:112–123
Yang TH, Cai PS, Li D, Chen J, Xiong CM, Ruan JL, Wang LY (2014) Gamma-MPS-modified silica conical microcolumn separation/preconcentration of trace antipsychotic drugs in rat plasma and environmental water samples prior to their determination by LC. Chromatographia 77:1623–1632
de Souza ID, Domingues SD, Queiroz MEC (2015) Hybrid silica monolith for microextraction by packed sorbent to determine drugs from plasma samples by liquid chromatography-tandem mass spectrometry. Talanta 140:166–175
Oyama M (2010) Recent nanoarchitectures in metal nanoparticle-modified electrodes for electroanalysis. Anal Sci 26:1–12
Barsan MM, Ghica ME, Brett CM (2015) Electrochemical sensors and biosensors based on redox polymer/carbon nanotube modified electrodes: A review. Anal Chim Acta 881:1–23
Nigović B, Sadiković M, Sertić M (2014) Multi-walled carbon nanotubes/nafion composite film modified electrode as a sensor for simultaneous determination of ondansetron and morphine. Talanta 122:187–194
Sadiković M, Nigović B, Jurić S, Mornar A (2014) Voltammetric determination of ropinirole in the presence of levodopa at the surface of a carbon nanotubes based electrochemical sensor in pharmaceuticals and human serum. J Electroanal Chem 733:60–68
Ozkan SA, Dogan B, Uslu B (2006) Voltammetric analysis of the novel atypical antipsychotic drug quetiapine in human serum and urine. Microchim Acta 154:27–35
El-Enany N, El-Brashy A, Belal F, El-Bahay N (2009) Polarographic analysis of quetiapine in pharmaceuticals. Port Electrochim Acta 27:113–125
Nigović B, Spajić J (2011) A novel electrochemical sensor for assaying of antipsychotic drug quetiapine. Talanta 86:393–399
Ramachandran R, Mani V, Chen S-M, Saraswathi R, Lou B-S (2013) Recent trends in graphene based electrode materials for energy storage devices and sensors applications. Int J Electrochem Sci 8:11680–11694
Kochmann S, Hirsch T, Wolfbeis OS (2012) Graphenes in chemical sensors and biosensors. TrAC Trends Anal Chem 39:87–113
The United States Pharmacopoeia, 38th ed. (2015) United States pharmacopeial convention, Rockville, MD
Sparshatt A, Jones S, Taylor D (2008) Quetiapine: dose-response relationship in schizophrenia. CNS Drugs 22:49–68
International Conference on Harmonization (2005) Validation of analytical procedures: Text and methodology Q2 (R1).http://www.ich.org/products/guidelines/quality/article/quality-guidelines.htm
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Nigović, B., Mornar, A. & Sertić, M. Graphene nanocomposite modified glassy carbon electrode for voltammetric determination of the antipsychotic quetiapine. Microchim Acta 183, 1459–1467 (2016). https://doi.org/10.1007/s00604-016-1781-z
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DOI: https://doi.org/10.1007/s00604-016-1781-z