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Identification of cellular isoform of oviduct-specific glycoprotein: role in oviduct tissue remodeling?

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Abstract

The oviduct is known to secrete mucins (MUC1 and MUC9) under the influence of ovarian steroids. The secreted form of MUC1 binds gametes in the oviduct, whereas the cellular form seen in breast cancers has been implicated in cell adhesion and morphogenesis. The secreted MUC9 or oviduct-specific glycoprotein (OGP), in addition to being a mucin, belongs to family 18 glycosylhydrolases and is known to bind gametes and embryos in the oviduct. Studies in our laboratory have identified non-muscle myosin IIA (involved in cell shape, polarity, and morphogenesis) as the protein partner to OGP in gametes. In view of the crucial role of the cortical cytoskeleton in the selective internalization of tight junctions (TJs) /adherent junctions (AJs) or apical junctional complex (AJC) in simple epithelial cells during tissue remodeling, the present study has been undertaken to evaluate the existence of a cellular form of OGP in oviductal tissue, which itself undergoes cyclic tissue remodeling. In silico analysis of the deduced amino-acid sequence of OGP has revealed the presence of several conserved motifs; these imply that OGP is a component of multi-protein complexes such as TJs. Corroborative immunoelectron-microscopic analysis in peri-ovulatory oviduct epithelia in the bonnet monkey has revealed the presence of OGP at the TJ. Co-localization studies of OGP and cadherin demonstrate that, whereas OGP is localized at the tonofilaments of the TJs, cadherin is localized at the intercellular space of the AJ. The possible role of OGP in oviductal tissue remodeling is discussed in light of the present findings and those reported in the literature.

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Acknowledgements

We thank Dr. C.P. Puri, Director, for his encouragement during the course of this work. We are also grateful for the keen interest and encouragement of Dr. Vijaya Raghavan, Head of the Biochemistry Department, and of Dr. Geeta Vanage, Head of Electron Microscopy Department. Thanks are also due to Dr. D.D. Manjramkar, Animal House In-Charge, NIRRH for providing the oviduct samples from bonnet monkeys. Dr. Deepak Modi is acknowledged for his insights and suggestions.

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Authors and Affiliations

  1. National Institute for Research in Reproductive Health, Indian Council for Medical Research, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India

    Kaushiki M. Kadam, Serena J. D’Souza & Usha Natraj

Authors
  1. Kaushiki M. Kadam
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  2. Serena J. D’Souza
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  3. Usha Natraj
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Corresponding author

Correspondence to Usha Natraj.

Additional information

This study was supported by funds from the Indian Council for Medical Research and by senior research fellowships (to K. Kadam) from the Council for Scientific and Industrial Research.

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Kadam, K.M., D’Souza, S.J. & Natraj, U. Identification of cellular isoform of oviduct-specific glycoprotein: role in oviduct tissue remodeling?. Cell Tissue Res 330, 545–556 (2007). https://doi.org/10.1007/s00441-007-0489-0

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  • DOI: https://doi.org/10.1007/s00441-007-0489-0

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