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Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus

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Abstract

Aims

People with type 2 diabetes mellitus (T2DM) have abnormal peripheral and central haemodynamics at rest and during exercise, probably due to metabolic perturbations, but mechanisms are unknown. We used untargeted metabolomics to determine the relationships between metabolic perturbations and haemodynamics (peripheral and central) measured at rest and during exercise.

Methods

Serum samples from 39 participants with T2DM (62 ± 9 years; 46 % male) and 39 controls (52 ± 10 years; 51 % male) were analysed by liquid chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy and principal component analysis. Scores on principal components (PC) were used to assess relationships with haemodynamics including peripheral and central BP, central augmentation index (AIx) and central augmentation pressure (AP).

Results

Participants with T2DM had higher resting and exercise haemodynamics (peripheral and central BP, central AIx and central AP) compared to controls (p < 0.05). PC that comprised of a signature metabolic pattern of T2DM was independently associated with resting and exercise central AIx and central AP (p < 0.05).

Conclusions

Serum metabolic profile was associated with central, but not peripheral, haemodynamics in T2DM participants, suggesting that metabolic irregularities may explain abnormal central haemodynamics in T2DM patients.

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Acknowledgments

The authors thank Ms. Laura J. Keith for significant contribution towards data collection.

Sources of funding

This study was partly supported with a Diabetes Australia Research Grant (Reference Y11SHAJ).

Author information

Authors and Affiliations

  1. Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, 7000, Australia

    Sonja B. Nikolic & James E. Sharman

  2. Centre of Human and Aerospace Physiological Sciences, King’s College London, London, UK

    Lindsay M. Edwards

  3. Fibrosis Discovery Performance Unit, GSK Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK

    Lindsay M. Edwards

  4. School of Mathematics and Physics, University of Tasmania, Hobart, Australia

    Yuliya V. Karpievitch

  5. Central Science Laboratory, University of Tasmania, Hobart, Australia

    Richard Wilson & James Horne

  6. School of Health Sciences, University of Tasmania, Launceston, Australia

    Murray J. Adams

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  1. Sonja B. Nikolic
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Corresponding authors

Correspondence to Lindsay M. Edwards or James E. Sharman.

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The authors declare that they have no conflict of interest.

Human and Animal Rights disclosure

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5).

Informed consent disclosure

Informed consent was obtained from all patients for being included in the study.

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Nikolic, S.B., Edwards, L.M., Karpievitch, Y.V. et al. Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus. Acta Diabetol 53, 367–375 (2016). https://doi.org/10.1007/s00592-015-0802-4

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  • DOI: https://doi.org/10.1007/s00592-015-0802-4

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