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Laser-induced thermotherapy for the treatment of liver metastasis

Correlation of gadolinium-DTPA-enhanced MRI with histomorphologic findings to determine criteria for follow-up monitoring

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Abstract

Purpose: To evaluate gadolinium (Gd)-diethylenetriamine-pentaacetic-acid (DTPA)-enhanced magnetic resonance imaging (MRI) for follow-up monitoring of laser-induced thermotherapy (LITT) and to determine a useful examination schedule.

Methods: LITT of the liver was performed in 55 rabbits using a neodymium: yttrium-aluminum-garnet (Nd:YAG) laser (4-W power output, 840-s exposure time). Gd-DTPA MRI and histologic examinations were performed at different times (0–168 days).

Results: Laser-induced lesions underwent regeneration and volume size reduction (69% after 168 days). The correlation coefficient (MR vs. macroscopic analysis) for the mean lesion diameter was r= 0.96. Histology of lesions comprised the four zones that correlated best with MRI findings. Coagulation necroses immediately after LITT was seen as an area of no enhancement on Gd-DTPA MRI. Circular enhancement was first seen 72–96 h after LITT, which was due to early mesenchymal proliferation.

Conclusions: Gd-DTPA MRI is a good monitoring procedure for LITT. MRI should be performed 24 and 96 h after LITT.

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Authors and Affiliations

  1. Department of General, Vascular, and Thoracic Surgery, University Hospital, Benjamin Franklin Freie Universität Berlin, Hindenburgdamm 30, 12200 Germany, Germany

    C. -T. Germer, C. M. Isbert, D. Albrecht, J. P. Ritz & H. -J. Buhr

  2. Department of Radiology, University Hospital, Benjamin Franklin Freie Universität Berlin, Hindenburgdamm 30, 12200 Germany, Germany

    A. Schilling & K. -J. Wolf

  3. Institute for Medical, Technical, Physics, and Lasermedicine, University Medical Center, Benjamin Franklin Freie Universität Berlin, Hindenburgdamm 30, 12200 Germany, Germany

    A. Roggan & G. Müller

Authors
  1. C. -T. Germer
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  2. C. M. Isbert
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  3. D. Albrecht
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  4. J. P. Ritz
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  5. A. Schilling
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  6. A. Roggan
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  7. K. -J. Wolf
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  8. G. Müller
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  9. H. -J. Buhr
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Additional information

Received: 23 May 1997/Accepted: 20 November 1997

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Germer, C.T., Isbert, C.M., Albrecht, D. et al. Laser-induced thermotherapy for the treatment of liver metastasis. Surg Endosc 12, 1317–1325 (1998). https://doi.org/10.1007/s004649900849

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  • DOI: https://doi.org/10.1007/s004649900849

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