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Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy

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Abstract

Background

This study was designed to test cyclin D1 as a prognostic marker in patients with soft tissue sarcomas (STS), and to evaluate the usefulness of laparoscopy for determining cyclin D1 overexpression.

Methods

The records of 62 patients with STS were collected: 28 with retroperitoneal STS (RSTS) and 34 with extremity STS (ESTS). A total of 51 patients underwent surgical resection, whereas 11 did not undergo surgery because of advanced tumor stage. Preoperative–intraoperative laparoscopic staging was performed for patients judged to be resectable at preoperative imaging.

Results:

Cyclin D1 was overexpressed in 30 (58.8%) of 51 resected patients and in 10 (90.9%) of 11 nonresected patients. Laparoscopy avoided unnecessary laparotomy in 9 (32.1%) of 28 RSTS patients.

Conclusions:

High tumor grade, positive surgical margins, local recurrence, distant metastases, and cyclin D1 overexpression were related to poor survival. Multivariate analysis demonstrated cyclin D1 to be the only independent factor. Laparoscopy was shown to be useful for avoiding useless laparotomies.

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References

  1. F Agresta P Simone ParticleDe I Michelet N Bedin (2003) ArticleTitleRetroperitoneal leiomyosarcoma mimicking acute appendicitis: laparoscopic management JSLS 7 177–179 Occurrence Handle12856853

    PubMed  Google Scholar 

  2. J Bartkova J Lukas M Strauss J Bartek (1995) ArticleTitleCyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis Oncogene 10 775–778 Occurrence Handle7862456

    PubMed  Google Scholar 

  3. MD Berardo CN Powers PE Wakely SuffixJr MO Almeida WJ Frable (1997) ArticleTitleFine-needle aspiration cytopathology of malignant fibrous histiocytoma Cancer 81 228–237 Occurrence Handle10.1002/(SICI)1097-0142(19970825)81:4<228::AID-CNCR5>3.0.CO;2-L Occurrence Handle9292738

    Article  PubMed  Google Scholar 

  4. MF Brennan ES Casper LB Harrison MH Shiu J Gaynor SI Hajdu (1991) ArticleTitleThe role of multimodality therapy in soft-tissue sarcoma Ann Surg 214 328–336 Occurrence Handle1929613

    PubMed  Google Scholar 

  5. J Buyske (2000) ArticleTitleRole of videoscopic-assisted techniques in staging malignant disease Surg Clin North Am 80 495–503 Occurrence Handle10.1016/S0039-6109(05)70198-5 Occurrence Handle10836004

    Article  PubMed  Google Scholar 

  6. E Croce S Olmi (2002) ArticleTitleLaparoscopia ed oncologia: collana monografica della Società Italiana di Chirurgia 17 81–87

    Google Scholar 

  7. P Dey MK Mallik SK Gupta RK Vasishta (2004) ArticleTitleRole of fine-needle aspiration cytology in the diagnosis of soft tissue tumors and tumor-like lesions Cytopathology 15 32–37 Occurrence Handle10.1046/j.0956-5507.2003.00102.x Occurrence Handle14748789

    Article  PubMed  Google Scholar 

  8. FR Eilber J Eckardt (1997) ArticleTitleSurgical management of soft tissue sarcomas Semin Oncol 24 526–533 Occurrence Handle9344318

    PubMed  Google Scholar 

  9. U Giger M Schafer L Krahenbuhl (2002) ArticleTitleTechnique and value of staging laparoscopy Dig Surg 19 473–478 Occurrence Handle10.1159/000067599 Occurrence Handle12499739

    Article  PubMed  Google Scholar 

  10. I Helmereich-Becker KH Meyer zyum Buschenfelde AW Lohse (1998) ArticleTitleSafety and feasibility of a new minimally invasive diagnostic technique Endoscopy 30 756–762 Occurrence Handle9932754

    PubMed  Google Scholar 

  11. MJ Heslin C Cordon-Cardo JJ Lewis JM Woodruff MF Brennan (1998) ArticleTitleKi-67 detected by Mib-1 predict distant metastases and tumor mortality in primary high grade extremity soft tissue sarcoma Cancer 83 490–497 Occurrence Handle10.1002/(SICI)1097-0142(19980801)83:3<490::AID-CNCR18>3.0.CO;2-R Occurrence Handle9690542

    Article  PubMed  Google Scholar 

  12. TJ Hieken TK Das Gupta (1996) ArticleTitleMutant p53 expression: a marker of diminished survival in well-differentiated soft tissue sarcoma Clin Cancer Res 2 1391–1395 Occurrence Handle9816312

    PubMed  Google Scholar 

  13. A Hoos JJ Lewis MF Brennan (2000) ArticleTitleSoft tissue sarcoma: prognostic factors and multimodal treatment Chirurg 71 787–794 Occurrence Handle10.1007/s001040051137 Occurrence Handle10986600

    Article  PubMed  Google Scholar 

  14. C Kettelhack U Tunn PM Schlag (1998) ArticleTitleStrategy for multimodal therapy of soft tissue sarcomas of the trunk and extremities Chirurg 69 393–401 Occurrence Handle10.1007/s001040050429 Occurrence Handle9612621

    Article  PubMed  Google Scholar 

  15. SH Kim NH Cho G Tallini M Dudas JJ Lewis C Cordon-Cardo (2001) ArticleTitlePrognostic role of Cyclin D1 in retroperitoneal sarcomas Cancer 91 428–434 Occurrence Handle10.1002/1097-0142(20010115)91:2<428::AID-CNCR1018>3.0.CO;2-# Occurrence Handle11180091

    Article  PubMed  Google Scholar 

  16. SH Kim JJ Lewis MF Brennan JM Woodruff M Dudas C Cordon-Cardo (1998) ArticleTitleOxerexpression of cyclin D1 is associated with poor prognosis in extremity soft-tissue sarcomas Clin Cancer Res 4 2377–2382 Occurrence Handle9796968

    PubMed  Google Scholar 

  17. K Kremer W Platzer HW Schreiber (1997) Minimal-invasive chirurgie: video-laparoskopische und video-thorakoskopische chirurgie Georg Thieme Verlag Stuttgart–New York

    Google Scholar 

  18. PF Lebowitz J Zujewski (2003) ArticleTitleHormonal therapy of breast cancer Curr Probl Cancer 27 297–331

    Google Scholar 

  19. EA Levine T Holzmayer S Bacus E Mechetner R Mera C Bollinger IB Roninson TK Das Gupta (1997) ArticleTitleEvaluation of newer prognostic markers for adult soft tissue sarcomas J Clin Oncol 15 3249–3257 Occurrence Handle9336362

    PubMed  Google Scholar 

  20. JJ Lewis D Leung JM Woodruff MF Brennan (1998) ArticleTitleRetroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution Ann Surg 228 355–365 Occurrence Handle10.1097/00000658-199809000-00008 Occurrence Handle9742918

    Article  PubMed  Google Scholar 

  21. M Lise CR Rossi S Alessio M Foletto (1995) ArticleTitleMultimodality treatment of extra visceral soft tissue sarcomas M0: state of the art and trends Eur J Surg Oncol 21 125–135 Occurrence Handle10.1016/S0748-7983(95)90039-X Occurrence Handle7720882

    Article  PubMed  Google Scholar 

  22. GB Mann JJ Lewis MF Brennan (1999) ArticleTitleAdult soft tissue sarcoma Aust N Z J Surg 69 336–343 Occurrence Handle10.1046/j.1440-1622.1999.01998.x Occurrence Handle10353547

    Article  PubMed  Google Scholar 

  23. CA Marijnen B Glimelius (2002) ArticleTitleThe role of radiotherapy in rectal cancer Eur J Cancer 38 943–952 Occurrence Handle10.1016/S0959-8049(02)00047-3 Occurrence Handle11978519

    Article  PubMed  Google Scholar 

  24. M Nishino K Hayakawa M Minami A Yamamoto H Ueda K Takasu (2003) ArticleTitlePrimary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues Radiographics 23 45–57 Occurrence Handle12533639

    PubMed  Google Scholar 

  25. BL Pratt FL Greene (2000) ArticleTitleRole of laparoscopy in staging malignant disease Surg Clin North Am 80 1111–1126 Occurrence Handle10.1016/S0039-6109(05)70216-4 Occurrence Handle10987027

    Article  PubMed  Google Scholar 

  26. I Ray-Coquard D Ranchere-Vince P Thiesse H Ghesquieres P Biron MP Sunyach M Rivoire L Lancry P Meeus C Sebban JY Blay (2003) ArticleTitleEvaluation of core needle biopsy as a substitute to open biopsy in the diagnosis of soft-tissue masses Eur J Cancer 39 2021–2025 Occurrence Handle10.1016/S0959-8049(03)00430-1 Occurrence Handle12957456

    Article  PubMed  Google Scholar 

  27. C Sandhu J Slingerland (2000) ArticleTitleDeregulation of the cell cycle in cancer Cancel Detect Prev 24 107–118

    Google Scholar 

  28. CJ Sherr (1996) ArticleTitleCancer cell cycles Science 274 1672–1677 Occurrence Handle10.1126/science.274.5293.1672 Occurrence Handle8939849

    Article  PubMed  Google Scholar 

  29. I Sheyn AE Noffsinger S Heffelfinger B Davis MA Miller CM Fenoglio-Preiser (1997) ArticleTitleAmplification and expression of the cyclin D1 gene in anal and esophageal squamous cell carcinomas Hum Pathol 28 270–276 Occurrence Handle10.1016/S0046-8177(97)90123-4 Occurrence Handle9042789

    Article  PubMed  Google Scholar 

  30. P Schrenk W Wayand (1995) ArticleTitleValue of diagnostic laparoscopy in abdominal malignancies Int Surg 80 353–355 Occurrence Handle8740682

    PubMed  Google Scholar 

  31. InstitutionalAuthorNameSociety of American Gastrointestinal Endoscopic Surgeons (1993) ArticleTitleGuidelines for diagnostic laparoscopy Surg Endosc 7 367

    Google Scholar 

  32. TD Theodoridis JN Bontis (2003) ArticleTitleLaparoscopy and oncology: where do we stand today? Ann N Y Aced Sci 997 282–291 Occurrence Handle10.1196/annals.1290.032

    Article  Google Scholar 

  33. P Wurl A Meye H Schmidt C Lautenschlager H Kalthoff FW Rath H Taubert (1998) ArticleTitleHigh prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities Oncogene 16 1183–1185 Occurrence Handle10.1038/sj.onc.1201646 Occurrence Handle9528860

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of General and Emergency Surgery, “Federico II” University Medical School, Building 12, Via S. Pansini 5, 80131, Naples, Italy

    M. Musella, S. Lombardi, C. De Martino & R. Jovino

  2. National Cancer Institute “G. Pascale”, Naples, Italy

    F. Fazioli

  3. Department of Orthopaedics and Traumatology, Federico II” University Medical School, Building 12, Via S. Pansini 5, 80131, Naples, Italy

    C. I. Servodio, V. Iacono & F. Cigala

Authors
  1. M. Musella
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  2. F. Fazioli
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  3. S. Lombardi
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  4. C. I. Servodio
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  5. C. De Martino
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  6. V. Iacono
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  7. F. Cigala
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  8. R. Jovino
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Correspondence to M. Musella.

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Musella, M., Fazioli, F., Lombardi, S. et al. Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy. Surg Endosc 19, 1120–1124 (2005). https://doi.org/10.1007/s00464-004-2094-6

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  • DOI: https://doi.org/10.1007/s00464-004-2094-6

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