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Hyponatremic-hypertensive syndrome with extensive and reversible renal defects

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Abstract

Two young children with renal artery stenosis and severe hypertension who presented with the so-called hyponatremic-hypertensive syndrome (HHS), with marked urine and solute loss during the acute phase, are described. Both children also presented with severe high molecular proteinuria, glycosuria, and hypercalciuria, only the first symptom having prompt remission after normalization of blood pressure. In children with renal artery stenosis, HHS is associated with severe proteinuria due to hyperfiltration and more extensive tubular functional alterations. Hyponatremia and acute tubulopathy may mask the presenting clinical picture of renal artery stenosis.

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References

  1. Blanc F, Bensman A, Baudon JJ (1991) Renovascular hypertension: a rare cause of neonatal salt loss. Pediatr Nephrol 5:304–306

    CAS  PubMed  Google Scholar 

  2. Agarwal M, Lynn KL, Richards AM, Nicholls MG (1999) Hyponatremic-hypertensive syndrome with renal ischemia: an underrecognized disorder. Hypertension 33:1020–1024

    CAS  PubMed  Google Scholar 

  3. Tisler A, Pierratos A, Honey JD, Bull SB, Rosivall L, Logan AG (2002) High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension. Nephrol Dial Transplant 17:253–259

    Article  CAS  PubMed  Google Scholar 

  4. Yamakawa H, Suzuki H, Nakamura M, Ohno Y, Saruta T (1992) Disturbed calcium metabolism in offspring of hypertension parents. Hypertension 19:528–534

    CAS  PubMed  Google Scholar 

  5. Kamijo T, Gonzalez JM, Jost LJ, Barrios R, Suki WN (1996) Renal abnormality of calcium handling in spontaneously hypertensive rats. Kidney Int [Suppl] 55:S166–S168

    Google Scholar 

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Acknowledgements

This work was supported by a grant from the Italian Ministry of Health to the Gaslini Institute (Ricerca Corrente).

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Authors and Affiliations

  1. Nephrology Unit, G. Gaslini Children’s Hospital, Largo Gaslini 5, Genoa, Italy

    Antonella Trivelli, Gian Marco Ghiggeri, Alberto Canepa & Francesco Perfumo

  2. Radiology Unit, G. Gaslini Children’s Hospital, Largo Gaslini 5, Genoa, Italy

    Mauro Oddone

  3. Cardiosurgery Unit, G. Gaslini Children’s Hospital, Largo Gaslini 5, Genoa, Italy

    Gianlauro Bava

Authors
  1. Antonella Trivelli
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  2. Gian Marco Ghiggeri
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  3. Alberto Canepa
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  4. Mauro Oddone
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  5. Gianlauro Bava
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  6. Francesco Perfumo
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Corresponding author

Correspondence to Francesco Perfumo.

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Trivelli, A., Ghiggeri, G.M., Canepa, A. et al. Hyponatremic-hypertensive syndrome with extensive and reversible renal defects. Pediatr Nephrol 20, 102–104 (2005). https://doi.org/10.1007/s00467-004-1648-0

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  • DOI: https://doi.org/10.1007/s00467-004-1648-0

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