Abstract
Background
Most patients with congenital nephrotic syndrome (CNS) exhibit a failure to thrive. A previous study reported that five of 41 (12 %) infants with CNS had hypertrophic pyloric stenosis (HPS) requiring surgery. The reason for this is undetermined, and there are few reports regarding the relationship between these conditions or their clinical course.
Case diagnosis/treatment
We present the case of a 4-month-old girl with CNS. She did not show typical manifestations of HPS, but thickened mucosal and submucosal layers and hypertrophy of the pyloric muscle were detected by repeated ultrasound examinations prior to the diagnosis of HPS. Pyloroplasty was performed to improve her poor weight gain and led to ideal growth.
Conclusions
Our case indicates that obstruction of the gastric outlet may be strongly associated with poor weight gain in patients with CNS. We should suspect involvement with HPS even if typical symptoms are lacking, and an aggressive intervention may improve poor growth. Thickened edematous mucosal and submucosal layers at the pyloric antrum have the potential to cause the high frequency of HPS in CNS.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None of the authors have any conflicts of interest to declare.
Ethical approval
For this type of study, formal consent is not required
Informed consent
Informed consent for publication of this report was obtained from the patient’s parents.
Additional information
The answers to these questions can be found at http://dx.doi.org/10.1007/s00467-016-3532-0
Rights and permissions
About this article
Cite this article
Takahashi, T., Sato, Y., Yamazaki, T. et al. Vomiting in an infant with congenital nephrotic syndrome: Questions. Pediatr Nephrol 32, 1519–1520 (2017). https://doi.org/10.1007/s00467-016-3529-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-016-3529-8