Skip to main content

Advertisement

SpringerLink
Log in

Donor considerations in pediatric kidney transplantation

  • Review
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

This article reviews kidney transplant donor options for children with end-stage kidney disease (ESKD). Global access to kidney transplantation is variable. Well-established national policies, organizations for organ procurement and allocation, and donor management policies may account for higher deceased donor (DD transplants) in some countries. Living donor kidney transplantation (LD) predominates in countries where organ donation has limited national priority. In addition, social, cultural, religious and medical factors play a major role in both LD and DD kidney transplant donation. Most children with ESKD receive adult-sized kidneys. The transplanted kidney has a finite survival and the expectation is that children who require renal replacement therapy from early childhood will probably have 2 or 3 kidney transplants in their lifetime. LD transplant provides better long-term graft survival and is a better option for children. When a living related donor is incompatible with the intended recipient, paired kidney exchange with a compatible unrelated donor may be considered. When the choice is a DD kidney, the decision-making process in accepting a donor offer requires careful consideration of donor history, kidney donor profile index, HLA matching, cold ischemia time, and recipient’s time on the waiting list. Accepting or declining a DD offer in a timely manner can be challenging when there are undesirable facts in the donor’s history which need to be balanced against prolonging dialysis in a child. An ongoing global challenge is the significant gap between organ supply and demand, which has increased the need to improve organ preservation techniques and awareness for organ donation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Walker RC, Naicker D, Kara T, Palmer SC (2018) Children’s experiences and expectations of kidney transplantation: a qualitative interview study. Nephrology 24:647–653. https://doi.org/10.1111/nep.13405

    Article  Google Scholar 

  2. Dharnidharka VR, Fiorina P, Harmon WE (2014) Kidney transplantation in children. N Engl J Med 371(6):549–558. https://doi.org/10.1056/NEJMra1314376

    Article  CAS  PubMed  Google Scholar 

  3. Sayegh MH, Carpenter CB (2004) Transplantation 50 years later--progress, challenges, and promises. N Engl J Med 351(26):2761–2766. https://doi.org/10.1056/NEJMon043418

    Article  CAS  PubMed  Google Scholar 

  4. Murray JE, Tilney NL, Wilson RE (1976) Renal transplantation: a twenty-five year experience. Ann Surg 184(5):565–573

    Article  CAS  Google Scholar 

  5. Kari JA, Romagnoli J, Duffy P, Fernando ON, Rees L, Trompeter RS (1999) Renal transplantation in children under 5 years of age. Pediatr Nephrol 13(9):730–736. https://doi.org/10.1007/s004670050689

    Article  CAS  PubMed  Google Scholar 

  6. Van Arendonk KJ, Boyarsky BJ, Orandi BJ, James NT, Smith JM, Colombani PM, Segev DL (2014) National trends over 25 years in pediatric kidney transplant outcomes. Pediatrics. 33(4):594–601. https://doi.org/10.1542/peds.2013-2775

    Article  Google Scholar 

  7. Report of the North American Pediatric Renal Trials and Collaborative Studies (2014) https://web.emmes.com/study/ped/annlrpt/annualrpt2014.pdf

  8. Harambat J, van Stralen KJ, Schaefer F et al (2013) Disparities in policies, practices and rates of pediatric kidney transplantation in Europe. Am J Transplant 13(8):2066–2074. https://doi.org/10.1111/ajt.12288

    Article  CAS  PubMed  Google Scholar 

  9. Rizvi SA, Sultan S, Zafar MN et al (2013) Pediatric kidney transplantation in the developing world: challenges and solutions. Am J Transplant 13:2441–2449. https://doi.org/10.1111/ajt.12356

    Article  CAS  PubMed  Google Scholar 

  10. Ploos van Amstel S, Noordzij M, Warady BA, Cano F, Craig JC, Groothoff JW, Ishikura K, Neu A, Safouh H, Xu H, Jager KJ, Schaefer F (2018) Renal replacement therapy for children throughout the world: the need for a global registry. Pediatr Nephrol 33(5):863–871. https://doi.org/10.1007/s00467-017-3863-5

    Article  PubMed  Google Scholar 

  11. OPTN/SRTR Annual report 2018. https://www.srtr.org/reports-tools/srtroptn-annual-data-report/

  12. OPTN/SRTR. Annual report. 2012. https://srtr.transplant.hrsa.gov/annual_reports/2012/Default.aspx

  13. DuBose J, Salim A (2008) Aggressive donor management protocols. J Intensive Care Med 23(6):367–375. https://doi.org/10.1177/0885066608324208

    Article  PubMed  Google Scholar 

  14. Collin M, Karpelowsky J, Thomas G (2017) Pediatric transplantation: an international perspective. Semin Pediatr Surg 26(4):272–277. https://doi.org/10.1053/j.sempedsurg.2017.07.003

    Article  PubMed  Google Scholar 

  15. Rudge C, Matesanz R, Delmonico FL, Chapman J (2012) International practices of organ donation. Br J Anaesth 108(Suppl 1):i48–i55. https://doi.org/10.1093/bja/aer399

    Article  PubMed  Google Scholar 

  16. Milner J, Melcher ML, Lee B, Veale J, Ronin M, D’Alessandro T, Hil G, Fry PC, Shannon PW (2016) HLA matching trumps donor age: donor-recipient pairing characteristics that impact long-term success in living donor kidney transplantation in the era of paired kidney exchange. Transplant Direct 2(7):e85. https://doi.org/10.1097/TXD.0000000000000597

    Article  PubMed  PubMed Central  Google Scholar 

  17. Van Arendok KJ, Garonzik Wang JM, Deshpande NA, James NT, Smith JM, Montgomery RA, Colombani PM, Segev DL (2013) Practice patterns and outcomes in retransplantation among pediatric kidney transplant recipients. Transplantation 95(11):1360–1368. https://doi.org/10.1097/TP.0b013e31828c6d64

    Article  Google Scholar 

  18. Van Arendok KJ, Cow EK, James NT, Orandi BJ, Ellison TA, Smith JM, Colombani PM, Segev DL (2015) Choosing the order of deceased donor and living donor kidney transplantation. Transplantation 99(2):360–366. https://doi.org/10.1097/TP.0000000000000588

    Article  Google Scholar 

  19. Yaffer HC, Fiedmann P, Kayler LK (2017) Very small pediatric donor kidney transplantation in pediatric recipients. Pediatr Transplant 21(5):e12924. https://doi.org/10.1111/petr.12924

    Article  Google Scholar 

  20. Salvatierra O, Singh T, Shifrin R et al (1998) Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow. Transplantation 66(7):819–823

    Article  Google Scholar 

  21. Muramatsu M, Mizutani T, Hamasaki Y et al (2019) Transplantation of adult-size kidneys in small pediatric recipients: a single-center experience. Pediatr Transplant:e13401. https://doi.org/10.1111/petr.13401

  22. Goldsmith PJ, Asthana S, Fitzpatrick M, Finlay E, Attia MS, Menon KV, Pollard SG, Ridgway DM, Ahmad N (2010) Transplantation of adult-sized kidneys in low-weight pediatric recipients achieves short-term outcomes comparable to size-matched grafts. Pediatr Transplant 14(7):919–924. https://doi.org/10.1111/j.1399-3046.2010.01375.x

    Article  CAS  PubMed  Google Scholar 

  23. Fontana I, Bertocchi M, Centanaro M, Varotti G, Santori G, Mondello R, Tagliamacco A, Cupo P, Barabani C, Palombo D (2014) Abdominal compartment syndrome: An underrated complicatinon in pediatric kidney transplantation. Transplant Proc 46(7):2251–2253. https://doi.org/10.1016/j.transproceed.2014.07.045

    Article  CAS  PubMed  Google Scholar 

  24. Naesens M, Kambham N, Concepcion W, Salvatierra O, Sarwal M (2007) The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant 7(11):2504–2514. https://doi.org/10.1111/j.1600-6143.2007.01949.x

    Article  CAS  PubMed  Google Scholar 

  25. Jalanko H, Mattila I, Holmberg C (2016) Renal Transplantation in infants. Pediatr Nephrol 31(5):725–735. https://doi.org/10.1007/s00467-015-3144-0

    Article  PubMed  Google Scholar 

  26. Humar A, Arrazola L, Mauer M, Matas AJ, Najarian AS (2001) Kidney transplantation in young children: should there be a minimum age? Pediatr Nephrol 16:941–945. https://doi.org/10.1007/s004670100000

    Article  CAS  PubMed  Google Scholar 

  27. Pelletier SJ, Guidinger MK, Merion RM et al (2006) Recovery and utilization of deceased donor kidneys from small pediatric donors. Am J Transplant 6(7):1646–1652. https://doi.org/10.1111/j.1600-6143.2006.01353.x

    Article  CAS  PubMed  Google Scholar 

  28. Maluf DG, Carrico RJ, Rosendale JD, Perez RV, Feng S (2013) Optimizing recovery, utilization and transplantation outcomes for kidneys from small, ≤20 kg, pediatric donors. Am J Transplant 13(10):2703–2712. https://doi.org/10.1111/ajt.12410

    Article  CAS  PubMed  Google Scholar 

  29. Kayler LK, Magliocca J, Kim RD, Howard R, Schold JD (2009) Single kidney transplantation from young pediatric donors in the united states. Am J Transplant 9(12):2745–2751. https://doi.org/10.1111/j.1600-6143.2009.02809.x

    Article  CAS  PubMed  Google Scholar 

  30. Sharma A, Fisher RA, Cotterell AH, King AL, Maluf DG, Posner MP (2011) En bloc kidney transplantation from pediatric donors: comparable outcomes with living donor kidney transplantation. Transplantation 92(5):564–569. https://doi.org/10.1097/TP.0b013e3182279107

    Article  PubMed  Google Scholar 

  31. Winnicki E, Dharmar M, Tancredi D, Butani L (2016) Comparable survival of en bloc versus standard donor kidney transplants in children. J Pediatr 173:169–174. https://doi.org/10.1016/j.jpeds.2016.01.054

    Article  PubMed  Google Scholar 

  32. Keith DS, Vranic G, Barcia J, Norwood V, Nishio-Lucar A (2017) Longitudinal analysis of living donor kidney transplant rates in pediatric candidates in the united states. Pediatr Transplant 21(2). https://doi.org/10.1111/petr.12859

  33. Van Cauwenberghe K, Raes A, Pauwels L, Dehoorne J, Colenbie L, Dequidt C, Dossche L, Vande Walle J, Prytuła A (2018) The choice between deceased- vs living-donor renal transplantation in children: analysis of data from a Belgian tertiary center. Pediatr Transplant 22(2). https://doi.org/10.1111/petr.13140

  34. Bendorf A, Pussell BA, Kelly PJ, Kerridge IH (2013) Socioeconomic, demographic and policy comparisons of living and deceased kidney transplantation rates across 53 countries. Nephrology (Carlton) 18(9):633–640. https://doi.org/10.1111/nep.12101

    Article  Google Scholar 

  35. van Heurn E, de Vries EE (2009) Kidney transplantation and donation in children. Pediatr Surg Int 25(5):385–393. https://doi.org/10.1007/s00383-009-2350-x

    Article  PubMed  Google Scholar 

  36. Pruthi R, O’Brien C, Casula A, Braddon F, Lewis M, O’Brien C, Tse Y, Inward C, Sinha MD (2013) UK renal registry 15th annual report: chapter 4 demography of the UK paediatric renal replacement therapy population in 2011. Nephron. 123(Suppl 1):81–92. https://doi.org/10.1159/000353323

    Article  PubMed  Google Scholar 

  37. Nishimura N, Kasahara M, Ishikura K, Nakagawa S (2017) Current status of pediatric transplantation in Japan. J Intensive Care 5:48. https://doi.org/10.1186/s40560-017-0241-0

    Article  PubMed  PubMed Central  Google Scholar 

  38. Ishikawa N, Yagisawa T, Sakuma Y, Fujiwara T, Kimura T, Nukui A, Yashi M (2012) Kidney transplantation of living unrelated donor-recipient combinations. Transplant Proc 44(1):254–256. https://doi.org/10.1016/j.transproceed.2011.11.019

    Article  CAS  PubMed  Google Scholar 

  39. Massie AB, Leanza J, Fahmy LM, Chow EK, Desai NM, Luo X, King EA, Bowring MG, Segev DL (2016) A risk index for living donor kidney transplantation. Am J Transplant 16(7):2077–2084. https://doi.org/10.1111/ajt.13709

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Ashby VB, Leichtman AB, Rees MA, Song PX, Bray M, Wang W, Kalbfleisch JD (2017) A kidney graft survival calculator that accounts for mismatches in age, sex, HLA, and body size. Clin J Am Soc Nephrol 12(7):1148–1160. https://doi.org/10.2215/CJN.09330916

    Article  PubMed  PubMed Central  Google Scholar 

  41. Flechner SM, Thomas AG, Ronin M, Veale JL, Leeser DB, Kapur S, Peipert JD, Segev DL, Henderson ML, Shaffer AA, Cooper M, Hil G, Waterman AD (2018) The first 9 years of kidney paired donation through the national kidney registry: characteristics of donors and recipients compared with national live donor transplant registries. Am J Transplant 18(11):2730–2738. https://doi.org/10.1111/ajt.14744

    Article  PubMed  PubMed Central  Google Scholar 

  42. Bingaman AW, Wright FH, Kapturczak M, Shen L, Vick S, Murphey CL (2012) Single-center kidney paired donation: the Methodist San Antonio experience. Am J Transplant 12(8):2125–2132. https://doi.org/10.1111/j.1600-6143.2012.04070.x

    Article  CAS  PubMed  Google Scholar 

  43. Sypek MP, Alexander SI, Cantwell L, Ierino FL, Ferrari P, Walker AM, Kausman JY (2017) Optimizing outcomes in pediatric renal transplantation through the Australian Paired Kidney Exchange Program. Am J Transplant 17(2):534–541. https://doi.org/10.1111/ajt.14041

    Article  CAS  PubMed  Google Scholar 

  44. Melcher ML, Leeser DB, Gritsch HA et al (2012) Chain transplantation: initial experience of a large multicenter program. Am J Transplant 12(9):2429–2436. https://doi.org/10.1111/j.1600-6143.2012.04156.x

    Article  CAS  PubMed  Google Scholar 

  45. Kute VB, Patel HV, Shah PR et al (2017) Impact of single centre kidney paired donation transplantation to increase donor pool in India: a cohort study. Transpl Int 7:679–688. https://doi.org/10.1111/tri.12956

    Article  Google Scholar 

  46. Delmonico FL, Harmon WE (2002) The use of a minor as a live kidney donor. Am J Transplant 2(4):333–336

    Article  Google Scholar 

  47. Joseph JW, Thistlethwaite JR, Josephson MA, Ross LF (2008) An empirical investigation of physicians’ attitudes toward intrasibling kidney donation by minor twins. Transplantation 85(9):1235–1239. https://doi.org/10.1097/01.tp.0000312675.51853.52

    Article  PubMed  Google Scholar 

  48. Krishnan N, Buchanan PM, Dzebisashvili N, Xiao H, Schnitzler MA, Brennan DC (2008) Monozygotic transplantation: concerns and opportunities. Am J Transplant 8(11):2343–2351. https://doi.org/10.1111/j.1600-6143.2008.02378.x

    Article  CAS  PubMed  Google Scholar 

  49. Ross LF, Thistlethwaite JR (2008) Committee on Bioethics. Minors as living solid-organ donors. Pediatrics 122(2):454–461. https://doi.org/10.1542/peds.2008-1525

    Article  PubMed  Google Scholar 

  50. Rao PS, Ojo A (2009) The alphabet soup of kidney transplantation: SCD, DCD, ECD -fundamentals for the practicing nephrologist. Clin J Am Soc Nephrol 4(11):1827–1831. https://doi.org/10.2215/CJN.02270409

    Article  PubMed  Google Scholar 

  51. Chaudhuri A, Gallo A, Grimm P (2015) Pediatric deceased donor renal transplantation: an approach to decision making II. Acceptability of a deceased donor kidney for a child, a snap decision at 3 AM. Pediatr Transplant 19(7):785–791. https://doi.org/10.1111/petr.12582

    Article  PubMed  Google Scholar 

  52. Thuong M, Ruiz A, Evrard P, Kuiper M, Boffa C, Akhtar MZ, Neuberger J, Ploeg R (2016) New classification of donation after circulatory death donors definitions and terminology. Transpl Int 29(7):749–759. https://doi.org/10.1111/tri.12776

    Article  PubMed  Google Scholar 

  53. Chen G, Wang C, Ko DS, Qiu J, Yuan X, Han M, Wang C, He X, Chen L (2017) Comparison of outcomes of kidney transplantation from donation after brain death, donation after circulatory death, and donation after brain death followed by circulatory death donors. Clin Transpl 31(11):e13110. https://doi.org/10.1111/ctr.13110

    Article  Google Scholar 

  54. MacConmara M, El Mokdad A, Gattineni J, Hwang CS (2019) Donation after cardiac death kidneys are suitable for pediatric recipients. Pediatr Transplant 6:e13540. https://doi.org/10.1111/petr.13540

    Article  Google Scholar 

  55. Pereira LDNG, Nogueira PCK (2019) Non-standard criteria donors in pediatric kidney transplantation. Pediatr Transplant 23(5):e13452. https://doi.org/10.1111/petr.13452

    Article  PubMed  Google Scholar 

  56. Marlais M, Pankhurst L, Hudson A, Sharif K, Marks SD (2017) UK National Registry Study of kidney donation after circulatory death for pediatric recipients. Transplantation. 101(6):1177–1181. https://doi.org/10.1097/TP.0000000000001264

    Article  PubMed  Google Scholar 

  57. Van Arendonk KJ, James NT, Locke JE, Montgomery RA, Colombani PM, Segev DL (2011) Late graft loss among pediatric recipients of DCD kidneys. Clin J Am Soc Nephrol 6(11):2705–2711. https://doi.org/10.2215/CJN.03760411

    Article  PubMed  PubMed Central  Google Scholar 

  58. Courtney AE, Maxwell AP (2009) The challenge of doing what is right in renal transplantation: balancing equity and utility. Nephron Clin Pract 111(1):c62-c67. https://doi.org/10.1159/000180121

  59. Rao PS, Schaubel DE, Guidinger MK, Andreoni KA, Wolfe RA, Merion RM, Port FK, Sung RS (2009) A comprehensive risk quantification score for deceased donor kidneys: The kidney donor risk index. Transplantation 88(2):231–236. https://doi.org/10.1097/TP.0b013e3181ac620b

    Article  PubMed  Google Scholar 

  60. Nazarian SM, Peng AW, Duggirala B, Gupta M, Bittermann T, Amaral S, Levine MH (2018) The kidney allocation system does not appropriately stratify risk of pediatric donor kidneys: implications for pediatric recipients. Am J Transplant 18(3):574–579. https://doi.org/10.1111/ajt.14462

    Article  CAS  PubMed  Google Scholar 

  61. Parker WF, Ross LF, Richard Thistlethwaite J, Gallo AE (2018) Impact of the kidney allocation system on young pediatric recipients. Clin Transpl 32(4):e13223. https://doi.org/10.1111/ctr.13223

    Article  Google Scholar 

  62. Shelton BA, Sawinski D, Ray C, Reed RD, MacLennan PA, Blackburn J, Young CJ, Gray S, Yanik M, Massie A, Segev DL, Locke JE (2018) Decreasing deceased donor transplant rates among children (≤6 years) under the new kidney allocation system. Am J Transplant 18(7):1690–1698. https://doi.org/10.1111/ajt.14663

    Article  PubMed  Google Scholar 

  63. Seem DL, Lee I, Umscheid CA, Kuehnert MJ (2013) United States Public Health Service. PHS guideline for reducing human immunodeficiency virus, hepatitis B virus, and hepatitis C virus transmission through organ transplantation. Public Health Rep 128(4):247–343. https://doi.org/10.1111/ajt.12386

    Article  PubMed  PubMed Central  Google Scholar 

  64. Chaudhuri A, Gallo A, Grimm P (2015) Pediatric deceased donor renal transplantation: an approach to decision making I. Pediatric kidney allocation in the USA: the old and the new. Pediatr Transplant 19(7):776–784. https://doi.org/10.1111/petr.12569

    Article  PubMed  Google Scholar 

  65. Wu DA, Watson CJ, Bradley JA, Johnson RJ, Forsythe JL, Oniscu GC (2017) Global trends and challenges in deceased donor kidney allocation. Kidney Int 91(6):1287–1299. https://doi.org/10.1016/j.kint.2016.09.054

    Article  PubMed  Google Scholar 

  66. Huml AM, Albert JM, Thornton JD, Sehgal AR (2017) Outcomes of deceased donor kidney offers to patients at the top of the waiting list. Clin J Am Soc Nephrol 12(8):1311–1320. https://doi.org/10.2215/CJN.10130916

    Article  PubMed Central  Google Scholar 

  67. Mohan S, Chiles MC (2017) Achieving equity through reducing variability in accepting deceased donor kidney offers. Clin J Am Soc Nephrol 12(8):1212–1214. https://doi.org/10.2215/CJN.06220617

    Article  PubMed Central  Google Scholar 

  68. Knackstedt ED, Danziger-Isakov L (2017) Infections in pediatric solid-organ transplant recipients. Semin Pediatr Surg 26(4):199–205. https://doi.org/10.1053/j.sempedsurg.2017.07.001

    Article  PubMed  Google Scholar 

  69. Sharma TS, Michaels MG, Danziger-Isakov L, Herold BC (2018) Clinical vignettes: donor-derived infections. J Pediatric Infect Dis Soc 7(2):S67–S71. https://doi.org/10.1093/jpids/piy129

    Article  PubMed  PubMed Central  Google Scholar 

  70. Shingde R, Habachou LI, Calisa V, Craig JC, Tong A, Chen SC, Wong G (2018) Unexpected donor-derived infectious transmissions by kidney transplantation: a systematic review. Transpl Infect Dis 20(2):e12851. https://doi.org/10.1111/tid.12851

    Article  PubMed  Google Scholar 

  71. Kaul DR, Covington S, Taranto S, Green M, Lyon GM, Kusne S, Miller RA, Blumberg EA (2014) Solid organ transplant donors with central nervous system infection. Transplantation 98(6):666–670. https://doi.org/10.1097/TP.0000000000000117

    Article  PubMed  Google Scholar 

  72. Smalley HK, Anand N, Buczek D et al (2018) Assessment of risk for transplant-transmissible infectious encephalitis among deceased organ donors. Transpl Infect Dis 20(5):e12933. https://doi.org/10.1111/tid.12933

    Article  PubMed  Google Scholar 

  73. Camargo JF, Simkins J, Anjan S, Guerra G, Vianna R, Salama S, Albright C, Shipman E, Montoya J, Morris MI, Abbo LM (2019) Implementation of a strongyloides screening strategy in solid organ transplant donors and recipients. Clin Transpl 33(4):e13497. https://doi.org/10.1111/ctr.13497

    Article  Google Scholar 

  74. Shaji Mathew J, Menon VP, Menon VP et al (2019) Dengue virus transmission from live donor liver graft. Am J Transplant 19(6):1838–1846. https://doi.org/10.1111/ajt.15270

    Article  CAS  PubMed  Google Scholar 

  75. Loftus MJ, Yong MK, Wilson S, Peleg AY (2019) Fatal disseminated visceral varicella zoster virus infection in a renal transplant recipient. Transpl Infect Dis 12:e13062. https://doi.org/10.1111/tid.13062

    Article  Google Scholar 

  76. El-Sharif A, Ashour HM (2008) Community-acquired methicillin-resistant staphylococcus aureus (CA-MRSA) colonization and infection in intravenous and inhalational opiate drug abusers. Exp Biol Med 233(7):874–880. https://doi.org/10.3181/0711-RM-294

    Article  CAS  Google Scholar 

  77. Lavender TW, Mccarron B (2013) Acute infections in intravenous drug users. Clin Med 13(5):511. https://doi.org/10.7861/clinmedicine.13-5-511

    Article  Google Scholar 

  78. Marshall BD, Kerr T, Livingstone C, Li K, Montaner JS, Wood E (2008) High prevalence of HIV infection among homeless and street-involved aboriginal youth in a Canadian setting. Harm Reduct J 5:35. https://doi.org/10.1186/1477-7517-5-35

    Article  PubMed  PubMed Central  Google Scholar 

  79. Strong DM, Nelson K, Pierce M, Stramer SL (2005) Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid. Cell Tissue Bank 6(4):255–262. https://doi.org/10.1007/s10561-005-2834-4

    Article  CAS  PubMed  Google Scholar 

  80. Davison KL, Ushiro-Lumb L, Lawrance M, Trotter P, Powell JJ, Brailsford SR (2019) Infections and associated behaviors among deceased organ donors: informing the assessment of risk. Transpl Infect Dis 21(2):e13055. https://doi.org/10.1111/tid.13055

    Article  CAS  PubMed  Google Scholar 

  81. Theodoropoulos N, Nowicki MJ, Chinchilla-Reyes C, Dionne S, Jaramillo A, Mone T, Hasz R, Jendrisak MD, Ladner DP, Ison MG (2018) Deceased organ donor screening for human immunodeficiency virus, hepatitis B virus and hepatitis C virus: discordant serology and nucleic acid testing results. Transpl Infect Dis 20(1). https://doi.org/10.1111/tid.12821

  82. Bowring MG, Holscher CM, Zhou S et al (2018) Turn down for what? Patient outcomes associated with declining increased infectious risk kidneys. Am J Transplant 18:617–624. https://doi.org/10.1111/ajt.14577

    Article  PubMed  Google Scholar 

  83. Kizilbash SJ, Rheault MN, Wang Q, Vock DM, Chinnakotla S, Pruett T, Chavers BM (2019) Kidney transplant outcomes associated with the use of increased risk donors in children. Am J Transplant 19(6):1684–1692. https://doi.org/10.1111/ajt.15231

    Article  CAS  PubMed  Google Scholar 

  84. Debout A, Foucher Y, Trébern-Launay K et al (2015) Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal transplantation. Kidney Int 87(2):343–349. https://doi.org/10.1038/ki.2014.304

    Article  PubMed  Google Scholar 

  85. Moers C, Smits JM, Maathuis MH et al (2009) Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 360(1):7–19. https://doi.org/10.1056/NEJMoa0802289

    Article  CAS  PubMed  Google Scholar 

  86. Patel SK, Pankewycz OG, Nader ND, Zachariah M, Kohli R, Laftavi MR (2012) Prognostic utility of hypothermic machine perfusion in deceased donor renal transplantation. Transplant Proc 44(7):2207–2212. https://doi.org/10.1016/j.transproceed.2012.07.129

    Article  CAS  PubMed  Google Scholar 

  87. Ciancio G, Gaynor JJ, Sageshima J et al (2010) Favorable outcomes with machine perfusion and longer pump times in kidney transplantation: a single-center, observational study. Transplantation 90(8):882–890. https://doi.org/10.1097/TP.ObO13e3181f2c962

    Article  PubMed  Google Scholar 

  88. Trnka P, McTaggart SJ, Francis A (2018) The impact of donor/recipient age difference and HLA mismatch on graft outcome in pediatric kidney transplantation. Pediatr Transplant 22(7):e13265. https://doi.org/10.1111/petr.13265

    Article  CAS  PubMed  Google Scholar 

  89. Opelz G, Döhler B (2010) Pediatric kidney transplantation: analysis of donor age, HLA match, and posttransplant non-Hodgkin lymphoma: a collaborative transplant study report. Transplantation 90(3):292–297. https://doi.org/10.1097/TP.0b013e3181e46a22

    Article  PubMed  Google Scholar 

  90. Nguyen HD, Williams RL, Wong G, Lim WH (2013) The evolution of HLA-matching in kidney transplantation. Current issues and Future Directıon in Kidney. Transplantation. https://doi.org/10.5772/54747

Download references

Funding

This work was supported in part by the Health Resources and Services Administration contract 234-2005-37011C.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Nephrology, University of Miami Miller School of Medicine, Miami Transplant Institute, PO Box 016960 (M714), Miami, FL, 33101, USA

    Jayanthi Chandar & Marissa Defreitas

  2. Department of Surgery, Division of Transplantation, University of Miami Miller School of Medicine, Miami Transplant Institute, Miami, FL, USA

    Linda Chen, Gaetano Ciancio & George Burke III

Authors
  1. Jayanthi Chandar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Linda Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marissa Defreitas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gaetano Ciancio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. George Burke III
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jayanthi Chandar.

Ethics declarations

Disclaimer

The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chandar, J., Chen, L., Defreitas, M. et al. Donor considerations in pediatric kidney transplantation. Pediatr Nephrol 36, 245–257 (2021). https://doi.org/10.1007/s00467-019-04362-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-019-04362-z

Keywords

Search

Navigation