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Precursor B-cell lymphoblastic leukemia as a cause of a bilateral nephromegaly

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Abstract

Nephromegaly and non-oliguric acute renal failure is an unusual manifestation of lymphoblastic infiltration of the kidneys. We report the clinical history of a female child where a precursor B-cell lymphoblastic proliferation was diagnosed at the age of 21 months by a surgical renal biopsy for an unexplained bilateral nephromegaly. Lymphoblastic infiltration should be suspected in any patient presenting with unexplained renal failure and enlarged kidneys. The importance of renal biopsy to identify the etiology of renal failure and nephromegaly is emphasized.

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References

  1. Brunning RD, Borovitz M, Matutes E, Head D, Flandrin G, Swedlov SH, Bennett JM (2001) Precursor B lymphoblastic leukaemia/lymphoblastic lymphoma (precursor B-cell acute lymphoblastic leukaemia). In: Jaffe ES, Harris NL, Stein H, Vardiman JV (eds): Pathology and genetics of tumors of haematopoietic and lymphoid tissues. WHO classification tumours of haematopoietic and lymphoid tissue. IARC Press, Lyon, p 111

  2. Murphy SB (1978) Childhood non-Hodgkin’s lymphoma. N Engl J Med 299:1446–1448

    CAS  PubMed  Google Scholar 

  3. Maitra A, McKenna R, Weinberg A, Schneider N, Kroft S (2001) Precursor B-cell lymphoblastic lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature. Am J Clin Pathol 115:868–875

    Google Scholar 

  4. Vujanic GM, Webb D, Kelsey A (1995) B-cell non-Hodgkin’s lymphoma presenting as a primary renal tumor in a child. Med Pediatr Oncol 25:423–426

    Google Scholar 

  5. Truong LD, Cara WN, Ngo T, Laucirica, Katz R, Ramsy I (2001) Renal lymphoma. The diagnostic and therapeutic roles of fine-needle aspiration. Am J Clin Pathol 115:18–31

    Google Scholar 

  6. Bunchman TE, Gale GB, O’Connor DM, Salinas-Madrigal L, Chu JY (1992) Renal biopsy diagnosis of acute lymphocytic leukemia. Clin Nephrol 38:142–144

    Google Scholar 

  7. Richmond J, Sherman RS, Diamond HD, Craver LF (1962) Renal lesions associated with malignant lymphomas. Am J Med 32:184–207

    Google Scholar 

  8. Han BK, Babcoock DS (1985) Sonographic measurements and appearance of normal kidneys in children. AJR 145:611–616

    Google Scholar 

  9. Ellman L, Davis J, Lichtenstein NS (1974) Uremia due to occult lymphomatous infiltration of the kidneys. Cancer 33:203–205

    Google Scholar 

  10. Kanfer A, Vandewalle A, Morel-Maroger L, Feintuch MJ, Sraer JD, Roland J (1976) Acute renal insufficiency due to lymphomatous infiltration of the kidneys. Cancer 38:2588–2592

    Google Scholar 

  11. Randolph VL, Hall W, Bramson W (1983) Renal failure due to lymphomatous infiltration of the kidneys. Cancer 52:1120–1121

    Google Scholar 

  12. Glicklich D, Sung MV, Frey M (1986) Renal failure due to lymphomatous infiltration of the kidneys. Cancer 58:748–753

    Google Scholar 

  13. Gore RM, Shkolnik A (1982) Abdominal manifestation of pediatric leukemias: sonographic assessment. Radiology 143:207–210

    Google Scholar 

  14. Hartman CJ, Goldman SM, Friedman AC, Fritzsche P (1982) Renal lymphoma: radiological pathologic correlation of 21 cases. Radiology 144:759–766

    Google Scholar 

  15. Malena S, Gianviti A, Orazi C, Fariello G (1990) Renal echography in the early diagnosis of malignant hemolymphopathy in children. Apropos of 4 cases. Radiol Med (Torino) 80:564–567

    Google Scholar 

  16. Han BK, Babcoock DS (1985) Sonographic measurements and appearance of normal kidneys in children. AJR 145:611–616

    Google Scholar 

  17. Obrador GT, Price B, O’Meara Y, Salant DJ (1997) Acute renal failure due to lymphomatous infiltration of the kidneys. J Am Soc Nephrol 8:1348–1354

    Google Scholar 

  18. Lin P, Jones D, Dorfman DM, Meideros LJ (2000) Precursor B-cell lymphoblastic lymphoma. A predominantly extranodal tumor with low propensity for leukemic involvement. Am J Surg Pathol 24:1480–1490

    Google Scholar 

  19. Kahwash SB, Qualman SJ (2002) Cutaneous lymphoblastic lymphoma in children: report of six cases with precursor B-cell lineage. Pediatr Dev Pathol 5:45–53

    Google Scholar 

  20. Ozdemirti M, Fanburg-Smith JC, Hartmann DP, Shad AT, Lage JM, Magrath IT, Azumi N, Harris NL, Crossman J, Jaffe ES (1998). Precursor B-lymphoblastic lymphoma presenting as a solitary bone tumor and mimicking Ewing’s sarcoma. Am J Surg Pathol 22:795–804

    Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Faculty of Medicine, 11 Ivan Geshov Boulevard, 1606 Sofia, Bulgaria

    Anelia Boueva

  2. Central Laboratory of Pathological Anatomy and Cytology, Edouard Herriot Hospital, Place d’Arsonval, 69437 Lyon cedex 03, France

    Raymonde Bouvier

Authors
  1. Anelia Boueva
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  2. Raymonde Bouvier
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Correspondence to Anelia Boueva.

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Boueva, A., Bouvier, R. Precursor B-cell lymphoblastic leukemia as a cause of a bilateral nephromegaly. Pediatr Nephrol 20, 679–682 (2005). https://doi.org/10.1007/s00467-004-1740-5

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  • DOI: https://doi.org/10.1007/s00467-004-1740-5

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