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Urinary endothelin-1-like immunoreactivity excretion in Wilms’ tumor survivors

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Abstract

Background

We evaluated urinary endothelin (ET)-1-like Immunoreactivity (uET-1 L) excretion in Wilms tumor (WT) survivors and investigated its relationships with glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). Glomerular hemodynamics were also assessed by Gomez formulae.

Methods

Seventeen WT survivors underwent renal sequential scintigraphy for residual kidney function determination including ERPF and GFR. Forty-five healthy individuals were selected as the control group. uET-1 L was measured by radioimmunoassay from the 24-h urine collection.

Results

In WT survivors, uET-1 L excretion was significantly higher than in controls. Significant correlations were found between uET-1 L and ERPF and GFR. Cluster analysis, applied on uET-1 L, identified two different patient groups. Between them, GFR and ERPF were significantly different. No significant difference existed between the two clusters for age and sex, elapsed time from nephrectomy, treatment, or nephrectomy side. Applying Gomez formulae, significant difference was found for afferent and total renal resistance.

Conclusions

According to our results, uET-1 L seems to be a marker of glomerular injury in patients with renal mass loss revealing renal overload condition. The uET-1 L role in renal damage progression and hemodynamic glomerular worsening in nephrectomized patients should be proven by prospective long-term follow-up studies, even for potential ET-1 receptor antagonist therapeutic use.

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Authors and Affiliations

  1. Biophysics and Nuclear Medicine, Hautepierre University Hospital, Strasbourg, France

    Alessio Imperiale

  2. LINC, UMR 7237, UDS/CNRS, Strasbourg, France

    Alessio Imperiale

  3. Nuclear Medicine, Department of Clinical Pathophysiology, University of Florence, Florence, Italy

    Catia Olianti, Maria Silvia Tommasi & Giuseppe La Cava

  4. Oncology, Department of Pediatrics, University of Florence, Florence, Italy

    Gabriella Bernini & Angela Tamburini

Authors
  1. Alessio Imperiale
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  2. Catia Olianti
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  3. Gabriella Bernini
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  4. Angela Tamburini
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  5. Maria Silvia Tommasi
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  6. Giuseppe La Cava
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Correspondence to Giuseppe La Cava.

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Imperiale, A., Olianti, C., Bernini, G. et al. Urinary endothelin-1-like immunoreactivity excretion in Wilms’ tumor survivors. Pediatr Nephrol 27, 1351–1359 (2012). https://doi.org/10.1007/s00467-012-2145-5

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  • DOI: https://doi.org/10.1007/s00467-012-2145-5

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