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Modulation of B cell responses by Toll-like receptors

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Abstract

B lymphocytes are well known because of their key role in mediating humoral immune responses. Upon encounter with antigen and on cognate interaction with T cells, they differentiate into antibody-secreting plasma cells, which are critical for protection against a variety of pathogens. In addition to their antibody-production function, B cells are efficient antigen-presenting cells and express a variety of pathogen recognition receptors (PRRs). Engagement of these PRRs with their respective ligands results in cytokine and chemokine secretion and the upregulation of co-stimulatory molecules. These events constitute innate immune responses. Toll-like receptor (TLR) activation provides a third signal for B cell activation and is essential for optimal antigen-specific antibody responses. In some situations, TLR activation in B cells can result in autoimmunity. The purpose of this review is to provide some insights into the way that TLRs influence innate and adaptive B cell responses.

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Authors and Affiliations

  1. Vaccine & Infectious Disease Organization/International Vaccine Center, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada, S7N 5E3

    Jayaum Booth, Heather Wilson, Steve Jimbo & George Mutwiri

  2. Yale School of Medicine, Yale University, New Haven, USA

    Jayaum Booth

  3. School of Public Health, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    George Mutwiri

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  1. Jayaum Booth
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  2. Heather Wilson
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  4. George Mutwiri
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Correspondence to George Mutwiri.

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Research in the authors’ laboratory is funded by the Natural Sciences and Engineering Foundation, by Merial, and by the Alberta Agricultural Research Institute. This manuscript is published with the permission of the director of VIDO as journal series number 584.

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Booth, J., Wilson, H., Jimbo, S. et al. Modulation of B cell responses by Toll-like receptors. Cell Tissue Res 343, 131–140 (2011). https://doi.org/10.1007/s00441-010-1031-3

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