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Updates in aortic wall pathology

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Abstract

Several studies have investigated the pathogenesis of aortic wall abnormalities such as aortic dissection or aneurysm; however, the comprehensive pathological in situ event involved in the development of the disease is not understood well. The vasa vasorum form a network of capillaries or venules around the adventitia and outer media, which play an important role in the aortic wall structure and function. Impairment of their function may induce tissue hypoxia, impede the transfer of cellular nutrients, and cause aortic medial degeneration, which is considered the major predisposing factor to this aortic wall pathology. This review updates our understanding of the pathological changes in the aortic media and vasa vasorum of patients with aortic dissection and aortic aneurysm.

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Acknowledgements

We wish to acknowledge the late Dr. Masahisa Kyogoku for his deep perspectives investigating the etiology of aortic dissection. We thank Mr. Wataru Takayanagi from LAIMAN (www.laiman.co.jp) for his help with creating Figs. 3 and 4.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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  1. Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan

    Hiroaki Osada & Kenji Minatoya

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Osada, H., Minatoya, K. Updates in aortic wall pathology. Surg Today 52, 1671–1679 (2022). https://doi.org/10.1007/s00595-021-02420-4

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