Abstract
We observed the relative changes of both spinal cord blood flow (local SCBF) and local cerebral blood flow (local CBF) using independent laser-Doppler flowmeters (LDF) in 12 dogs under N2O(50%)-O2-enflurane(1.0%) anesthesia. The dorsal surface of the lumbar spinal cord and the parietal surface of the brain were partially exposed. Two fine LDF probes were placed between the exposed surfaces and the dura maters at each site. Both local SCBF and local CBF decreased simultaneously with hyperventilation and incresed with hypoventilation within several seconds. The local SCBF responses to\(Pa_{CO_2 } \) changes were similar in direction and degree as those of the local CBF. Autoregulation of local SCBF to arterial blood pressure (ABP) changes was abolished, though that of the local CBF was still recognized in a blunted fashion within a mean ABP range of 50 to 150 mmHg.
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References
Bonner RF, Clem TR, Bowen PD, et al: Laser-Doppler continuous realtime monitor of pulsatile and mean blood flow in tissue microcirculation, Scattering Techniques Applied to Supramolecular and Non-Equilibrium Systems. Edited by Chen SH, Chu B, Nossal R. New York, Plenum, 1981, pp. 85–702
Rosemblum BR, Bonner RF, Oldfield EH: Intraoperative measurement of cortical blood flow adjacent to cerebral AVM using laser Doppler velocimetry. J Neurosurg 66:396–399, 1987
Lindsberg PJ, O’eill JT, PaakkariIA, et al: Validation of laser-Doppler flowmetry in measurement of spinal cord blood flow. Am J Physiol 257:674–680, 1989
Flohr HW, Poll W, Brock M: Regulation of spinal blood flow. Brain and blood flow. Edited by Ross Rusell RW. London, Pitman, 1970, pp. 406409
Griffiths IR: Spinal cord blood flow in dogs. 2. The effect of the blood gases. J Neurol Neurosurg Psychiat 36:42–49, 1973
Jacobs HK, Lieponis JV, Bunch WH, et al: The influence of halothane and nitroprusside on canine spinal cord hemodynamics. Spine 7:35–40, 1982
Kobrine AI, Doyle TF: Physiology of spinal cord blood flow. Blood flow and metabolism in the brain. Edited by Harper AM, Jennet WB, Miller JD, Rowan JO. Edinburgh, ChurchillLivingstone, 1975, pp. 4.16–4.19
Hoffman WE, Edelman GJ, Segil LJ, et al: Cerebral autoregulation in awake versus isoflurane-anesthetized rats. Anesth Analg 73:753–757, 1991
Scremin OU, Decima EE: Control of blood flow in the cat spinal cord. J Neurosurg 58:742–748, 1983
Kindt GW: Autoregulation of spinal cord blood flow. Eur Neurol 6:19–23, 1971/72
Griffiths IR: Spinal cord blood flow in dogs: the effect of blood pressure. J Neurol Neurosurg Psychiat 36:914–920, 1973
Kobrine AI, Doyle TF, Rizzoli HV: Spinal cord blood flow as affected by changes in systemic arterial blood pressure. J Neurosurg 44:12–15, 1976
Hickey R, Albin MS, Bunegin L, et al: Autoregulation of spinal cord blood flow: Is the cord a microcosm of the brain? Stroke 17:1183–1189, 1986
Wilton NCT, Tait AR, Kling TF, et al: The effect of trimetaphan-induced hypotension on canine spinal cord blood flow. Spine 13:490–493, 1988
Kobrine AI, Evans DE, Rizzoli HV: The effect of beta adrenergic blockade on spinal cord autoregulation in the monkey. J Neurosurg 47:57–63, 1977
Kobrine AI, Evans DE, Rizzoli HV: The effect of alpha adrenergic blockade on spinal cord autoregulation in the monkey. J Neurosurg 46: 336–341, 1977
Sandler AN, Tator CH: Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates. J Neurosurg 45:660–676, 1976
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Sadanaga, M., Kano, T., Hashiguchi, A. et al. Simultaneous laser-doppler flowmetry of canine spinal cord and cerebral blood flow: Responses to\(Pa_{CO_2 } \) and blood pressure changes. J Anesth 7, 427–433 (1993). https://doi.org/10.1007/s0054030070427
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DOI: https://doi.org/10.1007/s0054030070427