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CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis

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Abstract

Canine generalised demodicosis is recognised as a severe skin disease of dogs, and studies on CD4+ and CD8+ T cells in this disease condition have been limited. The aim of the present study was to record the CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis. Whole blood was collected from dogs with generalised demodicosis for estimation of CD4+ and CD8+ T cells by flow cytometry. The demodicosis-affected dogs had lower number of CD4+ T cells, increased CD8+ T cells, and reduced CD4+/CD8+ ratio compared to healthy controls. Present abnormalities in the study are related to the immunological response of the dogs to the mites in a disease process.

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Acknowledgments

The authors would like to thank Mr. S. Jaganmohan Reddy for the flow cytometry examination of the peripheral blood in the present study. The authors are thankful to authorities of the SVVU for providing the facilities to carry out the present work.

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Correspondence to B. Sudhakara Reddy.

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Reddy, B.S., Sivajothi, S. CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis. Comp Clin Pathol 25, 295–297 (2016). https://doi.org/10.1007/s00580-015-2180-2

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  • DOI: https://doi.org/10.1007/s00580-015-2180-2

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