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Selection, resistance risk assessment, and reversion toward susceptibility of pyriproxyfen in Musca domestica L.

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Abstract

Pyriproxyfen, a juvenile hormone mimic, is an effective larvicide against many pests of veterinary and public health importance. Pyriproxyfen is a biorational insecticide having many environmentally friendly attributes that make it compatible with integrated pest management programs. This experiment was performed for the assessment of resistance evolution and reversion toward susceptibility of Musca domestica to pyriproxyfen. Repeated selection at successive generations resulted in 5.09- and 130-fold increase in lethal concentration 50 (LC50) compared to field and susceptible strain, respectively. A significant decline after 22 generations without selection suggesting resistance to pyriproxyfen was unstable in M. domestica. Realized heritability (h 2) of resistance to pyriproxyfen was 0.035 in pyriproxyfen-selected strain of M. domestica. The projected rate of resistance development indicated that, if slope = 1.28 and h 2 = 0.035, then 46–21 generations are required for 10-fold increase in LC50 at 50–90 % selection intensity. These findings suggest that a risk for resistance development to pyriproxyfen occurred in M. domestica under continuous selection pressure. Pyriproxyfen susceptibility reversed when its application is ceased for a specified duration.

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Acknowledgments

The authors are highly thankful to Rachel Lehrer, strategist at Continuum Innovation, 1220 Washington St. West Newton, MA 02465, for critical review of manuscript to improve English language.

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Authors and Affiliations

  1. Department of Entomology, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Multan, Pakistan

    Rizwan Mustafa Shah, Naeem Abbas & Sarfraz Ali Shad

  2. Department of Entomology, University of Georgia, 463D Bio Sciences Building, Athens, GA, 30602-2603, USA

    Ashfaq Ahmad Sial

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  1. Rizwan Mustafa Shah
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  2. Naeem Abbas
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  4. Ashfaq Ahmad Sial
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Correspondence to Rizwan Mustafa Shah or Sarfraz Ali Shad.

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Shah, R.M., Abbas, N., Shad, S.A. et al. Selection, resistance risk assessment, and reversion toward susceptibility of pyriproxyfen in Musca domestica L.. Parasitol Res 114, 487–494 (2015). https://doi.org/10.1007/s00436-014-4206-0

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