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Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer

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Abstract

Purpose

Little is known about the impact of decreased walking capacity on clinical outcomes in elderly patients with cancer. This prospective observational study aimed to investigate the impact of walking capacity on the risk of disability and hospitalization in elderly patients with advanced lung cancer.

Method

This study prospectively enrolled 60 patients aged ≥ 70 years with advanced non-small-cell lung cancer (NSCLC) scheduled to receive first-line chemotherapy or radical radiotherapy between January 2013 and December 2014 (trial registration number: UMIN000009768). Patients were classified into the mobile or less mobile group based on the median incremental shuttle walking distance (ISWD) before initial treatment. Assessments included the Barthel index, disability-free survival time, mean cumulative lengths of hospital stay, and inpatient medical costs.

Results

The median ISWD was 290 m (interquartile range, 245–357.5 m). The mobile group (ISWD ≥ 290 m) had a longer disability-free survival time than the less mobile group (ISWD < 290 m, 24.6 months vs. 8.4 months, p < 0.05). During the first year from study entry, the mobile group had shorter cumulative lengths of hospital stay (41.3 vs. 72.9 days/person, p < 0.05) and lower inpatient medical costs (¥1.9 vs. ¥2.9 million/person, p < 0.05) than the less mobile group.

Conclusion

Elderly NSCLC patients with adequate walking capacity showed lower risks of disability, shorter hospitalizations, and lower inpatient medical costs than patients with reduced walking capacity. Further prospective research is needed to validate these findings. The trial was registered with the University Hospital Medical Information Network as trial number UMIN000009768 on January 13, 2013.

Trial registration

UMIN000009768

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

References

  1. Takayuki N, Keiko T, Junji U, Yoshiko K, Nobuyo T, Tadaaki Y, Koichi T (2018) Advanced non-small-cell lung cancer in elderly patients: patient features and therapeutic management. Biomed Res Int 30:8202971–8202978. https://doi.org/10.1155/2018/8202971

    Article  CAS  Google Scholar 

  2. Banegas MP, Yabroff KR, O’Keeffe-Rosetti MC, Ritzwoller DP, Fishman PA, Salloum RG, Lafata JE, Hornbrook MC (2018) Medical care costs associated with cancer in integrated delivery systems. J Natl Compr Canc Netw 16:402–410. https://doi.org/10.6004/jnccn.2017.7065

    Article  PubMed  Google Scholar 

  3. Yin X, Xu Y, Man X, Liu L, Jiang Y, Zhao L, Cheng W (2019) Direct costs of both inpatient and outpatient care for all type cancers: the evidence from Beijing, China. Cancer Med 8:3250–3260. https://doi.org/10.1002/cam4.2184

    Article  PubMed  PubMed Central  Google Scholar 

  4. Ministry of Health Law (2019) Estimates of medical care expenditure, summary for 2017. https://www.mhlw.go.jp/toukei/saikin/hw/k-iryohi/17/index.html. Accessed June 2, 2020

  5. Luengo-Fernandez R, Leal J, Gray A, Sullivan R (2013) Economic burden of cancer across the European Union: a population-based cost analysis. Lancet Oncol 14:1165–1174. https://doi.org/10.1016/S1470-2045(13)70442-X

    Article  PubMed  Google Scholar 

  6. Yi YS, Ban WH, Sohng KY (2018) Effect of COPD on symptoms, quality of life and prognosis in patients with advanced non-small cell lung cancer. BMC Cancer 18:1053. https://doi.org/10.1186/s12885-018-4976-3

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kimura M, Naito T, Kenmotsu H, Taira T, Wakuda K, Oyakawa T, Hisamatsu Y, Tokito T, Imai H, Akamatsu H, Ono A, Kaira K, Murakami H, Endo M, Mori K, Takahashi T, Yamamoto N (2015) Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer. Support Care Cancer 23:1699–1708. https://doi.org/10.1007/s00520-014-2534-3

    Article  PubMed  Google Scholar 

  8. Granger CL, Denehy L, McDonald CF, Irving L, Clark RA (2014) Physical activity measured using global positioning system tracking in non-small cell lung cancer: an observational study. Integr Cancer Ther 13:482–492. https://doi.org/10.1177/1534735414542484

    Article  PubMed  Google Scholar 

  9. Leach CR, Bellizzi KV, Hurria A, Reeve BB (2016) Is it my cancer or am I just getting older?: impact of cancer on age-related health conditions of older cancer survivors. Cancer 122:1946–1953. https://doi.org/10.1002/cncr.29914

    Article  PubMed  Google Scholar 

  10. Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version. Accessed at https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq on November 3, 2020

  11. Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, Shiozaki H, Murakami H, Kenmotsu H, Taira T, Ono A, Wakuda K, Imai H, Oyakawa T, Ishii T, Omori S, Nakashima K, Endo M, Omae K, Mori K, Yamamoto N, Tanuma A, Takahashi T (2017) Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study. BMC Cancer 17:800. https://doi.org/10.1186/s12885-017-3795-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, Shiozaki H, Murakami H, Kenmotsu H, Taira T, Ono A, Wakuda K, Imai H, Oyakawa T, Ishii T, Omori S, Nakashima K, Endo M, Omae K, Mori K, Yamamoto N, Tanuma A, Takahashi T (2017) Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non-small-cell lung cancer. BMC Cancer 17:571. https://doi.org/10.1186/s12885-017-3562-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Jones LW, Hornsby WE, Goetzinger A, Forbes LM, Sherrard EL, Quist M, Lane AT, West M, Eves ND, Gradison M, Coan A, Herndon JE, Abernethy AP (2012) Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer. Lung Cancer 76:248–252. https://doi.org/10.1016/j.lungcan.2011.10.009

    Article  PubMed  Google Scholar 

  14. Kasymjanova G, Correa JA, Kreisman H, Dajczman E, Pepe C, Dobson S, Lajeunesse L, Sharma R, Small D (2009) Prognostic value of the six-minute walk in advanced non-small cell lung cancer. J Thorac Oncol 4:602–607. https://doi.org/10.1097/JTO.0b013e31819e77e8

    Article  PubMed  Google Scholar 

  15. Singh SJ, Puhan MA, Andrianopoulos V, Hernandes NA, Mitchell KE, Hill CJ, Lee AL, Camillo CA, Troosters T, Spruit MA, Carlin BW, Wanger J, Pepin V, Saey D, Pitta F, Kaminsky DA, McCormack MC, MacIntyre N, Culver BH, Sciurba FC, Revill SM, Delafosse V, Holland AE (2014) An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. Eur Respir J 44:1447–1478. https://doi.org/10.1183/09031936.00150414

    Article  PubMed  Google Scholar 

  16. Singh SJ, Morgan MD, Scott S, Walters D, Hardman AE (1992) Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 47:1019–1024. https://doi.org/10.1136/thx.47.12.1019

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Guigoz Y, Vellas B, Garry PJ (1996) Assessing the nutritional status of the elderly: the mini nutritional assessment as part of the geriatric evaluation. Nutr Rev 54:S59–S65. https://doi.org/10.1111/j.1753-4887.1996.tb03793.x

    Article  CAS  PubMed  Google Scholar 

  18. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489–495. https://doi.org/10.1016/S1470-2045(10)70218-7

    Article  PubMed  Google Scholar 

  19. Martin L, Birdsell L, Macdonald N, Reiman T, Clandinin MT, McCargar LJ, Murphy R, Ghosh S, Sawyer MB, Baracos VE (2013) Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 31:1539–1547. https://doi.org/10.1200/JCO.2012.45.2722

    Article  PubMed  Google Scholar 

  20. Mourtzakis M, Prado CMM, Lieffers J, Reiman T, McCargar LJ, Baracos VE (2008) A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 33:997–1006. https://doi.org/10.1139/H08-075

    Article  PubMed  Google Scholar 

  21. Nelson W (1995) Confidence limits for recurrence data—applied to cost or number of product repairs. Technometrics 37:147–157. https://doi.org/10.1080/00401706.1995.10484299

    Article  Google Scholar 

  22. Smedira NG, Hoercher KJ, Lima B, Mountis MM, Starling R, Thuita L, Schmuhl D, Blackstone E (2013) Unplanned hospital readmissions after HeartMate II implantation: frequency, risk factors, and impact on resource use and survival. JACC Heart Fail 1:31–39. https://doi.org/10.1016/j.jchf.2012.11.001

    Article  PubMed  Google Scholar 

  23. Ishii S, Tanaka T, Shibasaki K, Ouchi Y, Kikutani T, Higashiguchi T, Obuchi SP, Ishikawa-Takata K, Hirano H, Kawai H, Tsuji T, Iijima K (2014) Development of a simple screening test for sarcopenia in older adults. Geriatr Gerontol Int 14(Suppl 1):93–101. https://doi.org/10.1111/ggi.12197

    Article  PubMed  Google Scholar 

  24. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, MA MB, Cardiovascular Health Study Collaborative Research Group (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156. https://doi.org/10.1093/gerona/56.3.m146

    Article  CAS  PubMed  Google Scholar 

  25. Sherrington C, Tiedemann A, Fairhall N, Close JCT, Lord SR (2011) Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations. N S W Public Health Bull 22:78–83. https://doi.org/10.1071/NB10056

    Article  PubMed  Google Scholar 

  26. Chen S, Qin J, Li Y, Wei Y, Long B, Cai J, Tang J, Xu X, Yu G, Zhang Z (2018) Disability and its influencing factors among the elderly in a county, Guangxi Province, China. Int J Environ Res Public Health 15:1967. https://doi.org/10.3390/ijerph15091967

    Article  PubMed Central  Google Scholar 

  27. García-Nogueras I, Aranda-Reneo I, Peña-Longobardo LM, Oliva-Moreno J, Abizanda P (2017) Use of health resources and healthcare costs associated with frailty: the FRADEA study. J Nutr Health Aging 21:207–214. https://doi.org/10.1007/s12603-016-0727-9

    Article  PubMed  Google Scholar 

  28. Arnau A, Espaulella J, Méndez T, Serrarols M, Canudas J, Formiga F, Ferrer M (2016) Lower limb function and 10-year survival in population aged 75 years and older. Family Pract 33:10–16. https://doi.org/10.1093/fampra/cmv088

    Article  Google Scholar 

  29. Morishita T, Sato M, Kume H, Sakuma M, Arai H, Katayama T, Katoh S, Sairyo K, Takeda E (2018) Skeletal muscle mass of old Japanese women suffering from walking difficulty in nursing home. J Med Invest 65:122–130. https://doi.org/10.2152/jmi.65.122

    Article  PubMed  Google Scholar 

  30. Misu S, Asai T, Doi T, Sawa R, Ueda Y, Saito T, Nakamura R, Murata S, Sugimoto T, Yamada M, Ono R (2017) Association between gait abnormality and malnutrition in a community-dwelling elderly population. Geriatr Gerontol Int 17:1155–1160. https://doi.org/10.1111/ggi.12839

    Article  PubMed  Google Scholar 

  31. Huang MH, Blackwood J, Godoshian M, Pfalzer L (2018) Factors associated with self-reported falls, balance or walking difficulty in older survivors of breast, colorectal, lung, or prostate cancer: results from surveillance, epidemiology, and end results-medicare health outcomes survey linkage. PLoS One 13:e0208573. https://doi.org/10.1371/journal.pone.0208573

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Wallengren O, Lundholm K, Bosaeus I (2013) Diagnostic criteria of cancer cachexia: relation to quality of life, exercise capacity and survival in unselected palliative care patients. Support Care Cancer 21:1569–1577. https://doi.org/10.1007/s00520-012-1697-z

    Article  PubMed  Google Scholar 

  33. Morikawa A, Naito T, Sugiyama M, Okayama T, Aoyama T, Tanuma A, Omae K, Takahashi T (2018) Impact of cancer cachexia on hospitalization-associated physical inactivity in elderly patients with advanced non-small-cell lung cancer. Asia Pac J Oncol Nurs 5:377–382. https://doi.org/10.4103/apjon.apjon_20_18

    Article  PubMed  PubMed Central  Google Scholar 

  34. Miyawaki A, Naito T, Nakashima K, Miyawaki T, Mamesaya N, Kawamura T, Kobayashi H, Omori S, Wakuda K, Ono A, Kenmotsu H, Murakami H, Mori K, Takahashi T (2020) Management of anorexia prevents skeletal muscle wasting during cisplatin-based chemotherapy for thoracic malignancies. JCSM Clinical Reports 5:8–15. https://doi.org/10.1002/crt2.8

    Article  Google Scholar 

  35. Fong JH, Feng J (2018) Comparing the loss of functional independence of older adults in the U.S. and China. Arch Gerontol Geriatr 74:123–127. https://doi.org/10.1016/j.archger.2017.10.020

    Article  PubMed  Google Scholar 

  36. Dunlop DD, Hughes SL, Manheim LM (1997) Disability in activities of daily living: patterns of change and a hierarchy of disability. Am J Public Health 87:378–383. https://doi.org/10.2105/ajph.87.3.378

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Shulman MA, Cuthbertson BH, Wijeysundera DN, Pearse RN, Thompson B, Torres E, Ambosta A, Wallace S, Farrington C, Myles PS, Measurement of Exercise Tolerance for Surgery Study Investigators (2019) Using the 6-minute walk test to predict disability-free survival after major surgery. Br J Anaesth 122:111–119. https://doi.org/10.1016/j.bja.2018.08.016

    Article  CAS  PubMed  Google Scholar 

  38. Cheng Y, Goodin A, Pahor M, Manini T, Brown JD (2020) Healthcare utilization and physical functioning in older adults in the United States. J Am Geriatr Soc 38:266–271. https://doi.org/10.1111/jgs.16260

    Article  Google Scholar 

  39. Fried TR, Bradley EH, Williams CS, Tinetti ME (2001) Functional disability and health care expenditures for older persons. Arch Intern Med 161:2602–2607. https://doi.org/10.1001/archinte.161.21.2602

    Article  CAS  PubMed  Google Scholar 

  40. Lin MH, Chen SR, Liao MN, Chen YC, Chang WY (2017) Factors and medical costs associated with fall events in hospitalized patients. Hu Li Za Zhi 64:44–52. https://doi.org/10.6224/JN.000053

    Article  PubMed  Google Scholar 

  41. Leal J, Gray AM, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A, REFReSH study group (2016) Impact of hip fracture on hospital care costs: a population-based study. Osteoporos Int 27:549–558. https://doi.org/10.1007/s00198-015-3277-9

    Article  CAS  PubMed  Google Scholar 

  42. Park H, Adeyemi AO, Rascati KL (2015) Direct medical costs and utilization of health care services to treat pneumonia in the United States: an analysis of the 2007-2011 Medical Expenditure Panel Survey. Clin Ther 37:1466–1476.e1. https://doi.org/10.1016/j.clinthera.2015.04.013

    Article  PubMed  Google Scholar 

  43. Wildes TM, Dua P, Fowler SA, Miller JP, Carpenter CR, Avidan MS, Stark S (2015) Systematic review of falls in older adults with cancer. J Geriatr Oncol 6:70–83. https://doi.org/10.1016/j.jgo.2014.10.003

    Article  PubMed  Google Scholar 

  44. Berggren M, Stenvall M, Englund U, Olofsson B, Gustafson Y (2016) Co-morbidities, complications and causes of death among people with femoral neck fracture-a three-year follow-up study. BMC Geriatr 16:120. https://doi.org/10.1186/s12877-016-0291-5

    Article  PubMed  PubMed Central  Google Scholar 

  45. Naito T, Mitsunaga S, Miura S, Tatematsu N, Inano T, Mouri T, Tsuji T, Higashiguchi T, Inui A, Okayama T, Yamaguchi T, Morikawa A, Mori N, Takahashi T, Strasser F, Omae K, Mori K, Takayama K (2019) Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non-small-cell lung cancer. J Cachexia Sarcopenia Muscle 10:73–83. https://doi.org/10.1002/jcsm.12351

    Article  PubMed  Google Scholar 

  46. Mouri T, Naito T, Morikawa A, Tatematsu N, Miura S, Okayama T, Omae K, Takayama K (2018) Promotion of behavioral change and the impact on quality of life in elderly patients with advanced cancer: a physical activity of the multimodal nutrition and exercise treatment for advanced cancer program. Asia Pac J Oncol Nurs 5:383–390. https://doi.org/10.4103/apjon.apjon_21_18

    Article  PubMed  PubMed Central  Google Scholar 

  47. Miura S, Naito T, Mitsunaga S, Omae K, Mori K, Inano T, Yamaguchi T, Tatematsu N, Okayama T, Morikawa A, Mouri T, Tanaka H, Kimura M, Imai H, Mizukami T, Imoto A, Kondoh C, Shiotsu S, Okuyama H, Ueno M, Takahashi T, Tsuji T, Aragane H, Inui A, Higashiguchi T, Takayama K (2019) A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small-cell lung or pancreatic cancer: the NEXTAC-TWO study protocol. BMC Cancer 19:528–528. https://doi.org/10.1186/s12885-019-5762-6

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

We would like to thank Ms. Asami Oba, a certified medical accountant at Shizuoka Cancer Center, for her instructions regarding medical costs.

Funding

The 35th grant-in-aid supported this work from the Japanese Foundation for the Multidisciplinary Treatment of Cancer in 2014 and the 47th Foundation for Promotion of Cancer Research for the Cancer Research General Task B.

Author information

Authors and Affiliations

  1. Division of Rehabilitation Medicine, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan

    Taro Okayama, Yusuke Yonenaga, Midori Kitagawa, Noriko Mitsuhashi, Takeshi Ishi & Hiroshi Fuseya

  2. Division of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan

    Tateaki Naito, Nobuaki Mamesaya, Takahisa Kawamura, Haruki Kobayashi, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami & Toshiaki Takahashi

  3. Department of Physical Medicine and Rehabilitation, Shizuoka General Hospital, 4-27-1 Kita Ando Aoi-ku, Shizuoka City, 420-8527, Japan

    Takuya Ohashi

  4. Division of Nutrition, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan

    Takashi Aoyama

  5. Clinical Research Center, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan

    Akifumi Notsu & Keita Mori

  6. Department of Rehabilitation Medicine, Juntendo Shizuoka Hospital, Juntendo University School of Medicine, 1129 Nagaoka, Izunokuni-shi, Shizuoka, 410-2295, Japan

    Akira Tanuma

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  1. Taro Okayama
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Contributions

TO and TN wrote the manuscript and prepared the figures and tables. TN was the chief investigator of the trial. KM and AN were responsible for the data analyses as biostatisticians. TO, TN, HF, and AT developed the trial design. TO, YY, TO, MK, NM, and TI collected the physical function data. TA collected the nutritional data. NM, TK, HK, SO, KW, AO, HK, HM, and TT recruited the participants and collected data. All the authors reviewed the manuscript and agreed to submit to the journal.

Corresponding author

Correspondence to Tateaki Naito.

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Conflict of interest

Mr. Okayama, Mr. Yonenaga, Mr. Ohashi, Ms. Kitagawa, Ms. Mitsuhashi, Mr. Ishi, Dr. Fuseya, Mr. Aoyama, Mr. Notsu, Mr. Mori, Dr. Mamesaya, Dr. Kawamura, Dr. Kobayashi, and Dr. Tanuma have nothing to disclose. Dr. Naito reports personal fees from Ono Pharmaceutical Co., Ltd., Pfizer Japan Inc., and Mochida Pharmaceutical Co., Ltd., which are unrelated to the submitted work. Dr. Omori reports personal fees from Ono Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., Taiho Pharmaceutical Co., Ltd., Daiichi-Sankyo Co., Ltd., and MSD K.K. Dr. Wakuda reports personal fees from Ono Pharmaceutical Co., Ltd., Taiho Pharmaceutical Co., Ltd., Boehringer Ingelheim Company., Eli Lilly K.K., and grants and personal fees from AstraZeneca K.K., Chugai Pharmaceutical Co., Ltd., Novartis Pharma K.K., and grants from AbbVie Company. Dr. Ono reports personal fees from Ono Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., Taiho Pharmaceutical Co., Ltd., AstraZeneca K.K., Eli Lilly K.K., MSD K.K., and Novartis Pharma K.K. Dr. Kenmotsu reports personal fees from Ono Pharmaceutical Co., Ltd., Eli Lilly K.K., Kyowa Hakko Kirin Co., Ltd., Bristol-Myers Squibb Company, MSD K.K., Novartis Pharma K.K., and grants from Daiichi-Sankyo Co., Ltd., and grants and personal fees from Chugai Pharmaceutical Co., Ltd., Boehringer Ingelheim Company, and AstraZeneca K.K., which are unrelated to the submitted work. Dr. Murakami reports personal fees from Bristol-Myers Squibb Company, Ono Pharmaceutical Co., Ltd., MSD K.K., and grants from AbbVie Company, Daiichi-Sankyo Co., Ltd., IQvia Company, and grants and personal fees from AstraZeneca K.K., Chugai Pharmaceutical Co., Ltd., Eli Lilly K.K., Taiho Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd., which are unrelated to the submitted work. Dr. Takahashi reports grants from Japan Agency for Medical Research and Development during the conduct of the study, and personal fees from Boehringer Ingelheim Company, Roche Diagnostics K.K., and grants and personal fees from AstraZeneca K.K., Chugai Pharmaceutical Co., LTD., Eli Lilly K.K., Ono Pharmaceutical Co., Ltd., MSD K.K., and Pfizer Japan Inc., which are unrelated to the submitted work.

Consent to participate

Informed consent was obtained from all participants included in the study.

Consent for publication

Informed consent was obtained for the data analysis and publication from all individual participants.

Code availability

Not applicable.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Name of the registry: UMIN (University Hospital Medical Information Network), date of registration: January 13, 2013, and date of enrolment of the first participant to the trial: January 23, 2013.

Supplementary Information

Supplementary Fig. 1.

Overall and disability-free survival curves in a subset excluding six patients who stopped the SWT based on the heart rate criteria. a Kaplan-Meier curve of overall survival. b Kaplan-Meier curve of disability-free survival. P-values were calculated using log-rank tests. Disabling events were defined as a reduction in the Barthel index from the baseline value by >10 points. For the patient whose disabling event was not confirmed, it was censored at the date of the last visit. (PPTX 97 kb)

Supplementary Fig. 2.

Overall and disability-free survival curves in the radical radiation therapy group. a Kaplan-Meier curve of overall survival. b Kaplan-Meier curve of disability-free survival. P-values were calculated using log-rank tests. Disabling events were defined as a decrease in the Barthel index from the baseline value by >10 points. (PPTX 79 kb)

Supplementary Fig. 3.

Overall and disability-free survival curves in the chemotherapy group. a Kaplan-Meier curve of overall survival. b Kaplan-Meier curve of disability-free survival. P-values were calculated using log-rank tests. Disabling events were defined as a reduction in the Barthel index from the baseline value by >10 points. (PPTX 87 kb)

Supplementary Fig. 4.

Cumulative length of hospital stay and inpatient medical costs in a subset excluding six patients who stopped the SWT based on the heart rate criteria. Curves show cumulative functions for hospital stay (panel a) and medical costs (panel b) in the mobile group (solid line) and the less mobile group (dotted line). (PPTX 60 kb)

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Okayama, T., Naito, T., Yonenaga, Y. et al. Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer. Support Care Cancer 29, 3961–3970 (2021). https://doi.org/10.1007/s00520-020-05953-5

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  • Issue Date:

  • DOI: https://doi.org/10.1007/s00520-020-05953-5

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