Abstract
Purpose
Metastatic spinal cord compression (MSCC) incidences are increasing. Our objective was to identify predictive factors involved in long-term survival after use of a surgical approach.
Methods
We retrospectively analyzed all patients referred to our institution for MSCC who underwent surgery (N = 138). We identified patients with an overall survival (OS) rate greater than 2 years, compared their characteristics to the remaining patients, and performed recursive partitioning analysis (RPA).
Results
Median OS was 7.8 months (95 % confidence interval 4.4–11.2). Thirty-nine patients presented with OS ≥2 years. A comparative analysis found significant differences concerning the delay (first symptom–surgery, p < 0.001), number of systemic (p = 0.001) or bone metastases (p = 0.013), Karnofsky performance status (KPS) (p = 0.006), Frankel (p = 0.025), ASA scores (p < 0.001), weight loss (p = 0.003), hyperalgia (p = 0.002), chemotherapy use (p = 0.034), and primary tumor (p < 0.001). RPA classification identified six prognostic classes based on the ASA score, primary type, KPS, and systemic metastases.
Conclusion
Long-term metastatic cancer survivor patients are an increasing population with specific characteristics.
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Recursive partitioning analysis (RPA) identified three prognostic classes of patients (overall survival in months and 95 % confidence interval). (TIFF 198 kb)
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Tabouret, E., Gravis, G., Cauvin, C. et al. Long-term survivors after surgical management of metastatic spinal cord compression. Eur Spine J 24, 209–215 (2015). https://doi.org/10.1007/s00586-014-3676-1
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DOI: https://doi.org/10.1007/s00586-014-3676-1