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RETRACTED ARTICLE: Inhaled tiotropium to prevent postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery

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This article was retracted on 15 November 2021

This article has been updated

Abstract

Purpose

A new diagnosis of chronic obstructive pulmonary disease is often made during the evaluation of patients requiring lung cancer surgery. The objective of the present study was to evaluate the clinical effects of inhaled tiotropium on the postoperative cardiopulmonary complications in patients with untreated chronic obstructive pulmonary disease requiring lung cancer surgery.

Methods

A retrospective study involving 104 consecutive patients with moderate to severe chronic obstructive pulmonary disease who underwent a lobectomy for lung cancer at two specialized thoracic centers between April 2008 and October 2011 was performed. The results were compared between patients who did and did not receive inhaled tiotropium during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. The postoperative white blood cell counts and C-reactive protein levels as biomarkers of inflammation were also examined.

Results

The incidence of postoperative cardiopulmonary complications was significantly lower in the tiotropium group than in the control group (18 vs. 48 %, P = 0.001). Patients in the tiotropium group also showed significantly lower white blood cell counts and C-reactive protein levels postoperatively.

Conclusions

Inhaled tiotropium treatment during the perioperative period had a prophylactic effect on postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery.

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References

  1. Loganathan RS, Stover DE, Shi W, Venkatraman E. Prevalence of COPD in women compared to men around the time of diagnosis of primary lung cancer. Chest. 2006;129:1305–12.

    Article  Google Scholar 

  2. Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J. 2009;34:380–6.

    Article  CAS  Google Scholar 

  3. Bednarek M, Maciejewski J, Wozniak M, Kuca P, Zielinski J. Prevalence, severity and underdiagnosis of COPD in the primary care setting. Thorax. 2008;63:402–7.

    Article  CAS  Google Scholar 

  4. Win T, Jackson A, Sharples L, Groves AM, Wells FC, Ritchie AJ, et al. Relationship between pulmonary function and lung cancer surgical outcome. Eur Respir J. 2005;25:594–9.

    Article  CAS  Google Scholar 

  5. Sekine Y, Kesler KA, Behnia M, Brooks-Brunn J, Sekine E, Brown JW. COPD may increase the incidence of refractory supraventricular arrhythmias following pulmonary resection for non-small cell lung cancer. Chest. 2001;120:1783–90.

    Article  CAS  Google Scholar 

  6. Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2012) Global strategy for diagnosis, management, and prevention of COPD. 2010 (Updated). Available from http://www.goldcopd.org/. Accessed 1 June 2012.

  7. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, UPLIFT Study Investigators, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543–54.

    Article  CAS  Google Scholar 

  8. Mills NL, Miller JJ, Anand A, Robinson SD, Frazer GA, Anderson D, et al. Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk. Thorax. 2008;63:306–11.

    Article  CAS  Google Scholar 

  9. Celli B, Decramer M, Leimer I, Vogel U, Kesten S, Tashkin DP. Cardiovascular safety of tiotropium in patients with COPD. Chest. 2010;137:20–30.

    Article  CAS  Google Scholar 

  10. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, ATS/ERS Task Force, et al. Standardisation of spirometry. Eur Respir J. 2005;26:319–38.

    Article  CAS  Google Scholar 

  11. Nojiri T, Inoue M, Yamamoto K, Maeda H, Takeuchi Y, Funakoshi Y, et al. B-type natriuretic peptide as a predictor of postoperative cardiopulmonary complications in elderly patients undergoing pulmonary resection for lung cancer. Ann Thorac Surg. 2011;92:1051–5.

    Article  Google Scholar 

  12. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011;14(342):d3215.

    Article  Google Scholar 

  13. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300:1439–50.

    Article  CAS  Google Scholar 

  14. Kearney DJ, Lee TH, Reilly JJ, DeCamp MM, Sugarbaker DJ. Assessment of operative risk in patients undergoing lung resection. Importance of predicted pulmonary function. Chest. 1994;105:753–9.

    Article  CAS  Google Scholar 

  15. Kobayashi S, Suzuki S, Niikawa H, Sugawara T, Yanai M. Preoperative use of inhaled tiotropium in lung cancer patients with untreated COPD. Respirology. 2009;14:675–9.

    Article  Google Scholar 

  16. Arai N, Kondo M, Izumo T, Tamaoki J, Nagai A. Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice. Eur Respir J. 2010;35:1164–71.

    Article  CAS  Google Scholar 

  17. Cosio MG, Guerassimov A. Chronic obstructive pulmonary disease: inflammation of small airways and lung parenchyma. Am J Respir Crit Care Med. 1999;160:S21–5.

    Article  CAS  Google Scholar 

  18. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59:574–80.

    Article  CAS  Google Scholar 

  19. Maclay JD, McAllister DA, Macnee W. Cardiovascular risk in chronic obstructive pulmonary disease. Respirology. 2007;12:634–41.

    Article  Google Scholar 

  20. Vacca G, Randerath WJ, Gillissen A. Inhibition of granulocyte migration by tiotropium bromide. Respir Res. 2011;12:24.

    Article  CAS  Google Scholar 

  21. Wollin L, Pieper MP. Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD. Pulm Pharmacol Ther. 2010;23:345–54.

    Article  CAS  Google Scholar 

  22. Tsang TS, Barnes ME, Gersh BJ, Bailey KR, Seward JB. Risks for atrial fibrillation and congestive heart failure in patients ≥65 years of age with abnormal left ventricular diastolic relaxation. Am J Cardiol. 2004;93:54–8.

    Article  Google Scholar 

  23. Nojiri T, Maeda H, Takeuchi Y, Funakoshi Y, Maekura R, Yamamoto K, et al. Predictive value of preoperative tissue Doppler echocardiographic analysis for postoperative atrial fibrillation after pulmonary resection for lung cancer. J Thorac Cardiovasc Surg. 2010;140:764–8.

    Article  Google Scholar 

  24. Nojiri T, Maeda H, Takeuchi Y, Funakoshi Y, Maekura R, Yamamoto K, et al. Effects of inhaled tiotropium on left ventricular diastolic function in chronic obstructive pulmonary disease patients after pulmonary resection. Ann Thorac Cardiovasc Surg. 2012;18:206–11.

    Article  Google Scholar 

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Acknowledgments

No financial support for the study was provided by any organization.

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 (L5) Yamadaoka, Suita, Osaka, 565-0871, Japan

    Takashi Nojiri, Masayoshi Inoue, Tomoyuki Nakagiri, Yasushi Shintani, Masato Minami, Noriyoshi Sawabata & Meinoshin Okumura

  2. Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Toyonaka, Osaka, Japan

    Takashi Nojiri, Hajime Maeda & Yukiyasu Takeuchi

  3. Department of Molecular Medicine and Therapeutics Faculty of Medicine, Tottori University Hospital, Yonago, Tottori, Japan

    Kazuhiro Yamamoto

Authors
  1. Takashi Nojiri
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  2. Masayoshi Inoue
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  3. Kazuhiro Yamamoto
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  4. Hajime Maeda
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  5. Yukiyasu Takeuchi
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  6. Tomoyuki Nakagiri
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  7. Yasushi Shintani
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  8. Masato Minami
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  9. Noriyoshi Sawabata
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  10. Meinoshin Okumura
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Corresponding author

Correspondence to Takashi Nojiri.

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Nojiri, T., Inoue, M., Yamamoto, K. et al. RETRACTED ARTICLE: Inhaled tiotropium to prevent postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery. Surg Today 44, 285–290 (2014). https://doi.org/10.1007/s00595-012-0481-5

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  • DOI: https://doi.org/10.1007/s00595-012-0481-5

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