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Remnant gastritis in gastric cancer patients causes loss of muscle mass 6 months after gastrectomy: a retrospective cohort study of Helicobacter pylori infection

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Abstract

Purpose

In this study, we assessed the relationship between remnant gastritis and muscle mass loss and then investigated the potential relationship between Helicobacter pylori (HP) infection and remnant gastritis and muscle loss.

Methods

We reviewed the medical records of 463 patients who underwent distal gastrectomy between January 2017 and March 2020. Of these patients, 100 with pStage I after laparoscopic surgery were included in this analysis.

Results

A multivariate analysis showed that the total Residue, Gastritis, Bile (RGB) classification score, which indicates the degree of gastritis, was significantly associated with the rate of change (rate of decrease) in the psoas muscle area (PMA) during the first 6 months after surgery (p = 0.014). Propensity score matching was performed according to HP infection, and the rate of change in the PMA and the degree of remnant gastritis in 56 patients were compared. Neither was significantly associated with HP infection.

Conclusions

Remnant gastritis did contribute to psoas muscle mass loss during the initial 6 months after gastrectomy, and HP infection was not significantly associated with either remnant gastritis or psoas muscle mass loss. Nevertheless, the potential for HP eradication to prevent muscle loss and improve the survival prognosis for gastrectomy patients merits further research.

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Funding

There is no specific grant from any funding agency in the public, commercial, or not-for-profit sectors associated with this study.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, 350-1298, Japan

    Shiro Fujihata, Shinichi Sakuramoto, Yosuke Morimoto, Kazuaki Matsui, Keiji Nishibeppu, Gen Ebara, Shohei Fujita, Shuichiro Oya, Hirofumi Sugita, Seigi Lee, Yutaka Miyawaki & Hiroshi Sato

  2. Department of Surgery, Narita Memorial Hospital, 134 Hanei-Honmchi, Toyohashi, Aichi, Japan

    Shiro Fujihata

  3. Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho-Cho, 1 Kawasumi, Mizuho-Ku, Nagoya, Aichi, Japan

    Shiro Fujihata & Shuji Takiguchi

  4. Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, 1-15-1, Kitasato, Minami-Ku, Sagamihara, Kanagawa, Japan

    Keishi Yamashita

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  1. Shiro Fujihata
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  2. Shinichi Sakuramoto
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  9. Hirofumi Sugita
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  14. Keishi Yamashita
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Correspondence to Shiro Fujihata.

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Fujihata, S., Sakuramoto, S., Morimoto, Y. et al. Remnant gastritis in gastric cancer patients causes loss of muscle mass 6 months after gastrectomy: a retrospective cohort study of Helicobacter pylori infection. Surg Today 54, 152–161 (2024). https://doi.org/10.1007/s00595-023-02712-x

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