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Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis

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Abstract

Introduction

Aromatase inhibitors (AIs) are a well-established component of adjuvant therapy in postmenopausal women with hormone receptor (HR) + early stage breast cancer (BCa). We explored in an 18-month cohort study whether subjective oral health (OH), subjective periodontal health (PH), and oral health-related quality of life (OHRQoL) of postmenopausal BCa survivors on AIs differ from those of women without cancer diagnoses, and whether saliva flow, OH, PH, and OHRQoL are related.

Methods

Data were collected from 29 postmenopausal BCa survivors on AIs and 29 postmenopausal women without cancer diagnoses. Socio-demographic information, OH, PH, and OHRQoL were collected at baseline and 6, 12, and 18 months later. Unstimulated whole saliva volume per 15 min was determined by drooling.

Results

The two groups did not differ in background characteristics at baseline. Women on AIs had poorer OH (p = .043), PH (p = .04), and OHRQoL (p = .017), and lower saliva flow rate (p < .001) than control respondents. BCa survivors had the poorest PH at the 18-month visit. Xerostomia was correlated with OH at baseline and with OH and PH at 18 months. However, objective saliva flow rate was not correlated with OH or OHRQoL at this visit.

Conclusions

This study is the first to investigate the effects of AIs on patients’ subjective OH, subjective PH, and OHRQoL. The data suggest that women treated with AIs have worse OH, PH, and OHRQoL than women without cancer diagnoses. Interprofessional care is recommended so that women on AIs receive optimal supportive oral care to assure long-term OH and positive OHRQoL.

Trial registration

ClinicalTrials.gov NCT01272570

https://clinicaltrials.gov/ct2/show/NCT01272570.

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Authors and Affiliations

  1. Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109-1078, USA

    L. Susan Taichman

  2. Department of Internal Medicine, Hematology and Oncology Division, University of Michigan, Ann Arbor, MI, USA

    Catherine H. Van Poznak

  3. Department of Periodontics and Oral Medicine, School of Dentistry & Department of Psychology, College of Literature, Science & Arts, University of Michigan, Ann Arbor, MI, USA

    Marita R. Inglehart

Authors
  1. L. Susan Taichman
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  2. Catherine H. Van Poznak
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  3. Marita R. Inglehart
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Correspondence to L. Susan Taichman.

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Conflict of interest

The study was supported by a pilot grant from the Michigan Institute for Clinical and Health Research UL1RR024986 (University of Michigan, Ann Arbor, MI) and the National Institute of Dental & Craniofacial Research (NIDCR) grants 1K23DEO21779 (Bethesda, Maryland). The authors declare that they have no conflicts of interest.

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Taichman, L.S., Van Poznak, C.H. & Inglehart, M.R. Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis. Support Care Cancer 24, 4815–4824 (2016). https://doi.org/10.1007/s00520-016-3336-6

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  • DOI: https://doi.org/10.1007/s00520-016-3336-6

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