Abstract
Background
Methods of groin hernia repair include laparoscopic techniques using tissue-penetrating mesh fixation or non-penetrating fixation. Concerns regarding hernia repair include postoperative chronic pain, sexual dysfunction, and recurrence. Earlier estimations of recurrence rates have largely been based on nationwide databases, where reoperation rates have been used as a surrogate measure for recurrence, which may underestimate the true recurrence rates. The aim of this study was to evaluate long-term recurrence in patients who had undergone transabdominal pre-peritoneal (TAPP) laparoscopic groin hernia repair using either fibrin sealant or tacks for mesh fixation.
Methods
This study used data from the Danish Hernia Database to create the following cohort: All patients operated laparoscopically for primary groin hernia with a TAPP procedure using fibrin sealant for mesh fixation. These patients were matched 1:2 with patients, where the mesh was fixated using tacks. A validated questionnaire was sent to all included patients to determine recurrence, which was defined as reoperation or clinical diagnosis of recurrence by a physician. Follow-up was from index operation to either reoperation date, date of clinical recurrence diagnosis, or response date.
Results
A total of 2273 persons (n = 2340 groins) were included, of which 1535 returned the questionnaire, resulting in a response rate of 66.2 % with a median follow-up time of 31 months (range 0–62). Among these, 114 (7.4 %) recurrences were found, of which 30 (5.8 %) were in the fibrin sealant group and 84 (8.3 %) in the tacks group (p = 0.084). The Cox regression analysis found no difference in recurrence with the use of tacks compared to fibrin sealant (hazard ratio 0.8) [95 % CI (0.5–1.2)].
Conclusion
We found no significant difference in long-term reoperation rates and clinical recurrences in patients undergoing TAPP repair with meshes fixated with fibrin sealant compared with tacks.
Similar content being viewed by others
References
Primatesta P, Goldacre MJ (1996) Inguinal hernia repair: incidence of elective and emergency surgery, readmission and mortality. Int J Epidemiol 25:835–839
Campanelli G, Pascual MH, Hoeferlin A et al (2012) Randomized, controlled, blinded trial of Tisseel/Tissucol for mesh fixation in patients undergoing Lichtenstein technique for primary inguinal hernia repair: results of the TIMELI trial. Ann Surg 255:650–657
Fortelny RH, Petter-Puchner AH, Glaser KS et al (2012) Use of fibrin sealant (Tisseel/Tissucol) in hernia repair: a systematic review. Surg Endosc 26:1803–1812
Matthews RD, Neumayer L (2008) Inguinal hernia in the 21st century: an evidence-based review. Curr Probl Surg 45:261–312
Topart P, Vandenbroucke F, Lozac’h P (2005) Tisseel versus tack staples as mesh fixation in totally extraperitoneal laparoscopic repair of groin hernias: a retrospective analysis. Surg Endosc 19:724–727
Lau H (2005) Fibrin sealant versus mechanical stapling for mesh fixation during endoscopic extraperitoneal inguinal hernioplasty. Ann Surg 242:670–675
Aasvang EK, Møhl B, Bay-Nielsen M et al (2006) Pain related sexual dysfunction after inguinal herniorrhaphy. Pain 122:258–263
Burcharth J, Andresen K, Pommergaard HC et al (2014) Direct inguinal hernia and anterior surgical approach are risk factors for female inguinal hernia recurrences. Langenbecks Arch Surg 399:71–76
Helvind NM, Andresen K, Rosenberg J (2013) Lower reoperation rates with the use of fibrin sealant versus tacks for mesh fixation. Surg Endosc 27:4184–4191
Brügger L, Bloesch M, Ipaktchi R et al (2012) Objective hypoesthesia and pain after transabdominal preperitoneal hernioplasty: a prospective, randomized study comparing tissue adhesive versus spiral tacks. Surg Endosc 26:1079–1085
Bittner R, Gmähle E, Gmähle B et al (2010) Lightweight mesh and noninvasive fixation: an effective concept for prevention of chronic pain with laparoscopic hernia repair (TAPP). Surg Endosc 24:2958–2964
Vakalopoulos KA, Daams F, Wu Z et al (2013) Tissue adhesives in gastrointestinal anastomosis: a systematic review. J Surg Res 180:290–300
Duarte AP, Coelho JF, Bordado JC et al (2012) Surgical adhesives: systematic review of the main types and development forecast. Prog Polym Sci 37:1031–1050
Lodi D, Iannitti T, Palmieri B (2012) Management of haemostasis in surgery: sealant and glue applications. Blood Coagul Fibrinolysis 23:465–472
Lee MGM, Jones D (2005) Applications of fibrin sealant in surgery. Surg Innov 12:203–213
Ryou M, Thompson CC (2006) Tissue adhesives: a review. Tech Gastrointest Endosc 8:33–37
ASGE Technology Committee, Bhat YM, Banerjee S et al (2013) Tissue adhesives: cyanoacrylate glue and fibrin sealant. Gastrointest Endosc 78:209–215
Bay-Nielsen M, Kehlet H, Strand L et al (2001) Quality assessment of 26,304 herniorrhaphies in Denmark: a prospective nationwide study. Lancet 358:1124–1128
Helgstrand F, Rosenberg J, Kehlet H et al (2012) Reoperation versus clinical recurrence rate after ventral hernia repair. Ann Surg 256:955–958
Andersen LP, Klein M, Gögenur I et al (2009) Long-term recurrence and complication rates after incisional hernia repair with the open onlay technique. BMC Surg 9:6
Katkhouda N, Mavor E, Friedlander MH et al (2001) Use of fibrin sealant for prosthetic mesh fixation in laparoscopic extraperitoneal inguinal hernia repair. Ann Surg 233:18–25
Sajid MS, Ladwa N, Kalra L et al (2012) A meta-analysis examining the use of tacker fixation versus no-fixation of mesh in laparoscopic inguinal hernia repair. Int J Surg 10:224–231
Bittner R, Montgomery MA, Arregui E et al (2015) Update of guidelines on laparoscopic (TAPP) and endoscopic (TEP) treatment of inguinal hernia (international endohernia society). Surg Endosc 29:289–321
Schäfer M, Vuilleumier H, Di Mare L et al (2010) Fibrin sealant for mesh fixation in endoscopic inguinal hernia repair: is there enough evidence for its routine use? Surg Laparosc Endosc Percutan Tech 20:205–212
Petter-Puchner AH, Walder N, Redl H et al (2008) Fibrin sealant (Tissucol) enhances tissue integration of condensed polytetrafluoroethylene meshes and reduces early adhesion formation in experimental intraabdominal peritoneal onlay mesh repair. J Surg Res 150:190–195
Burcharth J, Andresen K, Pommergaard HC et al (2014) Recurrence patterns of direct and indirect hernias in a nationwide population in Denmark. Surgery 155:173–177
Kald A, Nilsson E, Anderberg B et al (1998) Reoperation as surrogate endpoint in hernia surgery: a three-year follow-up of 1565 herniorrhaphies. Eur J Surg 164:45–50
Disclosures
Mr. Fenger, Drs. Helvind, Burcharth, and Pommergaard have no conflicts of interest or financial ties to report. Dr. Rosenberg has received financial support from Baxter International Inc.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fenger, A.Q., Helvind, N.M., Pommergaard, HC. et al. Fibrin sealant for mesh fixation in laparoscopic groin hernia repair does not increase long-term recurrence. Surg Endosc 30, 986–992 (2016). https://doi.org/10.1007/s00464-015-4280-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00464-015-4280-0