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The survival analysis and feasibility study of Pars Plana Vitrectomy (PPV) in the treatment of retinoblastoma

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Abstract

Purpose

To analyze the safety and efficacy of Pars Plana Vitrectomy (PPV) as a treatment for retinoblastoma patients and to evaluate the feasibility.

Methods and patients

We collected 342 eyes who had PPV after systemic chemotherapy in our retrospective study, then analyze the 5-year overall survival and 5-year event-free survival rate, recurrence rate, and metastasis rate. The above data were used to evaluate the feasibility of PPV in the treatment of retinoblastoma.

Results

The mean value of follow-up time was 62.9 months from PPV. Of all 342 eyes, 18% eyes underwent enucleation of the eyeball. Excluding Non-PPV related deaths eyes, the 5-year overall survival rates and event-free survival were 95% and 80%; the tumor recurrence rate and metastasis rate were approximately 26% and 1.2%, respectively; the mortality was 3.9%. And the incidence of high-risk pathological factors of enucleated eyes after PPV was 32%.

Conclusion

Our results suggest that Pars Plana Vitrectomy as a new approach to preserve the eyeball of RB children is feasible, especially for those patients who cannot be completely controlled by systemic chemotherapy or the tumors with vitreous seeds. Although the outcomes in our study are very optimistic, we also recommend an experienced eye surgeon to perform the operation and strictly control the indications for PPV surgery. And enough systemic chemotherapy is very important before and after surgery.

Level of evidence

Treatment study (Retrospective comparative study), III.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

PPV:

Pars Plana Vitrectomy

RB:

Retinoblastoma

IVC:

Interventional chemotherapy of ophthalmic artery

VH:

Vitreous hemorrhage

IIRC:

International Intraocular Retinoblastoma Classification

AJCC):

American Joint Committee on Cancer

pTNM:

Pathological tumor-node-metastasis

H-PRFs:

High-risk pathological factors

DSM:

Disease specific mortality

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Healthy, Beijing, China

    Jianing Mou & Lei Yang

  2. National Center for Pediatric Center Surveillance, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Healthy, Beijing, China

    Junyang Zhao & Xin Ni

Authors
  1. Jianing Mou
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  2. Lei Yang
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  3. Junyang Zhao
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  4. Xin Ni
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JZ, XN and JM. JM wrote the main manuscript text and prepared all the figures and tables. All authors reviewed the manuscript.

Corresponding authors

Correspondence to Junyang Zhao or Xin Ni.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

As a retrospective study, our research did not involve human or animal trials, so the study did not require ethics approval.

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First author: Jianing Mou.

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Mou, J., Yang, L., Zhao, J. et al. The survival analysis and feasibility study of Pars Plana Vitrectomy (PPV) in the treatment of retinoblastoma. J Cancer Res Clin Oncol 149, 1313–1318 (2023). https://doi.org/10.1007/s00432-022-04466-4

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  • DOI: https://doi.org/10.1007/s00432-022-04466-4

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