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Transforming growth factor beta signaling functions during mammalian kidney development

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Abstract

Aberrant transforming growth factor beta (TGFβ) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGFβ signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGFβ signaling during kidney development and how dysregulation of TGFβ signaling contributes to the pathogenesis of kidney malformation.

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Funding

The work was supported by a Canadian Institute of Health Research (CIHR) grant to NDR.

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  1. Mihai G. Dumbrava and Jon L. Lacanlale contributed equally to this work.

Authors and Affiliations

  1. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 686 Bay Street, Toronto, M5G 0A4, Canada

    Mihai G. Dumbrava, Jon L. Lacanlale, Christopher J. Rowan & Norman D. Rosenblum

  2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Canada

    Jon L. Lacanlale & Norman D. Rosenblum

  3. Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada

    Norman D. Rosenblum

  4. Department of Paediatrics, University of Toronto, Toronto, M5S 1A8, Canada

    Norman D. Rosenblum

  5. Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada

    Norman D. Rosenblum

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Dumbrava, M.G., Lacanlale, J.L., Rowan, C.J. et al. Transforming growth factor beta signaling functions during mammalian kidney development. Pediatr Nephrol 36, 1663–1672 (2021). https://doi.org/10.1007/s00467-020-04739-5

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