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Redefining early gastric cancer

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Abstract

Background

The problem is that current definitions of early gastric cancer allow the inclusion of regional lymph node metastases. The increasing use of endoscopic submucosal dissection to treat early gastric cancer is a concern because regional lymph nodes are not addressed. The aim of the study was thus to critically evaluate current evidence with regard to tumour-specific factors associated with lymph node metastases in “early gastric cancer” to develop a more precise definition and improve clinical management.

Methods

A systematic and comprehensive search of major reference databases (MEDLINE, EMBASE, PubMed and the Cochrane Library) was undertaken using a combination of text words “early gastric cancer”, “lymph node metastasis”, “factors”, “endoscopy”, “surgery”, “lymphadenectomy” “mucosa”, “submucosa”, “lymphovascular invasion”, “differentiated”, “undifferentiated” and “ulcer”. All available publications that described tumour-related factors associated with lymph node metastases in early gastric cancer were included.

Results

The initial search yielded 1494 studies, of which 42 studies were included in the final analysis. Over time, the definition of early gastric cancer has broadened and the indications for endoscopic treatment have widened. The mean frequency of lymph node metastases increased on the basis of depth of infiltration (mucosa 6 % vs. submucosa 28 %), presence of lymphovascular invasion (absence 9 % vs. presence 53 %), tumour differentiation (differentiated 13 % vs. undifferentiated 34 %) and macroscopic type (elevated 13 % vs. flat 26 %) and tumour diameter (≤2 cm 8 % vs. >2 cm 25 %).

Conclusion

There is a need to re-examine the diagnosis and staging of early gastric cancer to ensure that patients with one or more identifiable risk factor for lymph node metastases are not denied appropriate chemotherapy and surgical resection.

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Acknowledgments

We thank Mr. Sanjay Talole, (Biostatistician, Tata Memorial Centre, Mumbai) for help with statistics.

Disclosures

S. G. Barreto and John A. Windsor have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Gastrointestinal Oncology, and Bariatric Surgery, Medanta Institute of Digestive and Hepatobiliary Sciences, Medanta, The Medicity, Gurgaon, India

    Savio G. Barreto

  2. HBP/Upper GI Unit, Department of General Surgery, Auckland City Hospital, Auckland, New Zealand

    John A. Windsor

  3. Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

    John A. Windsor

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Barreto, S.G., Windsor, J.A. Redefining early gastric cancer. Surg Endosc 30, 24–37 (2016). https://doi.org/10.1007/s00464-015-4184-z

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