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Percutaneous treatments of primary aneurysmal bone cysts: systematic review and meta-analysis

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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Purpose

To systematically review the literature to determine recurrence rates of percutaneous treatments for primary aneurysmal bone cysts (ABC).

Methods

Search strategies were performed in the following databases: PubMed, SCIELO, LILACS and BVS, using terms in English, Spanish and Portuguese (PROSPERO Registration Number: CRD42020170340). Longitudinal studies, either observational or clinical trials, with at least five patients and with a mean of 18 months of follow-up were included. Studies had to use any type of percutaneous treatments and report the recurrence rates of primary ABC treatment. Studies selection, data extraction and risk of bias assessment were performed independently by two researchers. A global meta-analysis was carried out to assess the proportion of recurrence. Studies were categorized into two subgroups: selective arterial embolization and sclerotherapy.

Results

Thirteen studies were included in the present study. The average success rate of percutaneous treatments for ABC was 91.11%, with a total of 37 lesions recurrences in the 416 patients. The sex ratio was 1:1. The subgroup of sclerotherapies presented a lower proportion of recurrence. The proportion of recurrence in the subgroup of selective arterial embolization was 19% (95%IC 12.11–27.54) and that of sclerotherapies was 6% (95%IC 3.65–9.19).

Conclusions

Both percutaneous treatments for ABC are effective, showing a lower rate of recurrence. Sclerotherapy treatments seem to be promising, but further clinical trials must be conducted with a longer follow-up.

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Data will be forwarded upon request.

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Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. All other funding was self-supported by the authors.

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Authors and Affiliations

  1. Universidade Federal de Pelotas, Pelotas, Brazil

    Gabriel Schmitt Cruz, Rafael Giorgis & Matheus Ricardo Kishimoto Teixeira

  2. Universidad Autónoma del Estado de Hidalgo, Pachuca, Mexico

    Carlos Enrique Cuevas-Suárez

  3. Universidad de Chile, Santiago, Chile

    Juan Pablo Aitken Saavedra

  4. Department of Periodontology, Universidade Federal de Pelotas, Rio Grande Do Sul, Rua Gonçalves Chaves, 457, Pelotas, CEP: 96015-560, Brazil

    Francisco Wilker Mustafa Gomes Muniz

Authors
  1. Gabriel Schmitt Cruz
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  2. Carlos Enrique Cuevas-Suárez
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  3. Juan Pablo Aitken Saavedra
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  4. Rafael Giorgis
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  5. Matheus Ricardo Kishimoto Teixeira
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  6. Francisco Wilker Mustafa Gomes Muniz
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Contributions

GSC, ECS, JPAS, RG and FWMGM designed the study. GSC and MRKT selected the studies and extracted the data. GSC and CECS analyzed the risk of bias. GSC performed data analysis. FWMGM helped in study selection, data extraction and risk of bias analysis. JPAS and RG validated the results. FWMGM and CECS supervised the study. GSC and FWMGM wrote the manuscript. All other authors approved the final version of the manuscript.

Corresponding author

Correspondence to Francisco Wilker Mustafa Gomes Muniz.

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Cruz, G.S., Cuevas-Suárez, C.E., Saavedra, J.P.A. et al. Percutaneous treatments of primary aneurysmal bone cysts: systematic review and meta-analysis. Eur J Orthop Surg Traumatol 31, 1287–1295 (2021). https://doi.org/10.1007/s00590-021-02893-6

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  • DOI: https://doi.org/10.1007/s00590-021-02893-6

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