Abstract
The adrenal gland can frequently be the site of metastatic deposits, including malignant melanocytic tumors; however, primary melanoma of the adrenal gland is exceptional. We reviewed 18 cases reported in the English literature to date, and here add another case which occurred in a 78-year-old man. The patient underwent right suprarenalectomy and the pathology report showed a malignant melanoma of the adrenal gland. Immunohistochemical staining revealed a positive antibody-specific cytoplasmic reactivity to S-100 and HMB-45 proteins with a negative reaction for cytokeratin (AE1, AE3), synaptophysin, chromogranin and neuron-specific enolase. There are diagnostic criteria for accepting an adrenal melanoma as primary; however, an autopsy is the final step to confirm this infrequent pathology.
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Granero, L., Al-Lawati, T. & Bobin, JY. Primary Melanoma of the Adrenal Gland, a Continuous Dilemma: Report of a Case. Surg Today 34, 554–556 (2004). https://doi.org/10.1007/s00595-004-2740-6
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DOI: https://doi.org/10.1007/s00595-004-2740-6