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The effect of pentoxifylline on the healing of intestinal anastomosis in rats with experimental obstructive jaundice

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Abstract

The aims of this study were (1) to investigate the effect of experimental obstructive jaundice on the healing of intestinal anastomosis, and (2) to investigate the effect of pentoxifylline on the healing of intestinal anastomosis in rats with obstructive jaundice. Obstructive jaundice was induced in rats by the ligation and division of the common bile duct. Four days after this operation, either pentoxifylline or isotonic saline solution was administered intraperitoneally to these jaundiced rats and controls, and then intestinal anastomosis was performed. The concentrations of serum tumor necrosis factor α (TNF-α) and serum triglyceride of jaundiced and nonjaundiced rats were measured, and the quality of healing was evaluated by measuring the bursting preasure and hydroxyproline content of the anastomoses on the fifth and tenth days of anastomotic healing. Obstructive jaundice resulted in an impaired wound healing of the intestinal anastomosis in the rats. The administration of pentoxifylline to the jaundiced rats resulted in better anastomotic wound healing. The beneficial effects of pentoxifylline on anastomotic healing in rats with obstructive jaundice was attributed to its inhibitor effect on the endotoxin-induced TNF-α release from macrophages and monocytes, and the stabilizing effect on the neutrophils.

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Author notes

  1. Mustafa Cömert

    Present address: Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey

Authors and Affiliations

  1. Department of General Surgery, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey

    Ferit Taneri, Ercüment Tekin, Emin Ersoy, Selçuk Öktemer & Erhan Onuk

  2. Department of Biochemistry, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey

    Ersel Düzgün

  3. Department of Public Health, Gazi University, Faculty of Medicine, 9 Eylül Sokak No. 47/3 Topraklik, Ankara, Turkey

    Ferruh Ayoĝlu

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Cömert, M., Taneri, F., Tekin, E. et al. The effect of pentoxifylline on the healing of intestinal anastomosis in rats with experimental obstructive jaundice. Surg Today 30, 896–902 (2000). https://doi.org/10.1007/s005950070041

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