Abstract
Canine generalised demodicosis is recognised as a severe skin disease of dogs, and studies on CD4+ and CD8+ T cells in this disease condition have been limited. The aim of the present study was to record the CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis. Whole blood was collected from dogs with generalised demodicosis for estimation of CD4+ and CD8+ T cells by flow cytometry. The demodicosis-affected dogs had lower number of CD4+ T cells, increased CD8+ T cells, and reduced CD4+/CD8+ ratio compared to healthy controls. Present abnormalities in the study are related to the immunological response of the dogs to the mites in a disease process.
Similar content being viewed by others
References
Blount DG, Pritchard DI, Heaton PR (2005) Age related alterations to immune parameters in Labrador retriever dogs. Vet Immunol Immunopathol 108:399–407
Faldyna ML, Leva L, Knotigova P, Toman M (2001) Lymphocyte subsets in peripheral blood of dogs a flow cytometric study. Vet Immunol Immunopathol 82:23–37
Fukata T, Fuoki S, Yoshikawa H, Kambayashi Y, Kito K, Kitagawa H (2005) Significance of the CD4/CD8 lymphocytes ratio in dogs suffering from demodicosis. J Jpn Vet Med Assoc 58:113–116
Reddy BS, Kumari KN (2010) Demodicosis and its successful management in dogs. Ind J Field Veterinarians 6(2):48–50
Reddy BS, Sivajothi S (2014) Notoedric mange associated with Malassezia in cats. Int J Vet Health Sci Res 02(01):18–20
Reddy BS, Kumari KN, Sivajothi S, Venkatasivakumar R (2014) Dermatitis due to mixed Demodex and Sarcoptes mites in dogs. Hindawi Publishing Corporation Case Reports in Veterinary Medicine Volume 2014, Article ID 768242, 4 pages doi:10.1155/2014/768242
Reddy BS, Kumari KN, Sivajothi S (2015) Haemato–biochemical findings and thyroxin levels in canine demodicosis. Comp Clin Pathol 24(2):287--290. doi:10.1007/s00580-014-1893-y
Singh SK, Dimri U, Sharma MC, Sharma B, Saxena M (2010) Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with demodicosis. Parasitology 137(13):1921–4
Sivajothi S, Reddy BS (2015) Cat affected with sarcoptic mange in YSR District of Andhra Pradesh, India. Comp Clin Pathol 24(5):1031--1032. doi:10.1007/s00580-014-2023-6
Acknowledgments
The authors would like to thank Mr. S. Jaganmohan Reddy for the flow cytometry examination of the peripheral blood in the present study. The authors are thankful to authorities of the SVVU for providing the facilities to carry out the present work.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Reddy, B.S., Sivajothi, S. CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis. Comp Clin Pathol 25, 295–297 (2016). https://doi.org/10.1007/s00580-015-2180-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00580-015-2180-2